Ukrainian Scientific Medical Youth Journal

11-14

Authors: Dzevulska I.

Microscopic study in rats, which after burns of the skin 2-3 degrees 21-23% of the surface area of the body were injected the first seven days Lactoproteinum with sorbitol solution at a dose of 10 ml per kg show that microcirculatory disorders, degenerative and necrobiotic changes in endocrinocytes of glomerular, beam and netted area of cortex and brain substance endocrinocytes within 30 days of the experiment were less pronounced than in rats that after burn skin the first seven days were injected 0.9% NaCl solution. Also, unlike the rats that after burn of skin the first seven days injected 0.9% NaCl solution, the injection of Lactoproteinum with sorbitol solution 14 days after the burn of skin in foci of necrosis was present hypertrophy and hyperplasia of fibroblasts and after 21 and 30 days after skin burn - in the connective tissue of cortical and adrenal medulla manifestations of multiple sclerosis are less pronounced.

20-29

Authors: T.Panova, M. Kîshelnik, S.Sherbаk, G. Bîrtnikova, I.M. Karvatskiy, O. Mozheitova, O. Moroz

Different medicines that affect distinct mechanisms of the arterial pressure diminishing are used in clinic for hypertension treatment - neural, humoral. It is unclear why these drugs display different effect in different patients. Impairment of neural and humoral chains of arterial pressure regulation under hypertony of different etiology is suggested to be unequal. Chronic hypertony of different genesis was developed in rats during 4 months: under alcoholism (n=10) and metabolic obesity (n=10). Emotional stress modeled by introducing caffeine. After that hypotensive medicines of different mechanism of action were administered: Concor cor (beta1-adrenergic receptor blocker), Doxazosin (antagonist of alfa1- adrenergic receptor), Prestarium (inhibitor of ACE). These drugs were applied separately of under the stress made by caffeine. Arterial pressure on the tail and the heart rate were registered using sphygmomanometer.

36-39

Authors: O. Mitina

The article is devoted to the problem of the sanitary ecological state of recreational areas. An author on the basis of empiric research's result was developed the draft of comprehensive assessment of the sanitary ecological state of coastal recreational areas. This scheme proposes an analysis of recreational loading and recreants' opinion poll on the issue of the environmental quality and the study of the most important indicators of sea water, sediment, contamination of beach sand by household waste and staging experiments by bioindication with typical representatives of coastal recreational areas. Statistical analysis of the results showed that the most pronounced differences in terms of total suspended solids and solid waste in the area of the beach Omega in compare with the beaches of the north part of Sevastopol, whereas the most pronounced correlation between the indices of the total suspended solids and content of sea water's oxygen (r = -0,965), as well as the total suspended solids and the amount of garbage on the beach (r = 0,753). Between the recreational load and the amount of municipal solid waste has been identified the feedback (r = -0,702). We can assume that this trend is associated with the better cleaning of popular beaches and municipal protection of less visiting areas.

50-54

Authors: S.Tarasenko, V. Smianov, A.Maslenko

In a study to assess the relationship between the number of donors and the amount of blood collected from them in the Sumy region during 2005-2013 years, was used a method of time series analysis and correlation analysis (calculated Spearman rank correlation coefficient). The reliability calculation estimated by calculating the average error rate and reliability. The basis of the study were reporting data of Sumy Regional Blood Transfusion Station and “SOTSSK”. There are such characteristic features of the donation process in Ukraine: 1) insufficient supply of blood, its components and preparations; 2) reducing the “prestige” status of the donation; 3) a small proportion of voluntary unpaid donors in the total amount; 4) the existence of problems with the quality and safety of donated blood; 5) restrictions on the use of effective methods of blood testing. It is proved that the increase in the number of donors in the Sumy region does not cause an increase in blood obtained from donors (Spearman rank correlation coefficient is 0.58, the average error - 0.31 coefficient of reliability - 1.87).bEmphasis in the premises to ensure the quality of blood donation, three levels: system, service, network. At the system level prerequisites that ensure the quality of blood donation, not well defined are the questions of creation of a national registry of donors, the adoption of legislative acts in the field of standardization processes donation, there is no communication strategy to ensure the quality of blood donation. At the service level needs to be improved service organization donors and increase the adequacy of equipment. The network layer is represented by the insufficient number of donors and the need to improve their quality and structural composition. To build a quality management system donation in Sumy region it is necessary prerequisites for development at three levels: system, service and network, allowing purposefully to maintain a certain quality standards in the donation.

58-62

Authors: O. Barabanchyk

To study clinical manifestations in patients with impaired metabolism of uric acid in combination with obesity and non-alcoholic steatohepatitis. The diagnosis of NASH was established on the grounds of exclusion criteria of chronic diffuse liver disease, viral, autoimmune, genetic and medical etiology as the cause of cytolytic syndrome, as well as on the basis of increased echogenicity and decreased conduction liver ultrasound findings. In patients with impaired metabolism of uric acid in combination with obesity and non-alcoholic steatohepatitis noted features such as the presence of clinical manifestations of dyspeptic, abdominal, joint syndrome, and the presence of the phenomenon of “biliary sludge”, which indicates a high risk of developing gallstones.

69-71

Authors: V. Vasyuta

The number of patients with visual impairment in the world is growing steadily. Among the serious ophthalmic disabling diseases special place occupies optic nerve atrophy (ANA). The system of care needs improvement and effective management decisions. Purpose of our study was to justify the management model of medical care to patients with ONA. Materials and methods. The study was based on the experience of providing care to patients with ONA in the department neuroophtalmology SI “Institute of Neurosurgery named after A.P. Romodanov NAMS of Ukraine”. We analyzed data from 4000 patients with ONA, which were sent for further diagnosis and treatment strategy from medical institutions of all levels (primary, secondary and tertiary). We proposed a model management system of medical care patients with ONA. This model has the following elements: organizational, legal, structural and functional, resource economy and takes into account the socio-economic conditions of the region. The basis of organizational and legal integration element is the principle diagnostic and treatment process for optimal interaction between physicians related specialties. Studies management model of medical care to patients with ONA, presented its basic elements, which will optimize the medical assistance given category of patients.

76-78

Authors: Y. Zavodovskyi

. The work is based on the results of examination and treatment of 141 patients treated with renal replacement therapy by PD at the Department of General Surgery and Department of Nephrology of the Oleksandrivska clinical Hospital in Kyiv in the period from 2007 to 2015. Within three years ESI occurred in 67 (47.5%) patients. The most common pathogen in ESI was Staphylococcus aureus - 48 (34.0%) the second most frequently pathogen was Staphylococcus epidermidis - 19 (13.5%). There were no significant differences between categories of ESI and the frequency of infection by various pathogens. After ESI catheter was removed in 12.1% of patients. In all cases of ESI caused by Pseudomas aeroginosa catheter was removed.

85-89

Authors: Kovalenko E., Kovalenko O., Moiseienko V.

This article provides the evidence of the relationship between the meteodependency, as one of the indicators of adaptive reactions of the body, with physical activity and the alarming indicator for the young people. Based on a survey of people aged 17- 25 and its further analytical processing, the results showed that in the non- meteosensitive group the majority of people are engaged in physical activity and vice versa - meteosensitive group consists of people who rearly or never do sports. Perhaps, the physical activity has an adaptogenic effect on the autonomic nervous system due to an improved respiratory function and regulation of vascular tone.

94-97

Authors: I. Kravchenko, N. Turchina

Scapuloperoneal Davidenkovhs myodystro¬phy represents a fairly rare disease nowadays, which diagnosis is sometimes difficult. Scientists still continue to study the characteristics of the mutations that occur in human's body within this disease. Biochemical and pathophysiological processes in the body of patients today have been studied too little. The main problem, which concerns this article, is that the disease in its clinical course may look like Landouzy- Dejerine muscular dystrophy, which occurs much more frequently. The problem becomes more acute because there are controversies among scientists about the place of scapuloperoneal Davidenkovhs myodystrophy amongst others myodystrophies. Some scientists and scientific sources indicate that scapuloperoneal Davidenkovhs myodystrophy is one of the clinical forms of Landouzy- Dejerine muscular dystrophy or a very similar disease. But over the time, the scientists concluded that scapuloperoneal Davidenkovhs myodystrophy is an independent disease, as it has certain features in the clinical course. That is why this article is dedicated to the definition of the main clinical manifestations of scapuloperoneal Davidenkovhs myodystrophy as well as the identification of the main differences of this disease from Landouzy-Dejerine muscular dystrophy. The objects of the study were two families received in patient treatment in the neurological department of the Alexander Hospital: mother and her son, patients with Landouzy-Dejerine muscular dystrophy disease and mother with her daughter with scapuloperoneal Davidenkovhs myodystrophy disease. The results of objective and laboratory researches of these two families, their neurological status, medical history and treatment plan are presented in this article. The Analysis of the survey results of two families has once again shown that both myodystrophies in their clinical flow and development are very similar to each other. Both diseases inherited from the parents of the patients, hit the same muscle groups, are progressing rather slowly, and amenable to symptomatic treatment only. The article describes the clinical and laboratory criteria for differential diagnosis of scapuloperoneal Davidenkovhs myodystrophy and Landouzy-Dejerine muscular dystrophy. On example of clinical cases and also based on review of the medical scientific literature, the main differences between these two diseases are opend. Information on Davidenkovhs myodystrophy, as about an infrequent disease, is also provided separately. Criteria of diagnostics and feature of a clinical course of this disease are also given.

103-106

Authors: E. Nazarenko, A.Radchenko, S. Belal, M. I. Yabluchansky

In 50 patients (25 men and 25 women, mean age - 69,2 ± 12,58 years) with arterial hypertension (AH) influence of biofeedback (BFB) sessions in closed loop of paced breathing (PB) and heart rate variability (HRV) parameters on life quality was studied. All patients were divided into two comparable groups: 1st - 25 patients, where carried out the standard drug therapy, 2nd - 25 patients, where similar treatment was supplemented by 10-day BFB sessions in researched loop with subsequent rhythmic breathing exercises at outpatient stage. Life quality was assessed by questioning of patients before and one month after treatment with the SF-36 questionnaire. The data was processed by parametric and nonparametric statistics. It was found that the systematic BFB sessions in closed loop of PB and HRV significantly improves the life quality of patients with arterial hypertension that allow us to recommend this technique in clinical practice.

115-119

Authors: A. Sakalo

After chemotherapy (ChT) in seminoma patients the residual tumors (RT) of different size and composition could occur. Either ChT or radiotherapy, active surveillance or surgical excision can be administered in this scenario. We present results in 31 patients with RT, and analysis of factors affecting progression. Statistical work out includes logistic regression and Kaplan-Meier analysis. We found that RT sized > 3 cm are more frequently being diagnosed after ChT of disseminated seminoma. When disease progresses (despite salvage- therapy and surgical excision) the prognosis is worse compared to other patients. When alive tumor is found in RT after ChT of second line the prognosis is worse compared to necrosis or fibrosis in the RT. Stage at the beginning of the treatment and spontaneous regression (stabilization of the process) during the follow up are factors confounding the progression. Surgical treatment of RT is technically complicated and associated with high risk of intraoperative complications. Radiotherapy of RT does not improve survival. Long term follow up and active surveillance during many years is justified due to fact of long lasting regression (stabilization) of the RT.

128-131

Authors: V. Revich, T. Shuminska

of blood factors as probable genetic markers investigated tooth decay in 93 people aged 12-14 years. Representation material found on comparative assessment of the frequency of detection of blood groups in 3227 blood donors - residents of Ukraine. Determining genetic markers of blood and saliva conducted in hemagglutination reaction. As a result of genetic and morphological studies the groups at risk of dental caries depending on group membership to the systems ABO (H), P1, MN, Lewis. Found a different structure of enamel, depending on group membership to the ABO system, denser structure of different tooth enamel persons with B5 (III) and ABo (IV) of blood samples of tooth enamel people with O5b (I) and Ab (II) characterized by a loose group structure

138-143

Authors: E. Kovalevskaya, E. Ostapenko, L. Zaprivoda

Department of Histology and Embryology appeared at our university through the work of anatomists. Volodymyr Betz has made an important contribution to the development, so he is fairly called “godfather”. Originally, department located in two classrooms of anatomical corps on Fundukleivska str. (now it is called Bogdana Khmelnitskogo str., 37), but then department was placed in a one-story house nearby. During the evacuation (1941¬1943) department had to be moved into Chelyabinsk. Fortunately, the buildings in Kyiv have been preserved and department has returned in its previous location. When morphological building of the Kiev Medical Institute in Brest-Litovskiy highway 82 (now Peremogi Avenue, 34) was ended, department moved to a new building and is still located there. Everyone who headed the department made an enormous contribution to its development. Only through their efforts the department has become a model, one of the best. Famous histologists: Petro Peremezhko (1868-1891), Yakiv Yakymovych (1891-1904), Fedir Lomynskiy (1905-1924), Olexandr Chernyakhivskiy (1925¬1929), Semen Shahov (1930-1953), Mykola Zazybin (1954¬1975), Kostyantin Kabak (1976-1992) were heads of the department. Since 1992 until now, the department has been being managed by the Corresponding member of NAMN of Ukraine, Professor, MD Yuriy Bogdanovich Chaikovskiy. New scientific discoveries is being made at the department, neyrohistological school continues its life in the works of students and followers. The study of nervous system is continuing, but other systems is being studied too; new embryological research is being held.