Journal of Clinical and Experimental Medical Research

4

Authors: Markevych O. V.

This article is devoted to study the changes of the rat’s bone tissue of different age groups influenced by the radiation low doses. It is proved that application of «calcium - gluconate» provides significant decrease of osteoporosis especially at a young age, while the rogression of osteoporosis is slowed down in the old rats.

4

Authors: Popov S. V.

The aim of the investigation was to study maturity suspected dysplasia of the hip. 75 children (aged till 1 year) were examined by ultrasound diagnostic method. The slowed hip formation at 81.33 % of patients is revealed, the broken formation - at 2.67%. Normalization of ultrasound data takes place mainly during in the second half of the year.

4

Authors: Matyash V. I., Ralets N. V., Berezina L. V.

The article presents survey data on 142 patients with meningoencephalitis using fotopletyzmography. We prove that the violation of the autonomic nervous system is the pathogenesis chain meningoencephalitis affect the severity of the pathological process. Besides, it is also the objective method for assessing the severity and the criterion of dynamic observation of the patient.

5

Authors: Spivak J. S., Bondarenko V. O., Miroshnichenko A. V.

The article is devoted to study the semen haracteristics, levels of testosterone in the infertile men with autoimmune thyroiditis, and in the patients with pathospermia against chronic prostatitis before and after therapy with CARDONAT, vitamin E and tsefasel. It is shown that this treatment increases mobility and improves viability of spermatozoa. It is found that treatment reduced sperm agglutination; it coincides with a reduction of antibodies to tyreoperoxidase in the infertile men with autoimmune thyroiditis. It is proved that the intended therapy has not affected the functional state of the thyroid gland and the secretion of testosterone by the testes in the patients with euthyroid state and normal quantity of testosterone in the blood.

5

Authors: Zhornyak О. I.

The research results of antimicrobial agents’ effects on the adhesion of gram-positive and gram-negative microorganisms were described. The studies have shown that antiseptics (such as septefril, sebidin, adzhysept) inhibited adhesion of bacteria. The lowest index of adhesiveness observed in the presence of septefril.

5

Authors: Rudenko T. M.

The article proves the effectiveness of the ursodeoxycholic acid drug application for the non-alcoholic steatohepatitis treatment in the patients with hypertension and obesity. Application of the ursodeoxycholic acid drug accelerates normalization of clinical manifestations, normalization of biochemical parameters of liver function and lipid metabolism, reduces sonographic phenomenon of the fatty liver infiltration. The positive clinical effects and positive dynamics of biochemical and sonographic indicators confirm enhancement of metabolism in the liver cells in the majority of patients. These factors may recommend the ursodeoxycholic acid application for treatment and prevention.

5

Authors: Suhonos V. A.

This article presents comparative characteristics of structural and functional parameters of the trunk vessels and clinical laboratory indices in the patients with stage II hypertension with different body mass. It is determined, that hyperinsulinemia and systemic inflammatory response factors of C-reactive protein and interleukin-6 take part in vascular remodeling mechanisms and arterial hypertension progression in the patients with normal body mass and with the obesity.

5

Authors: Korytskyy G. I.

A high prevalence of endocrine diseases in children and adolescents with simultaneous tendency to reduce the incidence is revealed in Ternopil region by a comprehensive analysis of the dynamics of basic health indicators - prevalence, incidence, its structure in children up to 14 years and adolescents. These indicators show the need for a qualitative examination of children with active detection of diseases of the endocrine system of primary health service - family physicians, pediatricians.

6

Authors: Slisarenko O. V.

Reparative bones regeneration peculiarities under cellular dehydration were researched on aged laboratory male rats. The shin bone was fractured under cellular dehydration modeling. From the commencement of the experiment the percentage composition of regenerate cells changed. Increasing dehydration caused more changes. Further dehydration conditions resulted in isregenerative changes and tissue structure inhibition, which is evident due to the remains of the granulation tissue on the 15th day under the medium and high dehydration levels and the remains of the fibroreticular tissue – on the 24th day under the high dehydration level. The changes were not detected in the control set of animals. These changes were confirmed with the raster electron microscopy. One can also observe the reduction of the basic chemical elements, hardness disturbance, and general growth inhibition. The result of these changes is general inhibition of callus formation.

6

Authors: Kulikova M. V., Ascheulova T. V

The article is devoted to study carbohydrate metabolism characteristics and identify the I/D gene polymorphism of the angiotensin-converting enzyme in the patients with arterial hypertension. This arterial hypertension is accompanied with a type II diabetes mellitus. We examined 103 patients with arterial hypertension; they were randomized into two groups distinguishing either they preserve or not the type II diabetes mellitus. During the research we have figured out that the majority of patients from the both groups were the carriers of D-allele angiotensin-converting enzyme gene (the patients with DD and ID genotypes). The patients with arterial hypertension and unfavorable DD and ID genotypes had significant worsening of carbohydrate metabolism characteristics, such as insulin and HbA1c. It can be regarded as the proof of a bad prognosis about possible the type II diabetes mellitus development if the D-allele angiotensin-converting enzyme gene is carried. Existence of ID genotype caused body-weight and arterial pressure increasing. We have pointed out essential differences among systolic pressure, diastolic pressure, body-weight index and insulin in the patients from the 2nd group (the subgroup with a manifestation of ID genotype). These proved the complicated character of arterial hypertension course, which was accompanied with the type II diabetes mellitus.

8

Authors: Korepanov A. L.

Adaptive potential correlations of the adolescents with different physical development were figured due to the results of analyzed physio-metric, functional and energy-supply indexes. Early developers had lower adaptive potential comparing to the adolescents of the same age. The article provided information about the correlations between interchange of energy and aerobic potential, on the one hand, and the essential figures of physical development, on the other hand.

8

Authors: Vynnychenko L. B., Holovko T. M., Bezsmertna R.V.

The aim of the investigation was to study the peculiarities of the course and multifunctional condition of myocardium in patients with chronic cardiac insufficiency (CCI) on the background of ischemic heart disease (IHD) in combination with chronic obstructive pulmonary disease (COPD). 134 patients aged from 45 to 78 were supervised, with CCI of functional class (FC) II and III of ischemic origin. The main group consisted of patients with CCI of FC II and III with concomitant COPD of II and III stages (n=74). The control group was represented by patients with CCI of FC II and III without impaired external respiration function (ERF). We estimated the structural and functional parameters of cardiovascular system by echocardiography method, we also took into account life quality of the patients, dyspnea intensity degree by the developed scales, biochemical and clinical blood analysis, ERF investigation and saturation of blood by oxygen. The investigation results showed life quality deterioration in all investigated patients (according to Minnesota questionnaire) and in patients with combined pathology it was reasonably lower. The basic factors of cardiovascular risk which significantly differred the group of patients with CCI of ischemic origin in combination with COPD from the isolated one were tobacco smoking and Arterial hypertension. The study of concomitant COPD comparing to the patients with CCI without COPD pointed on the significant increase in the right atrium (RA), right ventricle (RV), mean diameter of pulmonary artery (MDPA) size. Besides, we noticed other features, such as arterial hypertension was more frequent, left ventricular hypertrophy (LVH), predicted unfavorable types of LV remodeling (concentric and eccentric), the number of people with “delayed” type of left ventricle diastolic dysfunction (LVDD) at the expense of increase in number of patients with intermediate “pseudonormal” LVDD disturbance. At the equal FC of CCI, the patients with concomitant COPD comparing to the patients with CCI without COPD, have more increased volume of haemoglobin and erythrocyte.Thus, with the signs of the right parts of the heart increase in patients with CCI on the background of IHD with preserved systolic function of the left ventricle. We can assume concomitant COPD and continue the investigation to specify the diagnosis.

9

Authors: Bereznyakov I. G., Makharynskа O. S., Doroshenko O. V

Issues to determine community-acquired pneumonia in the patients with type II diabetes mellitus are considered in the article. The clinical course is analyzed.