VINCULOS; CIENCIA, TECMOLOGIA Y SOCIEDAD

7

Authors: Karina Salvatierra, Hector Florez

Hepatitis C virus (HCV) continues to be a public health problem worldwide. The development of drugs that target virus proteins such as NS5B, aims to provide more effective treatment in the future. These directacting antivirals (DAAs) have demonstrated potent in vitro and in vivo effect; however, mutations have been described in HCV NS5B associated with resistance to DAA. Detecting mutations that are resistant to DAAs is important to prevent potential treatment failures. In this work, we developed a software to analyze mutations that are resistant to DAAs in NS5B gene of HCV. For this, we used the NS5B gene sequence isolate Con1 genotype 1b HCV, based on the main positions mutations associated with resistance to DAAs in vitro and in vivo described in the literature. The software algorithm allows computer analysis of possible changes in nucleotide and amino acid positions associated with resistance mutations to DAAs in NS5B of HCV.

9

Authors: Mauricio Camarena González, Mario Guadalupe González Pérez, Yefer Asprilla Lara, José Andelfo Lizcano Caro

The mercantile exercise of urban planning in Mexico has favored the periurban habitation, with a large number of disconnected and dispersed points in the urban arteries, which has fragmented and configured complex scenarios of motorized mobility. This paper contrasts the potential urban modal exchange in the metropolitan area of Guadalajara with the descriptive analysis of three predefined variables: transport mode connectivity, user transfer and integration in the urban structure; Also, with the use of geo referencing software (QGis) maps were elaborated, defining information in AutoCAD. The results show that in the new trucking center the connectivity and transfer of users of public transport, is low for some municipalities and high for others; Similarly, the design and operation of the roads connecting the study area create barriers to access to non-motorized modes of transport, which endangers the physical integrity of pedestrians, cyclists and people with reduced mobility.

12

Authors: César Augusto García Ubaque, María Fernanda Gil Hernández

Housing is one of the locomotives of a country's growth, therefore the Government of Colombia since the 1930s begins to develop mechanisms that improve the conditions of housing families, although from the middle of the last decade the main growth of population is located in the urban, the National Development Plan 2014-2018, given the peace process, seek to renew life in the country, strengthening the quality of life of the peasants, through the construction and improvement of housing interest Social Rural (VISR), this article is intended to carry out a diagnosis of the political evolution of housing and a review of regulations issued by the national Government for support on issues of housing subsidy, conditions and value requirements housing, saving requested, conditions of families and identification of the entities responsible for the promotion of rural housing and allocation of subsidies. We will find a comparison to show that the national Government should continue to work on strengthening of standards supporting preference-giving entities grant in budgetary requirements more consistent income of farm families, as well as the quantification of the family agricultural units (UAF) opposite the area of land that different households have. Finally, it is important to the consolidation of resolutions, decrees and laws that issued the different entities of the State that affect areas, budget, requirements for the construction of rural social housing.

15

Authors: Julián R. Camargo López, Ernesto Gómez Vargas, Laura Angélica Cadena Contreras

This paper presents the results of the design of a model for the detection and correction of anomalous propagation of a meteorological radar data in equatorial zones, specifically in the Colombian geography. Initially, the decoding of the data measure by the radar was made, then this data got a statistical analysis, this information allowed to define the variables that were used and the weighting of each of them in the developed model. Then the detection and correction algorithm of the model was designed. Finally, a series of tests was developed that allowed validating the proper functioning of the model obtaining margins of error up to 4.67%.