Journal of Natural Remedis

99-113

Authors: Shriti Singh, Sangeeta Gehlot, N. K. Agrawal

Ayurveda and contemporary science comprehends human body as model to understand disease state from very different perspective hence their methodology to describe disease manifestation also seems very different as they observe same problem from different viewpoints. For more precision in healthcare system it is essential that best of both systems need to be integrated, In Ayurvedic texts, the description of concept of basic constitution/Prakriti in health and disease states is well described. The scripts are not clearly understandable and hence its importance has not been properly understood by contemporary biological researchers and thus not utilized. According to Ayurveda individual’s basic constitution (Prakriti) influences and directs one’s disease status, its treatment & lifestyle regimen. In genomics, individual’s basic constitution is decided by its genetic makeup. The current trend in Ayurveda-related biomolecular studies is establishment of high correlation between Prakriti and Genomics. This approach of Ayurgenomics would facilitate the development of alternative methods for cost effective screening of predisposed individuals in the population. This would result in development of an integrated approach to systems biology for disease and health state. For the establishment and success of this concept the prerequisite is integration of Ayurveda into mainstream contemporary biology to achieve global acceptability for the concepts and science of Ayurveda, and for this Ayurvedic concept based phenotypic (Prakriti) assessment needs to be made so that difference among individuals from large population based on their physical, physiological and psychological status can be observed and they can be categorized by their specific predominant Prakriti i.e. Vata, Pitta, Kapha. Information about individual predominant Prakriti can be further analyzed on certain genomic parameters related to gene expression, genetic, epigenetic and biochemical factors, which can be further utilized for Integration of Ayurveda with Genomics for systems biology approach in predictive and personalized medicine.

124-134

Authors: Mia Permawati, Effionora Anwar, Ade Arsianti, Anton Bahtiar

The use of traditional medicine in the treatment of disease has increased globally due to its safety and efficacy. Ageratum conyzoides (L.) L. and Oldenlandia corymbosa L. have been used traditionally as a topical preparation for joint disease in Indonesia. Hence, the study was planned to scientifically study the existing empirical data. A nanoemulgel of combined Ageratum conyzoides (L.) L. (ACE) and Oldenlandia corymbosa L. Extract (OCE) as a new drug focused on plant-based natural products with a good physical characteristic that inhibits inflammatory process in managing osteoarthritis (OA) was formulated. Thirty animals were randomly designated to the 6 groups (n=5) as follows: (1) The normal control group (Normal), (2) negative control groups of Monosodium Iodoacetate (MIA), (3) combination ACE-OCE, (4) single ACE, (5) single OCE, (6) positive control group (Diclofenac). Rats received intraarticular MIA injection dose 3mg/0.05 mL on day zero excluding normal control group. All groups were administered topical preparations allotted to each dose group on day 29. Knee edema profile (every 7 days) and serum cytokine level (on day 57) was evaluated with Enzyme-Linked Immunoabsorbent Assay (ELISA). Till day 42, knee edema profile of all group treatment have been similar with normal control group (p>0.05). Serum cytokines level for some biomarkers, such as S100A8 Protein, Interleukin-1β, Inducible Nitric Oxide Synthase (iNOS), matrix metalloproteinase-13 (MMP-13), a disintegrin and metalloproteinase thrombospondin-like motifs-5 (ADAMTS-5), Collagen Type II and Aggrecan Core Protein were decreased. A significant difference compared with MIA group showed for all group treatment on measurement of S100A8 Protein, IL-1β, and iNOS as a biomarker of inflammatory process (#P<0.05). The developed nanoemulgel ACE-OCE either in single or in combination has good physical characteristic and promising effect of anti-inflammatory activity to enhance MIA induced cartilage damage as potential therapeutic agent for OA and encouraging to conduct further studies.

139-145

Authors: Sandeep Singh, Sangeeta Gehlot

Background: Circuit training and Yogasana are good for the development of physical and physiological fitness of an individual. These training methods are useful to develop the individual’s fitness component like strength, speed, cardiovascular endurance, flexibility and agility as well as physiological components like Forced Vital Capacity (FVC), Inspiratory Capacity (IC) and Expiratory Capacity (EC). Thus, this study was planned to find out the variation of cardiovascular endurance, inspiratory capacity and forced vital capacity among sport persons through circuit training and Yogasana practice in different Prakriti individuals. Materials and Methods: 60 young and healthy male of age group 18-28 years, inter university level sport players were selected and divided into three groups, two experimental group (Yogasana and circuit training group) and one control group. Prakriti of each player was determined by the standard proforma. Harvard step test and PFT was done before and after completion of intervention. Result: After intervention significant changes were found in cardiovascular endurance, forced vital capacity and inspiratory capacity. Pair wise comparison of groups resulted in significant difference between circuit training group v/s control group and Yogasana group v/s control group in FVC and IC, circuit training group v/s Yogasana groups in IC. On Prakriti wise analysis significant changes were observed in all the three parameters of all Prakriti players of circuit training group while, Yogasana group showed significant difference in different parameters. No change was found in control group. Conclusion: Circuit training and Yogasana practices produced almost similar response on all studied parameters.

153-161

Authors: Srivastava Kumar Niraj, Saxena Varsha

Background: Cerebral palsy is a disorder of motor control due to a static lesion of the developing brain. It was described almost 150 years ago. Global incidence of Cerebral Palsy is 2 to 2.5/1000 children but in Indian scenario, incidence is 03.8% of population. In India about twenty-five Lakh children are suffering from cerebral palsy. Most common type of cerebral palsy is spastic which cover 70% to 75% of overall. There is no exact correlation found for cerebral palsy in Ayurvedic literature but may be the result of Shiromarmabhighata (injury to brain) and can be considered as Vata Vikara or Vata Vyadhi (neurological disorders). Aim: To assess the effect of certain oral medication with Purvakarma (preparatory procedures) and Panchakarma procedures (Five-fold measures of Bio-cleansing) in the management of Cerebral Palsy (CP). Material and Method: In this case study, one case of Spastic cerebral palsy was registered and treated with multiple Ayurvedic treatment modalities. Total period of treatment was 93 days in which 5 days of Abhyanga (Massage) with Nadi swedana (steam kettle Sudation), 5 days of Abhyanga (Massage) with Shashti Shali Pinda Swedana (a type of Sudation) and then 7 days of Matra Vasti (Enema by Medicated oil in small dose) by Ksheera Bala Taila; this schedule of treatment was given three times with a gap of 14 days. Vacha mula (Root of Acorus calamus) and Samvardhana Ghrita was given as internal medication during the total course of treatment. Results were assessed by progress in delayed milestone, anthropometrical measurement, modified Ashworth scale, muscle power grading and Manual Ability Classification System (MACS) scale. Result: Treatment protocol of oral medication with Panchkarma delivered better result in CP patient, especially improving anthropometric data (weight, height, chest circumference), delaying milestone (walking and language), reducing spasticity and improved Quality of Life (QOL). Conclusion: Cerebral palsy is a disorder of motor function. The cause originates from the brain sometime during its developmental period. Internal medication along with Purvakarma (preparatory procedures) and Panchakarma (Five-fold measures of Bio-cleansing) give significant improvement in all the facets of spastic CP.