International Journal of Drug Discovery

1-4

Authors: Brindha V., Nazeema T.H.

Reactive Oxygen species (ROS) are believed to be responsible for pathogenesis of various diseases affecting tissues and the main organ, the Liver. Hence, in the present study, the extent of Lipid Peroxidation (LPO) and ROS elimination and its defense mechanisms by the enzymic & non enzymic antioxidants in liver & serum was investigated. Hepatoxicity was manifested by significantly decreased (p<0.05) levels in the activities of the enzymic antioxidants such as Superoxide dismutase (SOD) Catalase (CAT), Glutathione peroxidase and the non enzymic antioxidants such as glutathione & Vitamin C in rats induced hepatic damage by ethanol Simultaneous administration of the leaf extract Mimosa pudica along with the toxin ethanol in rats showed a considerable protection against the toxin induced oxidative stress and liver damage as evidence by a significant increase (p<0.05) in antioxidant activities. The study reveals that the co administration of Mimosa pudica aqueous extract significantly lowered the level of lipid peroxidation in alcohol fed mice.

10-17

Authors: Kayarkar N. A., Durgude S. G., Maurya B.D., Pawar S. V., Chate P. B.

Protein interactions and their specificity play important roles in protein structure and functions. Identification and characterization of protein interfaces is thus important for the study. Adhesive interactions can be considered as one of the key features of many interactions. Computational approach can be applied to great extent in identifying disease specific genes. For instance, Nfat and tat proteins have specific roles related to diseases whose roles can be studied. Apoptosis is considered as a crucial part of many cellular activities and is shown to be related to proteolysis, inflammatory responses, in cancer perturbed protein interaction and mitochondrial dynamics.

28-33

Authors: More M.K., Nair V.K., Thikekar V.P., Sawant J.J., Ravidhone Y., Patil A., Paul Andrea

Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. Protein profiling is recognized & powerful method of classifying new protein families and to use conserved region within multiple alignment of the related protein. The human proteome is dynamic, changing constantly in response to the needs of the body. The proteome also changes in response to cancer and other diseases, making the proteome of great interest to medical researchers. Cancer research ranges from epidemiology, molecular bioscience (bench research) to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy and hormone therapy.

40-51

Authors: Joshi B., Gupta G., Gupta N., Gupta M., Trivedi S., Patil P., Jhadav A., Vamsi K.K., Khairnar Y., Boraste A., Mujapara A.

New drug target discovery is currently very popular with a great potential for advancing biomedical research and chemical genomics. Drug discovery is the process of discovering and designing drugs that includes target identification, target validation, lead identification, lead optimization and introduction of the new drugs to the public. G protein-coupled receptors are one of the most important drug targets. In the current scenario of drug research, approximately 60% of drug target molecules are located at the cell surface, and half of them are GPCRs. Fragment-based drug discovery is established as an alternative approach to high-throughput screening for generating novel small molecule drug candidates. Nanotechnology-based drug delivery systems have seen recent popularity due to their favorable physical, chemical, and biological properties, and great efforts have been made to target nanoDDSs to specific cellular receptors. Protein-protein interactions regulate a wide variety of important cellular pathways, and therefore represent a highly populated class of targets for drug discovery. An analysis of individual proteinprotein interaction systems has recently yielded success in the discovery of drug-like inhibitors.