Journal of Cell and Molecular Research

1-2

Authors: Muhammad Irfan-Maqsood

Journal of Cell and Molecular Research (JCMR) was first published in 2008 as the first journal in the field of cell and molecular biology research. The need for the establishment of JCMR was felt as a platform for the young cell and molecular biology researchers under the supervision of respective experts. JCMR was established to focus on almost all fields of cell and molecular research and some categorical publications were planned as focusing areas of modern and innovative research done by the young researchers. Genetics, Bioinformatics, Biotechnology, Cell Biology and Molecular Biology were remained the focusing areas of publications in the first five years of JCMR publications. The editorial board has proposed new strategies to increase the impact of the journal of cell and molecular research which include the focused publications and to fasten the peer-review processing of journal. Its indexing in international indexing databases like Scopus etc. will encourage the authors and editors as a milestone in the boosting of scientific quality data production.

13-21

Authors: Abdolkarim Chehregani Rad; Fariba Mohsenzadeh; Hajar Salehi

Chromosome counting was performed in nine populations of Achillea tenuifolia Lam and eight populations of A. bieberestinii Afan (Asteraceae) collected from Hamedan and Kermanshah provinces in the west of Iran. Chromosome numbers in both species varied from 2n=2x=18 to 2n=4x=36. Some populations of both species showed (2n=4x=36) chromosome number that is the first report as polyploidy levels. Aneuploidy is also the first report for both species. Diploid and tetraploid individuals were observed in some populations at the same locality. B-chromosomes were observed in some populations of both species. The results indicated that polyploidy is a common future in this species similar to other Asteraceae plants.

29-37

Authors: Ardeshir Bahmanimehr; Fatemeh Nikmanesh

In certain environments such as Iran highlands, major innovations in lifestyle, as the emergence of agriculture and domestication of animals, are thought to have led to population expansions. Historical studies showed that at some point in history (from the third to the first millennium BC) dramatic changes have been taken place on the Iranian plateau. To trace the genetic affinity between the Iranian Azeris and neighboring populations, 297 samples were collected from northwest of Iran. The non-recombining portion of the Y chromosome (NRY) was genotyped at the unique event polymorphism (UEP) levels, using 48 single-nucleotide polymorphism (SNP) markers, based on the human NRY tree. According to our results, like other Iranian ethnic groups, Iranian Azeris showed a heterogeneous paternal genetic structure. Low genetic distances were also found between Iranian Azeris and their contemporary geographical neighbors. They also have preserved minor share of Y-haplogroup of central Asian ancestry tracts in their genomes, which is in agreement with the historical period of major Turkic migrations. The strategic feature for northwest of Iran to transfer and carry important ancient migratory events and gene flow across the Asia and the Europe also conducive conditions for sedentary habitation leading to sharp demographic growth in the area is supported by all molecular and statistical analysis of this study.

44-49

Authors: Sandeep K Vishwakarma; Syed AB Paspala; Santosh K Tiwari; Aleem Khan

Increasing incidence of central nervous system (CNS) disorders has become a major challenge for both basic and clinical scientific society to develop novel therapeutic models for treatment. The knowledge of stem cells has added a new dimension in the research towards finding more appropriate targets responsible for the disease fate determination. As stem cell research is progressing day by day in routine research laboratories there is great hope to find suitable therapeutic targets for complete cure of the CNS disorders. Discovery of ABC transporters in animal tissues has emerged as new spot for several disease prognosis and therapeutic target. ABC transporters are membrane proteins expressed in various organs like liver, kidney, blood-brain barrier, blood-testis barrier etc. It is involved in various important cellular processes such as absorption, distribution and excretion of drugs, xenobiotics and endogenous compounds showing their role in tissue defense and organ regeneration. The current review explains about the role of ABC transporters in CNS pathogenesis and defense adding stem cells therapeutic strategies.