Bulletin of Science and Practice

19-24

Authors: Shvannikov V.

The paper deals with the main components of NMR spectroscopy, namely: terminology (chemical shift, multiplicity, and so on) and some examples of software additions (COSY, HECTOR). The theme of this work is aimed at students in the profile of organic chemistry, it allows you to get acquainted with the phenomenon of NMR (in General terms) and decoding spectra without deepening into quantum chemistry and physics. This improves communication and minimizes misunderstandings between the synthetic chemist and the spectroscopic chemist, as this method is one of the most commonly used in determining the structure of organic matter (does not violate the integrity of the carbon skeleton and prevents fragmentation).

31-37

Authors: Mammadova I., Mammadova Z.

The article presents the features of introduction, morphological characteristics and methods of reproduction of Vitex agnus-castus L., depending on the soil and climatic conditions of the Absheron Peninsula of the Azerbaijan. It is determined the dynamics of growth and development, the degree of germination of seeds, the formation of vegetative organs. It was revealed that during the reproduction of the species by cuttings in comparison with seeds, the development proceeds more efficiently. V. aqnus-castus L. grows mainly in moderately humid, subtropical and tropical conditions and in Absheron conditions of the Azerbaijan is subject to a dry subtropical climate, which extends the adaptation process of this species. However, the proper agro-technical care for the plant in the open field contributed to the normal growth and development. V. aqnus-castus L. is propagated by seeds (possibly by autumn and spring sowing) or by green cuttings. Germination of fresh seeds is good, but stored for more than for 2 months need three-month stratification in wet sand by 5°C. The shoots are friendly and saplings.

46-50

Authors: Abramova S., Zaidulina L., Grachev D., Iseev D., Syatkina I.

Family health is an indicator reflecting the health status of the population. According to world statistics around the world about 15% of couples suffer from infertility. The proportion of infertile couples in the Russian Federation varies from 8 to 21%, while more than 55% of cases of infertility are due to impaired reproductive function. Inflammation of the fallopian tubes is one of the main causes of infertility. According to many authors in the Russian Federation, in groups of women up to 38 years old, inflammatory diseases of the pelvic organs occur from 20% to 50%. As a result of the development of damage to the fallopian tubes, the risk of developing tuboperitoneal infertility is high. According to statistics, every fifth woman has chronic inflammations, while 75% of them have adhesions in the small pelvis, in which the fallopian tubes are affected, not even having surgical treatment. All the above facts make the problems of tuboperitoneal infertility extremely low. This article presents the results of a clinical–factor analysis of tuboperitoneal infertility in women of reproductive age. Considered in detail the main factors that ensure the effectiveness and efficiency of the treatment in accordance with the algorithms of therapeutic and diagnostic tactics.

57-72

Authors: Bulgakova S., Romanchuk P., Volobuev A.

Biophysics of blood circulation in Alzheimer’s disease is characterized by disorders of laminar blood flow and cerebral hypoperfusion. As a result, failure intracellular metabolism, there is a cascade of changes in neurons associated with the processes of excitotoxicity and oxidant stress, which in turn stimulates amyloidogenesis. Experimental and 25-year observations have shown that the long-existing state of hypoperfusion leads to hippocampal disorders. This process is accompanied by memory impairment, structural changes in the capillaries in the hippocampus, impaired glucose and protein metabolism, β–amyloid deposition, activation of glial tissue, death of hippocampal neurons. Neuroreflex disruption in the ‘cerebral heart’ and a violation of cerebrovascular homeostasis contributes to the development of vascular dementia through the following mechanisms, including cerebral microangiopathy, endothelial dysfunction, oxidative stress, neuronal damage, the increase in β–amyloid neurotoxicity, apoptosis, etc. The duration of therapy with antiglutamatergic and multimodal drugs in Alzheimer’s disease requires constant multidisciplinary monitoring of targets and medical and social control in the system of long-term care. Lifelong acquisition of knowledge, information positive Nano communication enable the preservation of mental health and active longevity. Innovative methods of P4-medicine of neuroplasticity management allow to carry out timely prevention of the factors reducing neuroplasticity, to keep factors of positive influence on the visceral and cognitive brain, and the main thing — in due time to apply in practical health care the combined methods of preservation and development of the human cognitive brain.

78-82

Authors: Dzhantaeva G., Kudaybergenova G.

A study of plasma hemostasis in 49 patients suffering from bone tuberculosis before and after chemotherapy has been conducted. It was established that in the group of patients older than 50 years after treatment with chemotherapy drugs, there is a moderate hypercoagulation shift in the hemostasis system, expressed in a decrease in the prothrombin index, a decrease in the level of fibrinogen, an increase in the prothrombin time. The aim of the study was to study the indicators of the hemostatic system in patients of different age groups with tuberculous infection of the bone apparatus before and after chemotherapy.

89-95

Authors: Gorshenina E., Veryaskina O., Tugusheva V.

This article is devoted to the study of left ventricular remodelling processes in patients with different duration of hypertension history. The urgency of the problem lies in the fact that not only the increase in the mass of the left ventricle but also the type of its geometric changes determines the risk of mortality of patients from cardiovascular complications. Cardiac remodelling precedes clinical manifestations of heart failure and accompanies them, as well as independently exacerbates the manifestations of diastolic and systolic ventricular dysfunction, is a serious independent prognostic risk factor for arrhythmias, coronary heart disease, strokes and sudden death. We conducted a retrospective analysis of 40 case histories of patients who were on inpatient treatment in GBUZ RM Republican hospital. Depending on the length of the disease, the subjects were divided into two groups: with the duration of the disease up to and more than 10 years. Echocardiography data were used to describe the nature of left ventricular remodelling. Our results showed that the prevalence of myocardial hypertrophy in patients with hypertension is low and is 20% in the group with anamnesis of GB<10 years and 15% — with anamnesis of GB>10 years. In the group of patients with long-term existing hypertension, more pronounced hypertrophy of the left ventricular walls is observed. In the long-term course of hypertension, the development of concentric remodelling and diastolic dysfunction of the left ventricle is an early marker of geometric restructuring of the left ventricle. Early detection of left ventricular remodelling processes is necessary for correct risk stratification and treatment tactics.

105-111

Authors: Esengeldi A., Maimerova G., Mamatov S.

The article presents the results of treatment of 27 children with immune thrombocytopenic purpura in the process of high-altitude climate therapy. All children had approved the final diagnosis and no positive hormone therapy (prednisone) effects. As a result of the ineffectiveness of drug therapy, patients were sent to the high-altitude climate therapy. In the process of high-altitude climate therapy, two children achieved complete and 17 children achieved partial remission. Improvement of clinical and haematological parameters was temporary in 6 children, and lack of effect was registered in 2 children. During the year of observation, no treatment was needed in children with complete, partial remission and clinical and haematological improvement.

121-127

Authors: Shtyrov E., Zotov R., Lapshtaeva A.

The annual increase in cases of oncological diseases dictates the need to search for and develop new methods for diagnosing and treating cancer. The article presents the results of the analysis of modern literature sources devoted to CAR T–cell therapy, which has become a breakthrough trend in the treatment of a number of hematological tumors. The basis of CAR T–cell therapy is the creation of a pool of tumor–specific cytotoxic lymphocytes by introducing an ex vivo transgene encoding a chimeric antigen receptor (CAR). The article outlines the basic principles, possible complications, the advantages and disadvantages of CAR T–cell therapy.

136-144

Authors: Asgarova M.

Considers the economic assessment of the soil. Such indicators as the quality of soil score, tariff category and coefficients for various land acquisition purposes were used as an estimate. The object of study is the irrigated soils of Azerbaijan, which are used for sowing cotton. The price of a hectare of soil was calculated by multiplying the quality of soil score by the tariff for 1 point depending on the soil category. In conclusion, it is concluded that irrigated grey–meadow soils have a yield grade of 100, irrigated meadow–grey — 91 points and irrigated chestnut soils 99 points.