938-942
Synthesis, Characterization and Antimicrobial Screening of Novel Hydrazide Ligand & It’s Transition Metal Complexes
Authors: S.P. Bhale , A.R. Yadav , S.U. Tekale , R.B. Nawale , R.P. Marathe , P.S. Kendrekar and R.P. Pawar*
Number of views: 130
Different transition metal complexes were synthesized from novel 3-bromo-2-[1-(4-hydroxy-6-methyl2-oxo-2H-pyran-3-yl)ethylidene]hydrazide ligand (H2L) and characterized by spectral techniques. The
synthesized ligand was found to act mono as well as di deprotonated (OH, NH) manner and
stoichiometry of the ligand to metal ions was confirmed to be 1:1 in case of complex using metal
chloride salts, whereas 1:2 in case of metal(II) complexes using metal acetate(II) salt. Structures of
metal complexes were confirmed by IR, 1
H NMR, TGA, XRD, elemental analysis and UV technique
which revealed that Mn(II), Co(II), Ni(II), Cu(II) complexes were octahedral geometry and those of
Cu(II), Zn(II) showed square planner and tetrahedral geometry around metal ion respectively.
Furthermore H2L and its metal complexes were screened for antimicrobial activity which showed that
ligand enhanced its biological activity after coordination with metal ions. In particular, Cd(II) and
Mn(II) complexes exhibited excellent antifungal activity