Journal of Pharmaceutical Research

33-41

Authors: K. A. Gulma, M. Abubakar, B. L. Mohammed, B. Musa, S. Nata'ala, M. I. Yusuf, N. Jibril, S. A. Abdullahi, M. S. Hashim

Purpose – The objective of this research is to assess stock of health commodities used in the management of HIV/AIDS and tuberculosis in Kano State, Nigeria. This assessment will reveal the sum of stock levels available at the state warehouse and health facilities, then determining for how long they can last. Approach – Data from Logistics Management Information System (LMIS) tools for the last quarter of year 2014 were obtained and information on 'stock on hand' and 'average monthly consumption' were extracted for analysis. Computer applications- MS Word and MS Excel were used generate charts depicting month of stock that are used to explain the results. Findings – Prior to the conduct of Quarterly Stock Status Report (QSSR), the best conclusion everyone could make is either a health facility is overstocked or is out of stock. But QSSR brings a clear state-wide picture of the status of all facilities put together which forms the comprehensive outlook of the entire state. Research limitations –The limitation of this research is availability of LMIS data on consumption and stock on hand of other health commodities similar to manner HIV/AIDS and Tuberculosis are recorded regularly. Practical implications - If appropriate action is taken based on the results obtained, there will be leverage of health commodities across the entire length and breadth of the state. Originality –The research is the rst of its kind in Kano and is important not only in assessment of stock status and importance of actions taken from the result thereof but is also very signicant in forecasting and quantication of health commodities.

45-50

Authors: Mohammed Gulzar Ahmed, A. Acharya, R. Chaudhari, K. Panicker, R. Reddy

Objective: The main objective of present study was to formulate and evaluate methyl cellulose based in situ gel of rosuvastatin for the treatment of periodontal diseases. Methods: The rosuvastatin in situ gel was prepared by using different concentration of methyl cellulose as gel base and gel was evaluated for pH, viscosity, rheology, drug content, syringeability, spreadability, drug release and drug release kinetics studies. Results: Compatibility study was performed using FT-IR and results showed there was no interaction between drug and other excipients. Viscosity of all formulations was found in the range of 320-590 centipoise and all formulations exhibited shear thinning pseudoplastic behaviour. Gelation time and temperature was found in the range of 2-15 min and 26oC-39oC respectively. All the formulation except formulation F6, F7 and G8 passed syringeabilitytest, as these formulations easily gets expelled from the syringe. An in vitro release study was conducted using 1.2 pH buffer for 8 hours and results showed that formulation F5 containing 0.9% methyl cellulose was considered as optimum formulation as it released 54.33% drug at the end 8 hours. In vitro release study revealed that release rate of drug from the in situ gel was concentration dependent; as concentration of methyl cellulose increased the drug release rate was retarded. Conclusion:Thus, it can be concluded that formulation F5 containing 0.9%w/v of methyl cellulose as gel base was considered as an optimized formulation, as it release drug in sustain manner in the treatment of periodontal diseases.