Neural Networks: Neuroendocrinology and Alzheimer’s Disease
Authors: Bulgakova, S., Romanchuk, P., & Volobuev, A.
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Currently, neural networks are actively used, not only for modern diagnosis and prevention of diseases in geriatrics, psychiatry and neurology, and most importantly – in the application of new methods of neuromodulation in combination therapy (medication, non-pharmacological, etc.) in clinical geriatrics. Neurocognitive actions of sex hormones are carried out in the interaction of neural networks with the cognitive and visceral brain, for neuronet control and multifunctional management, including the balance between their levels, as well as the age and gender of the person. The neuronal action of sex hormones is one of the well-defined pathogenetic factors of Alzheimer’s disease and may represent a hope to understand the neurobiology and neurobiophysics of sexual and age-related variability in predisposition to neurodegenerative diseases. Alzheimer’s disease is a heterogeneous disorder with many variants and a wide variety of manifestations that results from the interaction of many etiological factors, including genetic, epigenetic, environmental and life factors. The effects of estrogen, progesterone and androgen are important ‘building stones’ in the pathogenesis of Alzheimer’s disease, and their impact in the results of the modulation and development of the brain in the different susceptibility of the floor to the disease. These sex hormones, whether gonadal or neurosteroids, play an important neuroprotective role, affecting a person's vulnerability to Alzheimer’s disease, the rate of conversion of moderate cognitive impairment and the rate of progression of this neurodegeneration. Hormone replacement therapy in the prevention and treatment of Alzheimer’s disease is a complex and promising way to build a strategy for the development of personalized, neurocognitive control of the nervous and endocrine systems of Homo sapiens.