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Clinical study of adjuvant therapy on ischemic stroke with salviae miltiorrhizae and ligustrazine
Authors: Jing-Qin Tian, Wei Zhang
Number of views: 490
Objective: To study the effect of adjuvant therapy with salviae miltiorrhizae and ligustrazine
injection on neural function injury, degree of oxidative stress reaction, chemotactic factor
and adhesion molecule in patients with ischemic stroke.
Methods: Patients with ischemic stroke admitted in our hospital from August 2013 to
October 2015 were retrospectively analyzed and divided into conventional treatment (CT)
group receiving conventional treatment and traditional Chinese medicine auxiliary (TCMA)
group receiving adjuvant therapy with salviae miltiorrhizae and ligustrazine injection.
After the treatment of the first month and the third month, serum was collected to detect
the contents of nerve injury molecules, oxidative stress parameters, chemotactic factor and
adhesion molecule.
Results: After the 4-week treatment, the contents of serum neuron specific enolase, S100
calcium-binding protein B, heart-type fatty acid binding protein, malondialdehyde, advanced
oxidation protein products, 8-hydroxy-2'-deoxyguanosine, monocyte chemoattractant
protein-1, CD40, CD40 ligand, vascular endothelial cadherin, soluble intercellular adhesion
molecule 1 and soluble vascular adhesion molecule 1 in patients of TCMA group were all
significantly lower than those of CT group, and the contents of superoxidase dismutase,
glutathione peroxidase and catalase were significantly higher than those of CT group. After
the 8-week treatment, the contents of serum neuron specific enolase, S100 calcium-binding
protein B, heart-type fatty acid binding protein, malondialdehyde, advanced oxidation
protein products, 8-hydroxy-2'-deoxyguanosine, monocyte chemoattractant protein-1, CD40,
CD40 ligand, vascular endothelial cadherin, soluble intercellular adhesion molecule 1 and
soluble vascular adhesion molecule 1 in patients of TCMA group were all significantly lower
than those of CT group and the contents of superoxidase dismutase, glutathione peroxidase
and catalase were significantly higher than those of CT group.
Conclusions: Adjuvant therapy with salviae miltiorrhizae and ligustrazine injection can
alleviate the neural function injury, inhibit oxidative stress reaction and the generation of
chemotactic factor and adhesion molecule in patients with ischemic stroke, which is an
effective medicine for treating ischemic stroke.