Current Research in Pharmaceutical Sciences

7-9

Authors: B K Sarkar, K G Vasanthakumar, P Madhavikutty and V C Deep

Current scenario lead to change in life style which has resulted in the increased production of free radicals which raise the oxidative stress and also play an important role in the immune system dysfunction. Hence there is need of a safe and effective antioxidant. In this regard Varatika Bhasm was screened for the free radical scavenging activity. Various antioxidant assay methods were used for this purpose such as hydroxyl radicals, super oxide radical scavenging activity and nitric oxide radical inhibition. Ascorbic acid (AA) was used as the standard antioxidant for the free radical scavenging assays. The study was carried out for different concentrations of drug in suspension form. The result of antioxidant activities shows significant scavenging of hydroxyl and super oxide radical with the minimum IC50 values of 54.8±0.53 mcg/ml and 91.21±0.22 mcg/ml respectively. Result of study suggested that Varatika Bhasm have excellent antioxidant activity against the different in vitro antioxidant models.

15-27

Authors: Nitendra K Sahu, Kamlendra S Bhadoriya, Mukesh C Sharma and D V Kohli

The QSAR studies were performed on a series of thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline to find out the structural requirements of their antimalarial activities. The 2D-QSAR studies were performed using three methods: MLR, giving r2 = 0.7808, q2 = 0.6492 and pred_r2 = 0.9044; the PLS, with r2 = 0.7785, q2 = 0.6420 and pred_r2 = 0.7181; and PCR, giving r2 = 0.7393, q2 = 0.6222 and pred_r2 = 0.9135. The QSAR models showed that the LUMOEnergy, SdsCHE-index and Quadrupole1 played an important role in determining biological activities. The 3D-QSAR studies were performed using the stepwise variable selection k-nearest neighbor molecular field analysis (kNN-MFA) approach; q2 of 0.7107and pred_r2 of 0.8521 were obtained. The results of the present study may be useful for the designing of more potent analogues as antimalarial agents.

32-34

Authors: D Kumar, H V Hegde, P A Patil, R K Joshi, A K Sharma and S Roy

A formulation of Andrographis paniculata is widely used by traditional healers for the treatment of fever in rural northern Karnataka. The present study was undertaken to evaluate the safety and efficacy of the formulation milk induced pyrexia model. After 1 hr intraperitonial administration of milk, decoction was given in the oral dose of 0.7 ml/kg, which, were shown to be significant in reducing reduced the elevated body temperature of rabbit.