1685 – 1688
EFFECT OF VITAMIN C TREATMENT ON SERUM PROTEIN, ALBUMIN, BETAGLOBULIN PROFILES AND BODY WEIGHT OF Trypanosoma brucei- INFECTED Rattus norvegicus
Authors: EDOGA, Cyril Onyekachi, NJOKU, Oliver O., OKEKE, John Johnson and ANI, C. E.
Number of views: 619
The effect of vitamin C supplements on serum protein profile and body weight of Trypanosoma brucei-infected rats was investigated. The rats were inoculated with
trypanosomes intraperitoneally and samples were collected on fourth, eight, twelfth and sixteenth days of post infection (pi). Sixty (60) parasite free-albino rats were used, which were divided into four groups. Group A (control) was left uninfected with trypanosomes,
group B and C were infected with Trypanosomes and treated with 40mls and 60mls of ascorbic acid (Vitamin C), respectively. Trypanosoma brucei infection caused significant (p<0.01) decreases in serum total proteins, albumin, beta globulin and body weight levels in untreated rats. Consumption of Vitamin C, however, prevented these disease induced anomalies in the treated infected rats. Analyses of the sera using Bradford
method and cellulose acetate electrophoresis showed that Vitamin C infected the state of serum protein, albumin and gamma globulin in the trypanosome-infected treated rats. It was concluded that consumption of the Vitamin C ameliorated the pathological changes in serum protein and body weight of T. brucei – infected rats.