International Journal of New Chemistry

224-235

Authors: Maryam Negar Saberiyan Sani; Rahman Akbari

The perceived risk is assessed in order to conduct subjective evaluation of individual or community of probability of occurrence of accidents, crashes, and way of exposure to the related consequences. Although such estimation may not comply with what it occurs in real situation since this part is totally related to psychological aspect and at the same time it should be incorporated in planning for risk management. With respect to literacy, cultural, and gender levels and beliefs in communities, perception of the probable risk may be followed by some fluctuations. It has been tried in the present project to explore effect of factor of fear of disease on perceived possible risk among the people who live at neighborhood of MDF Manufacturing Companies. To analyze the rate of effect of fear of disease on the perceived possible risk at region and their relationship with demographic attributes including age, gender, education, having children, and employment in factory, the questionnaire with close-end questions of Likert spectrum type was administered. Data were analyzed by SPSS (v.16) and two-sample t-test and Pearson’s correlation coefficient and linear regression with (p

254-276

Authors: Mehdi Nabati; Vida Bodaghi-Namileh

The present research article relates to the discovery of the novel drugs based on Zonisamide to treatment of autism disease. In first step, the electronic properties, reactivity and stability of the said compound are discussed. To attain these properties, the said molecular structure is optimized using B3LYP/6-311++G(d,p) level of theory at room temperature. The frontier molecular orbitals (FMOs) energies are used to calculate the global reactivity indices. Based on these indices, Zonisamide is a high stable compound and has low reactivity. In the next step, the optimized molecular structure of Zonisamide is docked into the potassium voltage-gated channel subfamily D member 2 (Kv4.2) and ligand-receptor interactions are analyzed. After that, the novel molecular structures based on Zonisamide backbone are designed and optimized. Designing the novel drugs are done using changes the backbone of Zonisamide and various functional groups. The interactions of the optimized molecular structures with the said potassium channel are analyzed using docking study.Based on these studies, ten molecules showed better ligand-receptor binding than Zonisamide. Finally, the physicochemical properties of the title compounds are analyzed. The compounds P3TZ, H2P3TZ, M2P3TZ, H4P3TZ and M4P3TZ are our novel drugs to treatment of autism disease based on the molecular docking and physicochemical properties.

289-298

Authors: Mohammad Noormohammadi; Molood Barmala

The oil industry needs solid and reliable materials in almost all processes. By making nano-scale materials, lighter, more robust, and more robust equipment than today's products can be produced. Nanotechnology in the field of oil industry and its related industries, in addition to reducing the environmental hazards of this sector and the possibility of saving from harvesting of underground reserves, will provide the basis for the growth of the country's major industries. Oil and gas industry in Iran is a long time and enjoyed. From these enormous resources, it has created a special place for the country. The effort to achieve technology and improve the status of these industries is something that should be given special attention. For this reason, the oil, gas and petrochemical industries have not gone away far beyond the penetration of nanotechnology, and nanotechnology has also entered this area.