78-86
Porous polyacrylamide hydrogels: preparation and properties
Authors: N.G. Nosova, V.J. Samaryk, S.M. Varvarenko, M.V. Ferens, A.V. Voronovska, M.I. Nagornyak, S.V. Khomyak, Z.J. Nadashkevych, S.A. Voronov
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The porous polymeric hydrogels are considered very promising for the application in drug delivery, separation and purification of proteins and tissue engineering. Their advantages include the following: high speed of saturation by fluids (medicines, wound exudate, etc.), increasing rate of the drugs release when contacting with the affected areas, reduction of the mechanical irritation of damaged areas contacting with them, the possibility of their utilization for the treatment of deep wounds. The aim of our work was to obtain porous hydrogel materials whose properties, such as atraumaticity, injury-simulate properties and the ability to fill them with medicines, allow their using in biomedical purposes. The article presents the results of our studies that allowed determining the optimal conditions of the preparation and characterization of the hydrogel matrix formation, this matrix being suitable for filling with the appropriate modifiers and fillers. The prepolymers of acrylamide with various molecular weights were synthesized and the rheological characteristics of their solutions were investigated. This allowed optimizing the system for hydrogel obtaining. The porous hydrogels were synthesized via structuring mechanism from previously obtained water soluble and react-capable prepolymers, such as acrylamide and N-hydroxy- methylene acrylamide, under the conditions of stabilizing and forming a porous structure using surface-active co-polyester. The features of their obtaining were studied (such as the ratio of reactants, temperature, structuring time) to ensure controlling their properties as follows: porosity, swelling capacity, physical and mechanical properties. The obtained porous hydrogel materials can be used as transdermal medicines, anti-burn and blood-stopping bandages when they are filled with appropriate drugs.