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Analysis of the Аssociation of T2255C Polymorphism of the Vitamin K Epoxide Reductase Gene (VKORC1) With Ischemic Atherothrombotic Stroke in Patients With its Various Risk Factors
Authors: Yevhen I. Dubovyk, Alexander A. Potapov, Victoriia Yu. Garbuzova
Number of views: 394
T2255C polymorphism (rs2359612) of vitamin K epoxide reductase (VKORC1) gene was determined in 170 patients with ischemic atherothrombotic stroke (IAS) and in 124 persons of the control group. It was shown that the distribution of major allele homozygotes, heterozygotes and minor allele homozygotes in patients with IAS was 25,3%, 42,4%, 32,3% (in control – 36,3%, 42,7%, 21,0%; χ2 = 6,272; P = 0,043). According to logistic regression method the risk of IAS development in carriers of C/C genotype is 2.2 times higher than in the representatives of T/T genotype (OR = 2,214; P = 0.013). It has been proven the association with IAS for some studied risk factors. The risk of IAS in men with C/C genotype is 2.5 times higher than in the carriers of main allele T/T (OR = 2,522; P = 0.023). A statistically significant relationship between the level of blood pressure and the likelihood of IAS development in heterozygotes (T/C) was revealed (χ2 = 6,933; P = 0.008). It was found that homozygotes for the minor allele (C/C) with BMI <25 kg/m2 have the risk of stroke is almost 4 times higher than the carriers of T/T genotype (OR = 3,857; P = 0.034). Genotype C/C carriers without obesity 2.6 times more likely suffer from IAS, than the representatives of the T/T genotype (OR = 2,643; P = 0.011). Among those who do not smoke, the risk of IAS is higher among representatives of the C/C genotype (χ2 = 7,093; P = 0.029). Thus, there is the association of T2255C polymorphism of VKORC1 gene with ischemic atherothrombotic stroke in patients with its various risk factors.