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Retinopathy in Diabetes Mellitus is it due to glycosylation or lipid peroxidation?
Authors: Rama Krishna Reddy Y V , Sushma Reddy V, Amar Nagesh Kumar, Sai Krsihna
Number of views: 362
Aim: To know the leading cause for diabetic retinopathy using simple serological parameters.
Materials and methods: Diabetic patients of age 38-70 with retinopathy were taken as cases and age matched
healthy individuals with age of 37-69 was taken as controls for this study. Fasting and postprandial blood samples were collected for analyzing BG, HbA1C, Lipid parameters, MDA and Vitamin-C. SPSS Software 17 was used for statistical analysis.
Results: The results of cases were compared with a control, shows highly significance for each parameter. Vitamin C showed significant negative correlation with the LDL and MDA. The LDL showed a significant positive
correlation with HbA1C and MDA. TC and LDL showed significant positive correlation with MDA and Significant
Negative correlation with the Vitamin-C.
Conclusion: Hyperglycemia is the cause for glycosylation which independently provokes lipid peroxidation by
decreasing the antioxidant status that neutralize free radicals, so it is the glycosylation and lipid peroxidation plays a main role in the development of retinopathy in diabetes mellitus.