Black Sea Scientific Journal of Academic research

4-7

Authors: A.V. Aliyev

The lung cancer on number of again falling ill persons keeps first place in the world among men and the fourth place among women. (16, 24, 26, 27, 32) All forms of the central lung cancer, but much earlier endobronchial eventually leads to a bronchial stenosis. (29, 32) Diagnostic process of stenoses of large bronchi includes studying a roentgen-computer picture of bronchi, carrying out on this basis bronchoscopy with a capture of a pathological material for citomorphological investigation. (5, 18, 27, 31) It is a unique method of specification of the true reason of organic bronchial stenoses. Central lung cancer is the tumour affecting proximal, i.e. the central departments of a bronchial tree, including subsegmentary branches also. (3, 31, 32) In conformity with development of bronchoscopic technique last decades became accessible to survey not only segmentary bronchial tubes, but also their subsegmentary branches, i.e. bronchial tubes of the fourth order. Accordingly, distal border of the central cancer was displaced: it is a tumour affecting main, intermediate, the share, segmentary and subsegmentary bronchi. (3, 31) The tumour which source is little bronchus, at presence expressed peribronchial node, is considered as a peripheral cancer. (3, 31) In part, the tumour growing outside from a bronchial tube, refers to - peribronchial, growing inside - endobronchial. Hence at the central cancer the bronchial stenosis is caused endoluminal by the located tumoral growths at endobronchial to the form, or peribronchial squeezing at peribronchial to the form of growth of a tumour. (19, 23, 31) It is necessary to note that, central peribronchial cancer in difference from endobronchial is characterized by indirect attributes, which else up to biopsy allow well founded to suspect the tumoral nature of bronchial stenosis. (15, 32) But, the peribronchial stenosis is better displayed at CT. (11, 26, 29) In part, each of these forms can be shown as nodal or infiltrative growth. In case of endobronchial cancer nodal growth inside of a lumen of a bronchial tube refers to extraluminal, and mucous membrane infiltration and undermucous layer - intraluminal. As the extra form consider extreme expression infiltrative growth with endobronchial defeat of bronchial tree on the big extent. It’s frequent with transition to a trachea and the opposite side. Such kind of a tumour has received the name branched out. (3, 31) Many authors allocate also the mixed type of growth of a tumour. (27) In all cases of the mixed growth the tumour quickly is exposed sclerosing, involving in process not only share but also segmentary bronchi, (11, 27, 31) And at bronchoscopy are diagnosed symptoms infiltration of mucous membrane, on roentgenograms of thorax and CT comes to light peribronchial shadow of tumour. (18, 29)

14-18

Authors: B.K. Kochlamazashvili, L.N. Qoqiashvili, K.H. Jandieri

The aim of the research was to investigate ultramicroscopic peculiarities of heart at following levels of antigen loading using adult and old aged gnotobiot rats, conventional rats and rats, with experimental autoimmune cardiomyopathy. The results of investigations showed that the ultrastructural characteristics of heart greatly depend on microbiological status and age of experimental animals. The ultrastructure of heart mostly depends on the level of intensity of antigen loading in adult rats, than at old aged ones. In all experimental groups of old rats’ the sub cellular differences had the same directions. Although, must be mentioned that there was not registered a significant correlations difference between the level of heart damage and intensity of antigen loading. According from this age-related changes depend not only on microbiological status of organisms, but on genetically determined peculiarities of internal regulative processes takeing place during the ontogenesis. Consequently, the control of autoantibody production, stimulated by over crossed antigens is realized, probably, by another way, than the control of age-related increasing of autoantibody synthesis, existing in practice. Thus, the received results may be used to identify age-related changes, which give us the possibilities for the differentiation of ageing and pathological peculiarities. Key words: Gnotobiont – rats, autoimmune cardiomyopathy, heart, ultrastructure, ageing.l

26-28

Authors: T. Okropiridze

A complete cure of periodontitis is the central problem in the Dental practice and in Medicine – generally. The cure of periodontitis depends on many factors, for example on the virulence of microorganisms, a general position of the body and on the tactics of cure. During the cure of periodontal diseases with traditional methods, same time we used the complex methods of curing, particularly – after the plasmic therapy course we filled the channels with stimulating osteogenesis facilities. During clinical research 127 patients were involved in treatment, which were devided into 3 groups – depending on diagnosis and treatment course (traditional or complex). Before the cure as well as after treatment we performed X-ray diagnostic investigation. The use of plasmic stream causes the important stimulation of body immune system, has the strong bactericidal effect, anti-inflammatory and analergical actions. Mentioned method causes the widening of vessels – improving the feeding of tissues, activates the synthesis of vitamins and stimulates a regenerative processes. While the X-ray investigation was shown the results of curing with traditional and complex methods. By using traditional method of curing the period of treatment was shortened in 33% of patients, with complex treatment – 48%. The abovementioned data show the effectivness for the cure of periodontal chronic diseases. Due to this fact we strongly recommend its using in practical dentistry.

33-39

Authors: A.K. Mustafayev, A.B. Bahshaliyev, F.S. Ibrahimov

It was studies influence of some antiplatellent agents to blood lipid methabolism. After 3 mounth we came to the following conclusions: Fraxiparin has a positive to lipid metabolism, aspirin has a positive effect to lipid metabolism, fraxiparin enhanced lipoprotinlipase activity, and diabetus melitus decreased the efficeancy of aspirin and fraxiparin to lipid metabolism. Keywords: acute coronary syndrome, diabetes mellitus, lipid metabolisms, asetisalisic acid, fraxiparine

44-47

Authors: Galogre A., Tsagareli Z.

The study of mucosal gingival microcirculatory bed in conditions modeling the change of vascular wall permeability that promotes cell migration and plasmorrhagia.The experiments were made on 3 groups of chinchilla rabbits – body weight 1,7-2,5 kg; I – experimental gingivitis (10 animals); II – experimental hypercholesterolemia – the rabbits received aterogenic diet (0,3gr/kg of cholesterol) (10 animals). Two months after the aterogenic diet, gingivitis was modeled against the background of hypercholesterolemia (control for group II). IV series – conditionally named “normal” – 5 rabbits. The light-optic and electron microscopic studies have revealed significant changes in extracellular matrix and gingival mucous cells as in microcirculatory bed components in hypercholesterolemia.Hypercholesterolemia damages endotheliocytes, subendothelial zone, basal membrane and changes permeability. The contact of lymphocytes and plasmocytes with the vascular wall confirms the trigger role of the vascular factor in damaging of parodontal complex. Key Words: gingival microcirculation, hypercholesterolemia, gingivitis, experiment, rabbits