Current Research in Pharmaceutical Sciences

244-253

Authors: Pravin Pawar and Gharge Varsha

The aim of these research of an oral colon specific, pulsatile device to attain time and or site specific release ofMesalamine, based on chronopharmaceutical consideration. The basic design consists of an insoluble hard gelatin capsule body, filled with Eudragit microcapsules of Mesalamine and sealed with a hydrogel plug. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The Mesalamine microcapsules were prepared in three batches, with Eudragit L-100 and S-100 (1:2) by changing drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule. Different hydrogel polymers were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. In vitro release studies of pulsatile device revealed that, increasing the hydrophilic polymer content resulted in delayed release of Mesalamine from microcapsules. Pulsatile, colon-specific release has been achieved from a capsule device over a 2–24 h period, consistent with the demands of chronotherapeutic drug delivery. Keywords: Mesalamine, Eudragit, microcapsules, Pulsatile, Colon-specific, Chronotherapeutics

258-262

Authors: P Sivakumar, Anil Ahuja and T Venkatachalam

Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis, is the second leading infectious cause of death in world. The study was carried out in the DOTS centre in Coimbatore region.Material and Methods: It was a cross – sectional observational, descriptive epidemiological study. This study was a humble effort to throw light on sociodemographic profile, knowledge and awareness regarding TB among patients with TB. Results and Discussion: A total of 300 patients were included in the study. Majority of the cases (31.66%) belongs to the age groups of 21-40 years. Out of 300 patients, 223 (74.33%) of patients had aware on the aetiology of tuberculosis. Most of the patients 210 (70.00%) were aware of fact that Tuberculosis could be transmitted from one person to another person via coughing and close contact. About 196 (65.33%) of patients had the knowledge about the importance of BCG vaccine for Tuberculosis.Conclusion: Apart from pharmacological treatment, poor knowledge of TB among patients on TB also needs great attention.