49-57
Hydrophilic polyurethane ureas with cycloserine which contain in their structure the fragments of a copolymer of N-vinylpyrrolidone with vinyl alcohol: Synthesis and characterization
Authors: T.V. Rudenchyk, R.A. Rozhnova, N.A. Galatenko, T.O. Kiselova
Number of views: 352
A series of polyurethane ureas (PUUs) which contain in their structure the fragments of copolymer of N-vinylpyrrolidone and vinyl alcohol (VP-VA) with 1,6-hexamethylenediamine (HMDA) as well as a series of polyurethane ureas with 4,4'-diaminodiphenylmethane (DADPh) were synthesized at various percentage ratios of HMDA to VP-VA and DADPh to VP-VA (30:70, 40:60, 50:50, 60:40, and 70:30). Polymer materials with cycloserine were obtained on the basis of the synthesized PUUs, the content of cycloserine being of 1 wt.%. According to the results of IR-spectroscopy, the immobilization of cycloserine occurs due to intermolecular bonds. It was established that the PUUs containing the fragments of VP-VA copolymer in their structure, filled with cycloserine and synthesized at a percentage ratio of HMDA or DADPh to VP-VA of 70:30 show the best physical and mechanical properties (tensile strength of 3.1 МPа and specific elongation of 47% for HMDA and tensile strength of 5.2 МPа, and specific elongation of 90% for DADPh, respectively). Their hydrophilicity is 21.0% and 19.4%, respectively, which will contribute to the prolonged release of cycloserine from the polymer matrix under in vitro conditions.