EFICACIA Y SEGURIDAD DE LA TOXINA BOTULÍNICA EN LA HIPERHIDROSIS
Authors: Resano Sarmiento, N
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Hyperhidrosis is excessive sweating that affects patients’ quality of life, resulting in social and work impairment and emotional distress. There is an unusual entity called Frey Syndrome or atriotemporal nerve syndrome characterized by episodes of heat, erythema and hyperhidrosis of the face in the pre-atrial region, caused by taste stimuli. This disorder is a common complication of parotid gland surgeries and temporomandibular joint fracture, as a hypothesis of its presentation.
There are multiple therapeutic lines, botulinum toxin injection is the most studied and demonstrates a steady improvement in the Hyperhidrosis Disease Severity Scale scores and sweat production.
Given the important social impact of hyperhidrosis, I have decided to make a bibliographic review of one of the most studied and effective treatments, botulinum toxin. In this way I want to analyze the effects of it, the safety and evaluate how it affects the quality of life of these patients.
A systematic review of documents from scientific societies dedicated to health, as well as systematic reviews and scientific studies. Finally, I decided to include 2 meta-analysis, 4 systematic reviews, 1 prospective observational study and 3 cases or series of clinical cases published in scientific journals.
All the information, although the evidence is low because of the high risk of bias from the studies analyzed, it appears that subcutaneous botulinum toxin is effective and safe in primary hyperhidrosis and in Frey Syndrome. Evidence to recommend its use in symptoms of axillary hyperhidrosis is increased (moderate), however, more studies including higher-quality studies are required to establish stronger recommendations.