Ukrainian Scientific Medical Youth Journal

5-9

Authors: V.D. Vyedyenyeyev, S.T. Omelchuk, O.V Kuzminska, A.M. Grinzovsky

Phytoncidic investigated properties of essential oils of rosemary officinalis, Lavandula and Siberian pine with respect to opportunistic bacteria on the child’s body, and the impact of oil on indicators such as health, activity, mood and morbidity pupils in school. It was done an algorithm of rational usage of essential oils studied to optimize the air environment in classrooms.

17-18

Authors: Litvinenko N.I. , Shcherban M.G. , Kryvonos K.A.

In Kharkiv National Medical University completed two research works (GDR) according to tasks of the Ministry of Health of Ukraine on the themes: “Envi- ronmental and safety study of the optimal levels of anthro- pogenic impact on the recreational areas of watersheds” and “The justification of the waste management concept of risk assessment for health in the watershed of Seversky Donets river”. To study the ecological and sanitary measures for protection of the transboundary watershed of drinking water source in the ukrainian regions and abroad and for improving the conditions of using for public recreation the main recreational reservoir of Kharkiv region Seversky Donets river within the GDR was developed the concept of protection of the water recreational areas and the concept of waste management. It is concluded that the successful implementation of the developed concepts will be possible for fully provided when waste management will become the part of the economic government management at all hierarchical levels and also if the administrative and organizational structure on regional level for resolving problem of organization and control of terms of recovery and mass recreation on the water would be created.

23-26

Authors: Shkolnik E.Ia.

The article describes the age differences anthropo-somatotypological parameters between patients with one- and two-sided acute purulent sinusitis in boys and men without considering and with considering of craniotype. It is proved that the most pronounced differences of studied amount are set between the patient’s boys and men with unilateral acute purulent sinusitis excluding craniotype.

30-33

Authors: Pochinok T.V. , Barzylovych V.D. , Barzylovych A.D. , Gudziy M.U.

The problem of allergic processes prevention by rational nutrition in infants remain unresolved, but highly relevant, because in this period the implementation of major genetically determined mechanisms of allergic diseases happening. The general strategy of nutrition for children with allergic predisposition has two main directions: prevention of early meeting with allergen and food tolerance formation. Unfortunately, quite often the diet in patients with allergic predisposition limited to the strict mother and baby limitations in any food other than breast milk or adapted formulas up to 6-month age. That ensures implementation of the first principle, but completely eliminates the second. This study was aimed at demonstrating the preventive role of rational feeding infants with a genetic predisposition to allergies in the implementation of pathology. We investigated the frequency of manifestation allergic diseases (atopic dermatitis and asthma) in children who were bottle-fed and mixed (received a mixture with hypoallergenic marking of different degree of hydrolysis or adapted milk formula designed for basic use) and breastfeeding (with using or not rigid diet for mothers). Also we investigated the frequency of manifestation allergic diseases (atopic dermatitis and asthma) depending on the time of introduction of complementary first solid foods.

39-42

Authors: Zhukovtseva O.I. , Malanchuk V.O. , Chupurniy Y.V. , Kyseliov V.S.

This article presents the results of studying the interaction of biomorphic ceramics based on silicon carbide with bone tissue in the experiment by scanning electron microscopy. This material was developed at the Institute of Semiconductor Physics VE Lashkaryov NAS by silicon infiltration "channel" carbon matrix, which is produced by the pyrolysis (charring) of various types of wood. To achieve this goal in the experiment 20 rats underwent implantation of laboratory samples of the test material in the lower jaw bone. Animals were removed from the experiment in terms of 7, 30 and 90 days after the start of the experiment, followed by investigation of the surface of the material and the zones of contact with bone tissue. Based on these results, it was found that the studied ceramics microarchitectonics promotes the processes of reparative osteogenesis by providing conditions for colonization kletkok live on the surface of the material. The possibility of coexistence of bone contact and implant of biomorphic silicon carbide with no signs of rejection or its delimitation. In analyzing the results of the contact portion SEM biomorphic silicon carbide with bone tissue revealed adaptation and bone restructuring in the presence of silicon carbide and its germination pore in a material with close fit to the surface.

47-51

Authors: Kucheriavchenko M.

Laproxide L-303 in 1/100 LD50 was shown to exert membranotropic effects, which is indicated by a reduction in adenylate cyclase activity and cAMP contents, as well as an increase in guanylate cyclase and cGMP activity in the brain and liver. The assessment of glutamate/ guanylate cyclase mediator cascade metabolic system condition in the liver showed an increase in both glutamate and guanylate cyclase mediator cascade, while in the brain glutamate was found to be decreasing in the settings of guanylate cyclase mediator cascade increase. Blood plasma assessment showed a decrease in the number of inhibitory and stimulatory amino acids under the influence of laproxide in 1/100 LD50, which can be associated with an increase in reparatory syntheses aimed at homeostasis maintenance in body toxification. The study of receptor bonding indices showed a decrease in variable of dissociation and the number of dopamine and serotonin receptor bonding sites. Therefore, it is possible to conclude that laproxide L- 303 in 1/100 LD50 is responsible for profound reconstruction of intracellular metabolism regulation systems, interfering with neuromediator exchange, kinetic characteristics of radioligand receptor bonding indices in the settings of inhibition of adenyle cyclase and activation of guanylate cyclase mediator cascade. In 1/1000 LD50 laproxide was not found to have an effect on intracellular metabolism regulation systems.

58-61

Authors: N.V. Netyazhenko , A.I. Pastushina , A.V.Lyakhotskaya , O.M. Herula

The article describes the results of a study of hemostasis in women with acute coronary syndrome (ACS) with ST-segment elevation compared to men. 105 patients were examined, 45 of whom were women, On a scale TIMI patients of both sexes were divided into three groups. The I group consisted of 15 women and 20 men with a risk of mortality <1% in group II – 15 women and 18 men with a risk of 1 to 4%, and 15 women and 22 men were the group III with the risk of ≥4%. The groups were comparable. Research methods plasma coagulation hemostasis included the following tests: activated partial thromboplastin time (APTT), thrombin time (PT), fibrinogen concentration, the amount of soluble fibrin monomer complexes, while XIIa dependent fibrinolysis. For laboratory evaluation level of natural inhibitors of blood coagulation following methods were used: determination of the activity of antithrombin III and protein C by a chromogenic substrate. Increased risk of mortality within 30 days in ACS scale T²M² associated with the deepening of gender differences in hemostasis, which are most pronounced in high and very high risk. Simultaneous detection of hypercoagulation shifts in a shortening of the aPTT and PT in the high-risk group of women next to decreased activity of antithrombin III and protein C in the moderate and high risk disclose a violation of the balance of procoagulants with the major components of anticoagulant and fibrinolytic systems in women compared with men ACS segment elevation ST.

66-69

Authors: M.A. Ovdii , V.M. Korshak , E.V. Kostuchenko , K.N. Solomaha , M.l. Perepelytsia

Things that can impair physical fitness and quality of life of students, deserve attention today: physical inactivity, unhealthy lifestyle, lack of knowledge of the problems of recognition and prediction of health risks. Studied physical fitness and quality of life for students. Established that the structural foundation of physical fitness an average level, functional capacity – below average and needs motivation for self-correction. Students who are overweight have a significantly smaller share of their physical and mental health component and this reduces their quality of life.

74-77

Authors: M.S. Stepanchenko , O.S. Fedoruk , O.V Blinder , I.P. Burdeniuk , V.I. Burdeniuk

Exceptionally clinically important is clear understanding of the pathophysiological mechanisms for localization and migration of pathologic microorganisms towards the intact kidney in course of the unilateral inflammatory process. The study aimed to determine the intact kidney’s pathogenic species composition and numerosity in course of rat acute unilateral kidney inflammation, different time frames after the affected organ removal. The experiment was carried out on 54 mature nonlinear white rats Rattus Norwegicus. In all animals an acute unilateral kidney inflammation has been modeled. For modeling of the acute unilateral kidney inflammation in experimental rats, an E.Coli strain was used. The pathogen was previously isolated from urine in patients with the diagnosed urinary tract infection. In order to determine the affected kidney influence on the intact organ microbial contamination, nephrectomy on the affected side was performed on the 10th, 14th and 21st days. Bacterial concentrations in the residual kidney tissue were determined 4, 7 and 14 days after nephrectomy. Control group constituted animals without nephrectomy. Scores were compared to the respective ones of the intact kidney in control group, on the same day of experiment. Reliable changes of almost all microbiologic contamination scores were detected after removal of the affected organ. Infection of the inoculated kidney spread onto intact contralateral organ by the hematogenous and/or lymphogenous routes and persisted there for some specific time. The nature of the infection in the contralateral kidney changed between the 10th and 14th days after inoculation – the agent apparently penetrated the kidney tissue and developed inflammation. Removal of the inoculated kidney timely, before the infection of the intact organ has progressed to its invasive stage, facilitated complete elimination of the pathogen in the contralateral kidney by the 28th day.

81-86

Authors: G.E. Degtiarova , M.V. Khaitovych , L.V. Natrus

The review provides information about the causes of onset of essential hypertension in young people. The main pathogenetic aspects of the disease – an imbalance of the renin-angiotensin-aldosterone system and the interaction of the various systems of regulation of vascular tone – are described. Particular emphasis is put on the role of genetic predisposition, especially to the single nucleotide polymorphisms. Some of the candidate genes, which polymorphisms can lead to the clinical manifestations of hypertension, are described in details. Great association was found between variability of ACE, AGT, AGTR1, NOS3 genes and increased blood pressure. Analysis of the role of single nucleotide polymorphism in pathogenesis of essential hypertension leads to the conclusion that the disease has multigenic character. Study of only one single nucleotide polymorphism as predisposing to essential hypertension cannot be conclusive. That’s why only complex evaluation of different variable genes can give the answer about the endogenous predisposition to disease. Moreover, the influence of environmental factors and their interaction with the genome polymorphism are presented. It can‘t be excluded that genetic factors do not play a key etiological role in the onset of the essential hypertension. Accumulated evidence suggests that genetic background only causes individual susceptibility to development of multifactor diseases such as essential hypertension. Great importance is put on trigger factors such as obesity, salt and alcohol intake, stress, metabolism disorders, low physical activity, and others. Only they under certain circumstances can initiate or accelerate the expression of candidate genes in phenotype. There is strong evidence that polymorphisms of genes may have a minimal effect on the risk of disease in patients with low influence of environmental factors or on the other hand, have the greatest impact in those who are exposed to the excessive activity of triggers.

91-93

Authors: T.I. Nahorna , N.O. Gorchakova , O.S. Lysenko , I.S. Chekman

This review describes new perspective of achieving the combination of nanoparticles of different origin with psychotropic drugs in order to improve bioavailability, the possibility of creating the optimal routes of administration, lower incidence of side effects. The article highlights the results of the influence of nanoparticles on the processes of transport and transformation of medicines in the body that show the improvement of the drugs’ properties and quality of patients’ life. It has been found that the application of nanoparticles of different origin also contributes highly sensitive identification and detection in biological fluids of psychotropic drugs, which opens up a number of prospective implementations in the field of toxicology and forensic medicine.