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ANTI-BACTERIAL DITERPENES FROM BORNEAN SOFT CORALS SINULARIA FLEXIBILIS
Authors: TAKASHI KAMADA, WEI-TENG WONG, CHIN-SOON PHAN & CHARLES SANTHANARAJU VAIRAPPAN

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Two new compounds, (13Z,16E)-fuscol (1) and (13E,16Z)-fuscol (2), along with five known and related
metabolites fuscol (3), 18-methoxyloba-8,10,13(15),16(17)-tetraene (4), isofuscol (5), 17,18-epoxyloba-
8,10,13(15)-trien-l6-ol (6) and loba-8,10,13(15)-triene-16,17,18-triol (7) were isolated from the methanolic
extract of Bornean soft coral Sinularia flexibilis (Dinawan Island). Meanwhile, one new compound, (3E,5E)-2-
methyl-6-[(2'R*,4a'S*,8a'R*)-4a'-methyl-8'-methylene-trans-perhydronaphthalen-2'-yl]hepta-3,5-dien-2-
methoxy (8) together with a known compound, (3E,5E)-2-methyl-6-[(2'R*,4a'S*,8a'R*)-4a'-methyl-8'-
methylene-trans-perhydronaphthalen-2'-yl]hepta-3,5-dien-2-ol (9) were isolated from the methanolic extract of
another populations of Bornean S. flexibilis from Banggi Island. The structures of these three new molecules
were elucidated based on spectroscopic methods (NMR, HR-ESI-MS and IR). In addition, their anti-bacterial
activity was evaluated