Therapeutic Alternatives to Antibiotic Administration in Veterinary Medicine
Authors: Chiurciu, C., Chiurciu, V., Danes, M., Stoica, O. G., Frunzareanu, B., Banciu, D., Lupu, E., Uluitu, C., Oprisiu, D., Stefan, P. C., Ionescu, I., Filip, V., Tudoran, C., Nicolae, I., Diaconu, L., Stanculescu, S., Radu, A., Chitonu, P.
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Starting from ONE HEALTH concept of integrated medicine in which human, animal and environmental health are approached together, this paper presents the attempts of ROMVAC Co. to reduce the risk of the occurrence and spread of antibiotic-resistant germs (ARGs) originating from the digestive tract of broiler chickens and mammary glands of dairy cows. The purpose is to demonstrate the efficacy of alternative veterinary medicines to antibiotic therapy in avian enteritis and dairy cow mastitis.
Enterococcus faecium NCIMB 11181 culture at a minimum concentration of 1x108 CFU / ml; Ross 308 broiler chickens (250,000 heads); automatic dosing system in water flow - Dosatrom. The product was administered during the first 3 days of life and the body weight evolution was monitored at 0, 7, 14, 21, 28 and 35 days. Oils with strong antibacterial and antiviral effects (oregano, thyme, pine etc.) were used by ROMVAC to produce three medicines: a) Greenvet mastirat - gel, curative, b) Ugeroclean - S, liquid soap and c) Ugeroclean - gel applied after milking. The products were administered locally to mammalian animals (cattle, sheep, goats) daily for 7 days. Udder edema, milk production, dermal reaction to the product (erythema, nodules, pustules, etc.) and clinical status of the animals were daily monitored.
Chickens that received probiotic had a weight gain of 68 grams / chicken (over 6 tons per 100,000 chickens) and a lower mortality rate of 0.78% (1794 chickens). E. coli and Salmonella germs have completely disappeared from the digestive tract.
Vegetable oil products improved clinical symptoms of mastitis, were well tolerated by animals, decreased the intensity of erythema, improved the clinical condition of animals, maintained milk production, very few cases requiring antibiotic treatment. The product is also an insect repellent. The in vitro antiviral activity of vegetable oils on CDV paramyxovirus has also been demonstrated. Replacement of antibiotic treatment in veterinary medicine with alternative therapies avoids the occurrence and transmission to the human consumer of ARGs via chicken and milk.