Asian Journal of Pharmacy and Pharmacology

48-52

Authors: Avinash Gothwal, Ashok Kumar Sharma, Iliyas Khan, Lokesh Gupta, Umesh Gupta

Objective: In the last 3 decades the nanotechnology has impacted researchers with promising results and newer hope in the treatment of complex diseases. Apart from other nanocarriers dendrimers have shown to be one of the most successful nanocarrier as per as the drug delivery is concerned. The present review article is an attempt to comprehensively compile the work in the dual or cocktail delivery using different dendrimers and specially PAMAM. Methods: Bibliographic information were collected and analysed from text books and peer reviewed journals, consulting worldwide accepted scientific databases from the libraries and internet sources. Dendrimers are highly branched macromolecular carriers with the size below 100 nm. The nanometric size and tailor made functionality provides another opportunity for the drug delivery. In the recent past, the dual or cocktail delivery of drugs and genes has opened a new avenue in the treatment of diseases with multiple drug therapy. This is a step ahead possibility shown by the dendrimers which is purely due to its unique features and properties. Conclusion: The applications of dendrimers extends even beyond drug delivery i.e. in diagnostics, non pharmaceutical applications etc. The combined delivery of siRNA and drugs has better potential in overcoming the drug resistance in the diseases such as breast cancer others. Keywords: PAMAM, siRNA, Combined delivery, Drug Delivery

57-61

Authors: Sanjay J. Ingle, K. K. Tapar

Objective: The Quantitative structure-activity relationship (QSAR) analyses were carried out for a series of some 1,2-benzisoxazole derivatives to find out the structural requirements of their antipsychotic activities. Materials and Methods: Multiple linear regression (MLR) methodology coupled with various feature selection methods viz. stepwise (SW), genetic algorithm (GA) and simulated annealing (SA) were applied to develop QSAR models which were further validated for statistical significance and predictive ability by internal and external validation. Results: The statistically significant most excellent 2D QSAR model having correlation coefficient r2 = 0.7249 and cross validated squared correlation coefficient q2 = 0.6941with external predictive ability of pred_r2 = 0.6091was developed by SW-PLS with the descriptors like SaaCHE-index, SssOE-index, T_T_S_7, T_N_O_3 and SsssCHcount. Conclusions: The results of the present study may be helpful for the designing potent analogues as antipsychotic agents. Keywords: QSAR, 1,2-benzisoxazole, antipsychotic agents, VLife MDS, MLR

65-69

Authors: Rajesh Shukla, Gopal Rai, Alok Pal Jain

Objective: The wound healing is a complex dynamic process consists of four integrated and overlapping phases: hemostasis, inflammation, proliferation and tissue remodeling. These phases and their biophysiological functions must occur in the proper sequence and continue for a specific duration at an optimal intensity. The aim of present study was to evaluate wound healing properties of Alpinia galanga rhizomes used in traditional medicine. Materials and methods: The qualitative chemical analysis was performed to detect the presence of different chemical constituents. The petroleum ether extract and ethanolic extract of the rhizomes were formulated as ointment (2% and 5%w/w) and were investigated for wound healing activity by using incision and dead space wound models. Different biochemical parameters i.e. hydroxylproline content and protein content in the skin tissues were determined. Results: Phytochemical screening reveals the presence of steroids, glycosides, flavonoids, carbohydrates and proteins in ethanol extract. Ethanol extract was shows significantly (P < 0.01) faster wound healing up to days 9th day. Various antioxidants enzymes and nonenzymatic substances found increased in healed tissue. The histopathological findings also support with increased fibroblasts throughout the healed tissue. Conclusion: Results were concluded that the ethanolic extract from rhizomes of A. galanga exhibited a definite wound healing effect which can be correlated its antioxidant property. Keywords: Alpinia galanga, wound healing, incision, dead space wound