Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry

6-13

Authors: Irina Shugalei, Mikhail Ilyushin, Veronika Sokolova, Nadejda Dubjago, Irina Bachurina, Alexander Garabadzhiu

The present article provides route of synthesis of complex copper compounds with 1.5-pentamethyltetrazole as a ligand. These compounds are considered promising antioxidants that can fi nd application in treatment and prevention of “free radical” conditions caused by a variety of reasons, e.g. harmful environmental factors. The obtained compounds were rated by their antioxidant potential; the ability to inhibit lipid peroxidation and SOD-like activity thereof were assessed by independent experimental techniques.

23-32

Authors: Viorica Gladchi, Gheorghe Duca, Nelli Goreaceva, Elena Bunduchi, Angela Lis

This article presents the results obtained in the framework of the project 09.832.08.06A The role of the tributaries on formation of the Dniester river water and the study of the waters quality of sources/fountains in the catchment area of the Dniester river as sources of water supply and for irrigation in the State Program, Scientific Researches and of the management of waters quality.

43-46

Authors: G. Torosyan, Ghazi Aidan, N. Torosyan

Phase-Transfer Catalysis (PTC) technology is used in commercial manufacture. PTC is used also in pollution treatment processes. In the paper the synthesis of esters of acrylic, metacrylic acids, which have wide industrial application for production of unique polymeric materials, by phase transfer catalysis method is demonstrated / PTC/. It is necessary to notice, that the synthesis of acrylic acids through PTC is more important because these compounds are more sensitive to acidic and basic conditions. PTC is characterized by a high degree of useful use of substances involved in reaction, smaller consumption of materials and power resources. The work is devoted to technological problems of the synthesis of ethers in the aspect of environment’s protection. The offered method for acrylic ester synthesis, in comparison with the traditional methods, has more advantages including high speed of process, soft condition of reaction allowing reduction of energy expenses, the complete exception of application of hazardous and dangerous organic solvents, by virtue of its sharp reduction of air pollution and reduction of wastewater effluent.

58-77

Authors: Vasile Lozan

A series of novel tri-, tetra- and pentanuclear complexes composed of dinuclear LM2 units (M=Co, Ni, Zn; L=24-membered macrocyclic hexaaza-dithiophenolate ligand) and ferrocene-carboxylate ([CpFeC5H4CO2]ˉ), 1,1’-ferro-cenedicarboxylate([Fe(C5H4-CO2)2]2ˉ), acetylenedicarboxylate, terephthalate, isophthalate, and naphthalene diimide dicar-boxylate groups is reported. The complexes have been synthesized and characterised by UV/Vis-, IR-spectroscopy, and X-ray crystallography. Each dicarboxylate dianion acts as a quadridentate bridging ligand linking two bioctahedral LM2 units via μ1,3-bridging carboxylate functions to generate discrete dications with a central LM2(O2C-R-CO2)M2L core.

83-89

Authors: Popusoi Ana, Barba Nicanor, Gulea Aurelian, Roy Jenny, Poirier Donald, Prisacari Viorel

This paper describe the synthesis of some 1-(alchyl)aril-3-(4-(3-pyridin-2-il) acryloyl)phenylthiourea obtained by condensation of 2-pyridincarboxaldehide with some derivatives of 4-acetylphenilthioureas in basic medium or by addition of aliphatic and aromatic amines to the correspondingisothiocyanatopropenones. 12 new compounds were obtained and their biological properties were analysed. The substituted thioureas by pyridine radicals, morpholine and phenol show a maximum bacteriostatic activity for Gram positive microorganisms like: Staphylococcus Aureus and Enterococcus Faecalis at the minimum inhibitory concentration 9.37-37.5 μM. Antifungal activity for Candida Albicans, Aspergillus Niger, AspergillusFumigatus, Penicillium is weak, in minimum inhibitory concentration 600->600 μM. The leukemia activity like inhibitor (HL-60), is 84-96.9% at the concentration 10-5mol/l and 15- 20% and at the concentrations 10-6, 10-7mol/l.

95-100

Authors: O.G. Kolumbin, L.N. Ognichenko, A.G. Artemenko, P.G. Polischuk, М.A. Kulinsky, Е.N. Мuratov, V.E. Kuz’min, V.A. Bobeica

In our study the dataset containing 489 pesticides and their active substances of different classes of organic compounds was used for analysis. For compounds of analyzed dataset the values of lipophilicity, water solubility, toxicity, bioavailability and mutagenicity were predicted by developed QSAR models. The most environmentally hazardous substances were identified using prediction of QSAR models for pesticides. The satisfactory coincidence between the experimental values of investigated properties and their predicted values by QSAR models was obtained (coefficient of determination in the range 83-94%).