Potentiometric determination of Benzydamine hydrochloride using PVC membrane and coated wire sensors in pure form, pharmaceutical compounds and biological fluids.
Authors: Mohamed M. Khalil, *1 Yousry M. Issa,2 Mohamed A. Korany, 1
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The construction and electrochemical response characteristics of PVC membrane and coated wire sensors for the determination of Benzydamine hydrochloride (Benz) are described. PVC membrane sensors, include sensors 1, 2 and 3, and coated-wire sensors include sensors 4, 5 and 6. Sensors 1 and 4 based on benzydamine - phosphotungstate (Benz-PTA) as ion-pair, sensors 2 and 5 based on benzydamine - phosphomolybdate (Benz-PMA) as ion-pair and sensor 3 and 6 based on benzydamine - reineckate (Benz-RN) as ion-pair. Sensors 1, 2 and 3 (PVC membrane sensors) have a linear concentration range from 7.0×10−6 to 1.0×10−2, 1.0×10−5 to 1.0×10−2 and 1.0×10−5 to 1.0×10−2 mol L−1, with a Nernstian slope of 58.6±0.3, 59±0.4 and 58.7±0.2 mV/decade and a detection limit of 5.0×10−6, 7.2×10−6 and 1.0×10−5 mol L−1, respectively. Sensors 4, 5 and 6 (coated-wire sensors) have the same linear concentration range from 1.0×10−6 to 1.0×10−2 mol L−1, with the same detection limit of 1.0×10−6 mol L−1 and with a Nernstian slope of 58.9±0.1, 60.0±0.5 and 59.5±0.4 mV/decade, respectively. The response is independent of the pH of test solution within the range 3–8 for PVC membrane sensors and within 2-8 for coated-wire(CW) sensors. All sensors show fast response time which is 5, 3, 3, 8, 6 and 7 s for sensors 1, 2 , 3, 4, 5 and 6, respectively. The sensors showed good selectivity towards benzydamine with respect to large numbers of species. . The sensors have been applied to the determination of benzydamine in pure solution, pharmaceutical compounds and biological fluids.