Prevalence of the hepatitis C virus among university employees in São Paulo, Southeastern Brazil: predictive factors and geoprocessing spatial analysis
Authors: Cássio Vieira de OLIVEIRA, Walnei Fernandes BARBOSA, Liciana Vaz de Arruda SILVEIRA, Juliana MENEZES, Flávia Souza MACHADO, Giovanni Faria SILVA
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Background – There are limited studies on the prevalence and risk factors associated with hepatitis C virus (HCV) infection.
Objective – Identify the prevalence and risk factors for HCV infection in university employees of the state of São Paulo, Brazil.
Method – Digital serological tests for anti-HCV have been performed in 3153 volunteers. For the application of digital testing was necessary to withdraw a drop of blood through a needlestick. The positive cases were performed for genotyping and RNA. Chisquare and Fisher’s exact test were used, with P-value <0.05 indicating statistical signi!cance. Univariate and multivariate logistic regression were also used.
Results – Prevalence of anti-HCV was 0.7%. The risk factors associated with HCV infection were: age >40 years, blood transfusion, injectable drugs, inhalable drugs (InDU), injectable Gluconergam®, glass syringes, tattoos, hemodialysis and sexual promiscuity. Age (P=0.01, OR 5.6, CI 1.4 to 22.8), InDU (P<0.0001, OR=96.8, CI 24.1 to 388.2), Gluconergam® (P=0.0009, OR=44.4, CI 4.7 to 412.7) and hemodialysis (P=0.0004, OR=90.1, CI 7.5 – 407.1) were independent predictors. Spatial analysis of the prevalence with socioeconomic indices, Gross Domestic Product and Human Development Index by the geoprocessing technique showed no positive correlation.
Conclusion – The prevalence of HCV infection was 0.7%. The independent risk factors for HCV infection were age, InDU, Gluconergan® and hemodialysis. There was no spatial correlation of HCV prevalence with local economic factors.
HEADINGS – Hepacivirus. Spatial analysis. Genotyping techniques.