International Journal of Current Research in Chemistry and Pharmaceutical Sciences

17

Authors: T. DHANABAL

A survey of literature indicates that an extensive work has been done on various picrate complexes. Realising the importance of the complexes, we undertook the synthesis and characterization of some of the organic picrate crystals. The complexes were characterized by spectral, structural, thermal, optical, dielectric, mechanical and antimicrobial studies. The following six organic picrate complexes were synthesized and characterized. The synthesized complexes were grown by slow evaporation solution growth method at room temperature and were characterized by elemental analysis, solubility study, powder X-ray diffraction, single crystal X-ray structure analysis and UV-visible, emission, Fourier transform infrared (FTIR), polarized Raman and nuclear magnetic resonance (NMR) spectra. Thermogravimetric analysis (TGA), differential thermal analysis (DTA), differential scanning calorimetry (DSC) and microhardness measurement, dielectric, nonlinear optical property (NLO) and antimicrobial activity studies were also carried out. Keywords: Picrate complexes, Spectral, Structural, Optical, Dielectric, Antimicrobial studies.

24-27

Authors: E. BAGYA RAJ1 AND S. DINESH KUMAR2

There are many nitrogen containing heterocyclic-picrate complexes to be synthesized and characterized. Among the organic picrate complexes synthesized so far, there are many other physical properties yet to be studied. The complete structural studies for all the picrate complexes synthesized so far are not available in the literature. Thermal analyses (TG-DTA and DSC) and spectral studies (UV-visible, Emission, Polarized Raman, FTIR and NMR) for many picrate complexes are not reported. Properties like dielectric, nonlinear optical, mechanical of a number of picrate complexes are not studied)benzamide, PBB, have been reported under microwave radiation. The product is obtained in good yield. Key Words: Microwave, PBA, PBN, PBB, Antibacterial activity.

37-44

Authors: S. SIVAKUMAR1,* AND A. MANIMEKALAI2

Two N-acyl-t(3)-isopropyl-r(2),c(6)-bis(p- chlorophenyl)piperidin-4-ones 1–2 and their parent piperidin-4- one 3 were synthesized and the high resolution 1H and 13C NMR spectra have been recorded and analyzed. The spectra reveal the presence of two rotameric forms (syn and anti) in solution for 1–2. 1H- 1H and 1H-13C COSY spectra have been recorded to assist the assignment of the signals for the syn and anti isomers of 1–2. Coupling constants predict an equilibrium mixture of boat conformation B1/B5 and alternate chair form CA for 1–2. The molecular structures of 1–2 were also determined using DFT calculations available in Dmol3 package and the results have been compared with the results derived from spectral studies. The effect of varying the substituents at nitrogen on the 1H and 13C chemical shifts has been analyzed in detail. Keywords: N-Substitutedpiperidin-4-ones; Spectral; Computational studies

56-64

Authors: R.NELSON1 AND V.SHANTHI 2

More than 25 million people in the United States suffer from liver and gallbladder diseases, according to the American liver Foundation. And, more they 43,000 die of a liver disease each year. The bilary system-consisting of the bile ducts and the gall-bladder, and the pancreas are all also closely associated with the functioning of the liver. Some liver, biliary, and Pancreatic diseases are congenital. Others can be prevented. In any case, whether these diseases are congenital injury, viral-induced, or alcohol- induced, they can be devastating to a person’s health and require professional care. Key words: liver and gallbladder diseases, American liver Foundation, Pancreatic diseases

75-92

Authors: DHANDAYUTHAPANI SIVANESAN1 AND VIMAL ANAND2

The antimicrobial properties of diethyl ether, benzene, alcohol, acetone, ethyl acetate, distilled water extracts of medicinal plant sample were investigated against seven infectious bacterial strains and six fungal strains. The medicinal plant sample employed for the present tests, which include, Achyranthes aspera. The medicinal plant sap was extracted using separating funnel apparatus; concentrated and then it was investigated for antibacterial and antifungal activity by disc diffusion technique. The inhibitory effect widely varied with the solvents diethyl ether, benzene, alcohol, acetone, ethyl acetate, distilled water plant extracts to the test organisms employed. Results showed that diethyl ether extract of Achyranthes aspera possess better antibacterial and antifungal activity. The benzene, ethyl acetate, and distilled water extracts of A. aspera showed moderate activity of both antifungal and antibacterial activity. The liver and kidney exhibit numerous morphological and functional alterations during diabetes. Since both diabetes and hyperlipidemia are considered to be major risk factors for the premature atherosclerosis and essentially all the cholesterol in atherosclerotic plaques is derived from that of circulatory cholesterol. The antihyperlipidemic and antiperoxidative effect of extract of A.aspera in particular could be considered as of possible therapeutic value.The bio-chemical analysis of compound was done by radial paper chromatography technique. In this, amino acid like Tryptophan, Tyrosine and Arginine were identified. Also lipids and vitamin were separated by paper chromatography. Key words: Achyranthes aspera, antibacterial and antifungal activity, diabetes and hyperlipidemia, antihyperlipidemic and antiperoxidative effect, radial paper chromatography,

105-111

Authors: *K. VANMATHI SELVI1 AND T. SIVAKUMAR2

Nanoparticles have shown exceptional electronic, catalytic, optical, magnetic and other physical and chemical properties that are quite different from the bulk one. Silver nanoparticles have proven useful in antibacterial clothing, burn ointments and as coating for medical devices because of their mutation resistant antimicrobial activity. To fulfill the growing need of environmental friendly nanoparticles, researchers are using microorganisms for the synthesis of various silver nanoparticles of F. oxysporum has been reported to possess potent anthelmintic, anticancer and antioxidant activity . Keywords: Silver Nanoparticles, anthelmintic, anticancer and antioxidant activity .