Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, anticancer, anticonvulsant and anti-HIV activity etc. The purpose of this review was to collate literature work reported by researchers on quinazoline for their various pharmacological activities. Quinazolinone derivatives are one of the most active classes of compounds possessing a wide spectrum of biological activity. Recently several scientists have been reported that introduction of various heterocyclic moieties at quinazolinone nucleus modulate the activity. Various derivatives of quinazolinone have been synthesized and evaluated for their biological activities. This review might be helpful in the development of these novel lead molecules to potential drug candidates for future prospect.
We report the synthesis of benzoxazoles using boric acid as catalyst in aqueous media. Synthesis of 2-substituted benzoxazoles derivatives from 2-amino phenol and a variety of aldehydes were developed under mild reaction conditions. The selection and use of water is emphasized as regards methods to minimize environmental impact. On completion of reaction the products were characterized by IR, NMR and Mass Spectra. These methods are more convenient and reactions can be carried out in higher yield.
Influence of iodine addition on elemental composition, structure and surface morphology on lead selenide thin films prepared by chemical bath deposition method was studied by methods of X-ray diffraction analysis and scanning electron microscopy with elemental energy-dispersive analysis. Content of iodine in thin films raised to 4.25 at.% with increasing concentration of ammonium iodide in bath solution. Influence of anneal on structure and crystallite size of lead selenide thin films was found.
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