Studia Universitatis Moldaviae. Stiinte reale si ale naturii

14-19

Authors: Aurelia CRIVOI, Iurie BACALOV, Elena CHIRIŢA, Ilona POZDNEACOVA, Iulian PARA, Lidia COJOCARI, Adriana DRUŢA, Victor CIOCÎRLAN, Ana ILIEŞ, Ana COJOCARI

Thanks to therapeutic qualities which the Diaproptin apipreparate (propolis tincture) holds, currently it can be consi-dered of a colossal value in scientific investigations. Due to the complex chemical structure of natural origin (different flavonoids, amino acids, etheric oils, tanning substances, vitamines, micro- and macroelements) this preparate does not create toxic reactions being especially efficient in the metabolic processes of living organisms. This article emphasizes the bioregulator effect of Diaproptin apipreparate on clinical simptoms in the debut period of alloxan induced diabetes.

26-30

Authors: Victoria BOGDAN, Tudor STRUTINCHI, Maria TIMOŞCO, Aliona VELCIU, Valentina STROCOV

Experimentally under in vitro and in vivo conditions, the beneficial or prebiotic action of the 5th version of food rations developed for the first time at the Institute of Physiology and Sanocreatology on the process of multiplication and development of streptococci intestinal species of the genus Enterococcus, particularly E.faecium, which are of major interest in maintaining the health of the digestive tract as well as for the pharmaceutical industry.

36-41

Authors: Фёдор СТРУТИНСКИЙ, Светлана ГАРАЕВА, Влада ФУРДУЙ, Галина ПОСТОЛАТИ, Валентина СТРОКОВА, Лилия ПОЛЯКОВА, Мариана ЧОКИНЭ, Нина КОВАРСКАЯ

The data about content of oxidized forms of glutathione and carnosine as components of the antioxidant system in erythrocytes of the rats fed with different food rations are presented in the article. The specificity of changes in the concentration of these antioxidants in erythrocytes revealed that the most optimal ration for normostenic rats is ration including: 16% protein, 26% lipid, and 58% carbohydrate (ration 2). Also, the level of glutathione and carnosine in the erythrocytes was maintained at a stable level when the rats received food rations containing 16-20% proteins (rations 2, 3 and 4), fact that indicates the limits of the compensating capacities of rat organism of the normostenic type. Thus, the content of glutathione and carnosine in erythro¬cytes can be considered as an integral index of adaptation processes.

48-55

Authors: Dumitru BULAT, Ion TODERAȘ, Nina FULGA, Denis BULAT, Oleg CREPIS, Nicolae ȘAPTEFRAȚI, Ana DADU

In the present ecological conditions of intensification of the anthropogenic pressing, it has been noted a biological progression in the aquatic ecosystems of the Republic of Moldova of the gobiidae species of Ponto-Aralo-Caspian origin. In this paper, we analyze the diversity of gobies, the ecological analytical indices, the main biological features, the expansion strategies and the necessary measures for the numerical population regulation.

61-65

Authors: Dorina BULICANU

In the process of studying the forest ecosystems it is important to establish the list of synanthrope plant species. This is necessary to establish the degree of influence of the human activity over the environment that have had lead to upset of population and diversity of plant species from downy oak forests. In this article is present the synanthrope plant spe¬cies that includes 204 species from 123 genera and 31 families and presented their bioecological and taxonomic diversity from downy oak forest.

71-75

Authors: Maria FRUNZĂ, Ana BÎRSAN, Tamara BEGU

The present paper aims at highlighting the action of potassium lignohumate on the mitotic division in test plants (Allium cepa L.). The action of five different concentrations of potassium lignohumarate (0.05%, 0.1%, 0.25%, 0.5%, 1.0%) on the germination of onion seeds by analyzing the following parameters: mitotic index, phage mitosis index, germinative energy, root length and stem length has tested. Testing on test plants, on onion, has determined the biosti-mulating effect of potassium lignohumate on the growth and the development of plants, depending on the concentration of the substance. The positive effects of the studied compound have been manifested at the cellular level by increasing the mitotic index and accelerating some phases of the cell division. Increased mitotic activity under the influence of lignohumarate potassium has positively correlated with increased physiological growth and development indices.

82-85

Authors: Alexandru NICUȚĂ

The article presents the results of the research on the influence of the 'Fitomag' preparation on the aging processes - senescence on apple fruit during the long storage-life. As a result of treating the fruits after harvesting with this prepa-ration the processes of biodegradation of the biochemical compounds slow down, the fruit retains its firmness and the degree of damage to fungal diseases and functional disorders is low.

92-96

Authors: Agafia USATÎI, Natalia CHISELIŢA

This work offers new data regarding the relations between the antioxidant enzyme activity – catalase and the para-meters of biomass production and proteins of Saccharomyces cerevisiae CNMN-Y-20 strain under the influence of 10, 30 and <100 nm ZnO nanoparticles. It was established, that the proteins amount and the antioxidant enzyme activity - catalase at the yeast strain at the cultivation in presence of ZnO nanoparticles has changed depending on dimensions and the ZnO nanoparticles concentrations. The 10 nm nanoparticles initiated a relative decrease of the protein quantity in the biomass, values observed at all applied concentrations. The 30 nm nanoparticles have given a positive effect only in the case when were used low concentrations of 1-5 mg/L. The obtained results with the application of nanoparticles with larger dimensions (<100 nm) indicated trends of increase of the protein amount in the yeast strain in contact with 0,5-1 mg/L concentrations, but the 5-15 mg/L concentrations decreased these values. The study regarding the relation between the indices of proteins amount and the catalase activity in Saccharomyces cerevisiae CNMN-Y-20 biomass in contact with ZnO nanoparticles revealed an average and low dependence in function of the nanoparticles dimensions. Thus, finishing this analysis we can assume that zinc oxide nanoparticles, penetrating into the cells cytoplasm, get in contact with cellular components, can determine an acceleration or a delay of biosynthetic processes.

108-112

Authors: Corina CERTAN

In the present paper dependence of the flora of the natural restoration on the sterile dumps surface has been deter-mined according to the consecutiveness, the age of the heaps (25, 20, 10, 5 years) reported the number of species (63, 52, 28, 25 units). The number of species and their degree of development, their abundance is determined by the period of vegetation carpet formation (years) and the place on the dumps surface (margin of the dump, flat land or the down part of the dump). Such a distribution depends on the soil layer formation process. The soil layer is well formed on the flat land surfaces of the dumps. Based on the results the method for the ecological reconstruction of recently deposited sterile dumps deposited by the forest recultivation method is proposed. The inventory of samplings in the autumn of 2017 showed that the percentage of adapted plants is 85%.

121-124

Authors: Natalia CIUBUC, Natalia ONICA

The results of a study on the ways of setting up the monasteries, the history, the role, the functions and the principles of the monastery gardens arrangement are presented, as well as the ways of introducing the "monastery gardens" in the modern landscape.

133-143

Authors: Roman RUSNAC, Olga GARBUZ, Nicanor BARBĂ, Aurelian GULEA, Greta BĂLAN, Olga BRUDUNIUC

The article describes the synthesis methods of 8 organic compounds from the 1,2,4-triazole-3-thiol series, of which 7 compounds are new. The structure of compounds was confirmed by spectral methods: 1H-NMR, 13C -RMN and IR (FTIR). The triazoles (2) and (3) were investigated by X-ray diffraction on monocrystal. Some compounds have demonstrated moderate antiproliferative properties, in growth of HEp-2 and BxPC-3 cells. Antifungal activity is characteristic far compounds (2) and (7) with a MIC of 0.125 μg/mL. Antioxidative properties were studied using the ABTS and DPPH method where the best one was found to be 2-[(2-hydroxyphenyl)methylidene]-N-[4-(3-methyl-5-sulfanyl-4-triazol-4-yl)phenyl]hydrazine-1-carbothioamide (7).

151-155

Authors: Natalia PETROV

New samples of Enoxil (Enoxil I, Enoxil II and Enoxil III) were obtained by oxidation of enotannins. The antioxidant properties of enotannins and Enoxils were determined by means of the chemiluminescence method. It was demonstrated that the anti¬oxidant activity of novel chemical compounds is by 29-32% more pronounced than that of enotannins used as raw material. By applying the potentiometric method of "Boehm titrations" the amount of acidic functional groups (carboxyl and phenolic) in enotannins and the mentioned Enoxil preparations was determined. The obtained results reveal that new substances contain about 3-4 times more acidic functional groups than Enotannins.

162-169

Authors: Maria GONȚA, Elena SÎRBU

N-nitrosocompounds are highly carcinogenic and mutagenic substances formed by the interaction between different nucleophiles (amines, amides) and the nitric acid. NNC formation can be reduced, minimized or prevented completely by the presence of reagents that inhibit the activity of the nitrosating agents or convert them into non-reactive products. The influence of different physicochemical factors on the rate of amoxicillin nitrosation was investigated: variation of nitrate concentration, pH variation of the reaction medium and amoxicillin concentration, antioxidant and inhibitory capacity of various monomeric antioxidants and antioxidant grafted natural polymers. According to the obtained data, all the studied factors changet the reaction apeed of and later they will be used for the inhibition of the nitrosation process.

179-187

Authors: Maria SANDU, Anatol TĂRÎŢĂ, Raisa LOZAN, Sergiu ŢURCAN

The geochemical index (Igeo) of heavy metals in the Prut and the Nistru Rivers, underground sediments as well as their tributaries, characterize the state of the sediments as unpolluted - moderately polluted are those from the natural lakes Beleu and Manta, the artificial ones from Taraclia, Comrat, Cahul and Chisinau city are not polluted with heavy metals (class 0, Igeo is <0 ). It was found a strong pollution with Pb in the sediment of the rivers in Izvoare village, Orhei district (class 4, Igeo = 3.1-3.3) and a moderately - strongly pollution with Cd (class 2-3, Igeo = 2.2 ) in “Unguri-Holosnita” Humid Area small rivers.