COVID-19 and Endocrine System: A Cross-Sectional Study on 60 Patients with Endocrine Abnormality
Authors: Negin Hadisi, Hadi Abedi, Majid Shokoohi, Seval Tasdemir, Shahriyar Mamikhani, Shahla Meshgi, Arian Zolfagharzadeh, Leila Roshangar
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Objective: COVID-19 is an infectious disease that has become pandemic with a high mortality rate. This study aims to
provide new insight into the relations between SARS-CoV-2 and the Endocrine system.
Materials and Methods: In this cross-sectional study, we have hospitalized 60 patients with a positive SARA-CoV-2 PCR
test. The information of complete blood count and endocrine hormones was obtained when the patients were admitted to the
hospital or for a maximum of 4 days onset the hospitalization.
Results: Of 60 patients with COVID-19, forty-four (73.33%) had at least one abnormality mean item >×3. In total, 26 (43.33%),
21 (35%), 18 (30%), 13 (21.67%), 31 (51.67%), 12 (20%), 30 (50%), 25 (41.67%) patients having estradiol, follicle stimulating
hormone (FSH), luteinizing hormone (LH), prolactin, progesterone, testosterone, cortisol and thyroid stimulating hormone
(TSH) abnormal test results, respectively. There was no change in creatinine levels. FSH has shown drastic changes in both
sexes’ intensity (F: 769, P<0.0001). Although TSH had many abnormalities in women, analysis has shown no significant P
value (P=0.4558). Furthermore, prolactin and testosterone mean level in men and the estradiol mean level in women have
shown no significant P value (P=0.2077, P=0.1446, P=0.1351, respectively).
Conclusion: Results suggest that COVID-19 affects directly or non-directly glands and related hormones.