Journal of Acute Disease

1-11

Authors: Xin-Xin Wu1#, Jin-Jian Yao2#, Jin Qian3,4, Qi-Feng Huang3,5, Tang Deng3,5, Shuang-Qin Xu3,5, Hang-Fei Wang3,5, Qi Li3,5, Ji-Chao Peng1 , Yang Yi3,5, Nan Li3,5, Yue Huang3,5, Xiao-Ran Liu1,3,5

Objective: To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019 (COVID-19) vaccination. Methods: We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, CNKI, WanFang Data, and VIP Database from the inception of each database to August 31, 2021. Randomized controlled clinical trials (RCTs) on the safety of different types of COVID-19 vaccines were retrieved and analyzed. A random or fixed-effects model was used with an odds ratio as the effect size. The quality of each reference was evaluated. The incidence of the adverse reactions of the placebo group and the vaccination group was compared. Heterogeneity and publication bias were taken care of by meta-regression and sub-group analyses. Results: A total of 13 articles were included, with 81287 subjects. Compared with the placebo group, the vaccination group showed a higher combined risk ratio (RR) of total adverse reactions (RR=1.67, 95% CI: 1.46-1.91, P<0.01), local adverse reactions (RR=2.86, 95% CI: 2.11-3.87, P<0.01), systemic adverse reactions (RR=1.25, 95% CI: 0.92-1.72, P=0.16), pain (RR=2.55, 95% CI: 1.75-3.70, P<0.01), swelling (RR=4.16, 95% CI: 1.71-10.17, P=0.002, fever (RR=2.34, 95% CI: 1.84-2.97, P<0.01), fatigue (RR=1.36, 95% CI: 1.32-1.41, P<0.01) and headache (RR=1.22, 95% CI: 1.18-1.26, P<0.01). The subgroup analysis showed the incidence of adverse reactions of the vaccination group after injection of the three COVID-19 vaccines (inactivated viral vaccines, mRNA vaccines and adenovirus vector vaccines) was higher than that of the placebo group, and the difference between the placebo group and the vaccination group in the mRNA vaccine subgroup and the adenovirus vector vaccine subgroup was statistically significant (P<0.01). The incidence of adverse reactions after injection of COVID-19 vaccine in subgroups of different ages was significantly higher than that in the placebo group (P<0.01). Conclusions: COVID-19 vaccines have a good safety, among which adenovirus vector vaccine has the highest incidence of adverse reactions. Both adolescents and adults vaccinated with novel coronavirus vaccine have a certain proportion of adverse reactions, but the symptoms are mild and can be relieved by themselves. Our meta-analysis can help boost global awareness of vaccine safety, promote mass vaccination, help build regional and global immune barriers and effectively curb the recurrency of COVID-19.

18-25

Authors: Asuman Ahcioglu, Gulay Yilmazel

Objective: To investigate health literacy, behavioral and psychosocial characteristics in coronary artery patients. Methods: Between March 2019 and 2020 years, 275 coronary artery patients aged ≥50 years were included in the study. Turkish Health Literacy Scale-32 and Beck Depression Inventory were used to collect the data. Results: General health literacy index score was 31.7 and the prevalence of limited health literacy was 59.3%. Adequate health literacy was 2.8 fold higher in the 50-64 age group, 3.1 fold higher among men, 3.4 fold higher among married and 5.3 fold higher among those who believed in the necessity of individual protective practices (P<0.05). Significant differences were also found in different working status, living places, perceived economic situation, perceived general health status, comorbidities, family history of coronary artery disease, angiography history, material skills on reading and understanding, level of depressive syptom, commitment to individual protective practices health check-ups, utilizing health services, cigarette and alcohol use, and exercise and nutrition between limited and adequate health literacy (P<0.05). Logistic regression analysis showed that adequate health literacy was significantly higher among younger patients (OR: 2.81; 95% CI: 1.46-5.62), male gender (OR: 3.10; 95% CI: 1.46-6.58), married (OR: 3.42; 95% CI: 1.39-8.44) and those with belief in individual protective practices (OR: 5.3; 95% CI: 1.93-14.96). Conclusions: Health literacy is poor among coronary artery patients and behavioral and psychosocial variables differ with health literacy levels. To keep cardiovascular health among these patients, health literacy-based interventions should be adopted in coronary artery clinics, especially for risky population.

32-41

Authors: Leila Safaeian1 , Behzad Zolfaghari2 , Zahra Haghighatian3 , Mahmoud Etebari1 , Tahereh Nasirimoghadam1

Objective: To assess the potential toxicity of hydroalcoholic extract of Allium affine (A. affine) aerial parts after acute and sub-acute administration in female and male Wistar rats. Methods: For acute toxicity assay, animals orally received the limit test dose of 2 000 mg/kg of A. affine extract and were observed for 2 weeks. For sub-acute toxicity study, rats were orally treated with 125, 250, and 500 mg/kg/day of the extract over 28 days, and hematological, biochemical, and histological evaluations were then conducted. Results: All rats were alive with normal body weight gain over 14 days, with LD50˃2 000 mg/kg. No abnormality in body weight changes but significant increases in the relative weight of spleen and lung were detected after administration of the highest dose of extract for 28 days in sub-acute assay. Hematological analysis showed prominent elevations in total white blood cells in male rats and neutrophils count in female rats after exposure to 500 mg/kg of A. affine extract. In biochemical evaluations, significant increases in serum creatinine level (female rats, 250 and 500 mg/kg) and in aspartate aminotransferase (male and female rate, 500 mg/kg) and alanine aminotransferase (male, 250 and 500 mg/kg and female, 500 mg/kg) activities, however, notable decreases in serum blood glucose (male rats, 125 and 500 mg/kg), triglycerides (male rats, 500 mg/kg and female rates, 250 mg/kg), and low-density lipoprotein cholesterol levels (male, 250 mg/kg) were found. Histological examinations presented slight portal inflammation in liver tissue, moderate pneumocyte hyperplasia, congestion and peri-bronchial inflammation in lung tissue, and mild histiocytosis and lymphoid follicular activation in spleen tissue after exposure to 500 mg/kg of A. affine extract in male and female animals. Conclusions: The present investigation reveals the safety of A. affine extract at doses of lower than 250 mg/kg in rats and monitoring of lung, spleen, and liver functions is suggested during excessive and prolonged uses.