International Journal of Ayurveda and Pharmaceutical Chemistry

5

Authors: Meenakshi Sharma, Ashiya2 and L P Dei

Hyperprolactinemia can be defined as a condition of elevated prolactin levels in blood & it’s prevalence is 3% to 67% in PCOS women. In women, normal range of serum prolactin is 1-25 ng/mL. Hyperprolactinemia causes amenorrhoea or oligomenorrhoea in 30% women with anovulatory infertility. After delivery, it give rise to production of breast milk. In the modern therapy, Bromocriptine or cabergoline are advised which further manifest GIT symptoms, breast pain and painful menses. AIMS & OBJECTIVE – To evaluate the effect of Ayurvedic Drugs in the management of hyperprolactinemia associated with PCOS. MATERIALS & METHODS - An unmarried women aged 28 years with complaints of irregular and scanty menses since 2 years & her Investigation shows altered LH:FSH ratio (>2:1) and confirmed PCOS by USG was treated with Stanayasodhana Gana powder. It was given orally for three month in dose of 6 gms BD with Lukewarm water empty stomach. Along with medication, lifestyle modification was also done. RESULT & DISCUSSION – Serum prolactin levels reduced from 34.73 ng/Ml to 22.87ng/mL & LH, FSH ratio was reduced from >2:1 to 1.2:1. CONCLUSION –It is concluded that hyperprolactinemia associated with the PCOS can be managed through Ayurvedic treatment protocol without any hormonal therapy.

5

Authors: Susheela Choudhary, Sonu2 and Sushila Sharma

Fibroadenomas are benign diseases of breast. It is a benign encapsulated tumour occurring commonly in young females of 15 -25 years of age. Although the peak incidence of disease is between the second and third decades of life, it is not uncommon in postmenopausal women, with an increased incidence after hormone replacement therapy. Presently it is considered as hyperplasia of a single lobule of the breast (classified under ANDI). A 55 years old female visited the OPD of Prasuti & Stree roga, NIA, Jaipur with the complaints of lump feeling and pain in right breast since 1 year. USG report showed mixed echogenic lesion of size 9 × 9 mm in superior periareolar region showing central moving echoes and few minimally ectatic ducts are seen emanating from lesion at 11-12 o clock position shows chronic infective / inflammatory nodule. Based on the symptoms and investigations, patient was diagnosed as a case of Stangranthi (benign breast disease i.e. fibroadenoma). Thus, kanchnar guggulu, Varunadi Kashaya, Haridra khand and Triphala churna were selected for the management and follow up was done after every 15 days. Patient showed marked improvement in all symptoms and USG report comes normal after taking treatment for 3 months. Kanchnar Guggulu, Varunadi Kashaya, Haridra khand and Triphala churna showed significant result in management of fibroadenoma Breast.

6

Authors: Preeti Choudhary, Naresh Jain

Pre menstrual syndrome is a Psycho-neuro-endocrine disorder of unknown etiology also described as Pre Menstrual Tension or PMT. The exact cause is not known but some hypothesis in modern medical science are postulated. Symptoms of the PMS is seen few days prior to menstruation. It may be related to childbirth or a disturbing life event. Up to 80% of women of child-bearing age report having some symptoms prior to menstruation. These PMS is more frequently encountered in middle aged women 30-45years. Also as per the Ayurveda science there is no specific reference of PMS. Artava-chakra or Ritu chakra is classified in three kala due to its specific pattern of Dosha dominancy as Ritukala , Ritu-vyateetkala & Rajakala .The symptoms of PMS can be referred as Ritu-vyateetkala As well as symptoms of Pitta-avritta-vyana vayu in Ayurvedic concept. Pitta-avritta Vyana vaayu can be managed by the line of treatment of Avarana.

7

Authors: Rashi Sharma, Sunil Kumar2 , Sandeep M. Lahange

The science of Marma is one of the special facets which is intensely elaborated in Ayurveda. Marma are vital points on the body which when injured or traumatized leads to deformity and sometimes even death. Although Marma points are said to be fatal but they are also considered as seat of Prana. So, Prana stimulation or flow of energy can be regularized by means of Marma therapy. In present era in spite of various treatment modalities in orthopedic field, we came across various types of post treatment deformities in case of joints trauma. By the collaborative approach of modern modalities and Marma therapy we can get much better results in restoring the joint abilities. Working in this direction it is very much required that we explore the Marma as they are given in very concise form in classics of Ayurveda. So, in this paper we have put our utmost efforts to elaborate the anatomical location, structure, traumatic symptoms of Kurpar Marma with the help of both Ayurveda and Modern Literature. This will lead to better understanding of Kurpar Marma and ultimately advancement in Marma therapy with relatively less occurrence of deformities.

7

Authors: Varsha S Dhage, Pratibha Chougule

The tongue is a vital organ for chewing and swallowing food, as well as speech. The tongue is an important accessory organ in the digestive system. Therefore, it deserves proper care and maintenance. If we neglect, then it can affect the rest of the mouth. Oral cancer is becoming the most common disease in the world. Besides this, there are various types of tongue disorders, which are also becoming a big problem for the populations. In Ayurveda, cleaning of the tongue (Jivhanirlekhana Karma) has been described to maintain tongue hygiene, to prevent tongue disorders & also to improve digestive system. So, here we have discussed about the common tongue disorders in Ayurvedic as well as modern aspects.

8

Authors: Matangee Pandya, Shilpa B. Donga2 , C R Harisha3 and V J Shukla4

BACKGROUND Punarnavadi Guggulu is a combination of herbal drugs having a numerous number of references with different contents in ayurveda classics. But its qualitative data hadn’t been explored thoroughly yet. It is indicated in Twagdosha, Shotha, Udara, Panduroga, Sthaulya, Prasek and Udhwakapha Amaya.It is also used gynecological disease, Pelvic Inflammatory Disease, Genito urinary tract infection and in disease where according to ayurveda Pitta-Kapha Doshas are vitiated. AIM - To develop pharmacognostical and pharmaceutical profile of Punarnavadi Guggulu. MATERIALS AND METHODS - Study included preparation of Punarnavadi Guggulu following all SOPs using raw drugs, which were previously authenticated. Later, Punarnavadi Guggulu was subjected to pharmacognostical, physicochemical and HPTLC analysis as per standard protocols. RESULT AND DISCUSSION - The pharmacognostical study revealed the presence of starch grains, starch cells, rhomboid crystals, tannin, lignified fibers, stone cells, epidermal cells, cork cells, border pitted vessel, Chollenchyma cell, crystalline material, etc,. Pharmaceutical analysis showed that the average weight 320.7 g, Maximum weight was 357 g, Minimum weight was 251 g, loss on drying value was 11.5% w/w, Ash value was 10.9% w/w, Acid in soluble extractive was 3.51 % w/w. Disintegration time was more than 1 hour, Water soluble extract was 30.24% w/w, Methanol soluble extract was 20.12% w/w, pH was 5. Methanolic extract of Punarnavadi Guggulu shows presence of carbohydrates, steroids, cardiac glycosides and alkaloids. HPTLC fingerprinting profile was revealed 9 spot in both 254 nm and 366 nm. CONCLUSION - The present investigation will be helpful in assessing the pharmacognostical, phytochemical analysis and laying down pharmacopoeial standards for Punarnavadi Guggulu.

8

Authors: Priya Darshani Koul, Yadavendra Yadav2 , Usha Sharma3 , Shuchi Mitra4 , and Khem Chand Sharma

Bhaishajya Kalpana is the branch of Ayurvedic medicine that deals with the collection, selection, purification of drugs, study of their nature and combination as well as preparation, preservation and posology. Ancient extraction techniques had been in practice under this branch. Herbs show pharmacological action by means of their active ingredients. Depending upon the type of active constituent of the drug, different extraction techniques are being used. With the evolution of Panchvidha Kashaya Kalpana in Samhita kala, the extraction of crude drugs came into light. In modern pharmaceutical science, there are many advanced and refined techniques for the extraction of active ingredient(s)/principle of a drug. And various researches are being done to extract the active ingredient(s) of a drug to increase its potency and decrease its dose. Although new extraction technologies are on the rise, having both advantages and limitations, conventional extraction methods have their own edge. The present paper is aimed to focus on the chemistry of these conventional methods.

9

Authors: Matangee Pandya, Shilpa B Donga2 , C R Harisha3 and V J Shukla

Introduction Panchavalkaladi Taila is described in charak samhita in Yonivyapad chikitsa Adhyaya. Panchavalkaladi Taila is containing Vata, Udumbara, Pipala, Plaksha, Parisha, Shallaki, Jingini, Jambu and Dhava, which have properties of Kashaya and Tikta Rasa, Sthambhaka, Shothahara, Vranaropana. It is indicated in Vipluta, Upapluta and Paripluta Yonivyapad. This formula can be use in all infectious and inflammatory gynecological disorders i.e. pelvic inflammatory disease, valvovaginitis, white discharge, etc. Panchavalkaldi Taila is a less explored formulation and so it is to be studied in details for standardization of its qualitative analysis. Aim The present study was aimed to set a manufacturing protocol and to develop pharmacognostical and pharmaceutical profile of Panchavalkaladi Taila Materials and Methods Preparation of Panchavalkaldi Taila, all SOPs using raw drugs i.e. previously authenticated raw drugs, subjected to pharmacognostical, qualitative parameters and high performance thin-layer chromatography (HPTLC) analysis as per standard protocols were included in study. Result and Discussion The pharmacognostical study revealed the presence of characteristics features of all the drugs present in the composition. Pharmaceutical analysis showed that specific gravity at 400C is 0.9163, Refractive index at 400C is 1.48, Acid value is 3.2712, Saponification value is 150.24, Iodine value is 86 g. HPTLC fingerprinting profile of Panchavalkaladi Taila revealed 08 spots at 254 nm and 05 spots at 366nm. Conclusion The present investigation will be helpful in assessing the pharmacognostical and phytochemical analysis for Panchavalkaladi Taila.

10

Authors: Jasobanta Dansana, Kishan Singh

Life style disorders refer to diseases associated with the way a person or group of people lives. Diet and lifestyle are major factors thought to influence susceptibility to this kind of diseases. With rapid economic, technical development and advancement in every field and especially increasing westernization the lifestyle of common man has completely changed which is leading to many common health problems notably stress, obesity, hypertension, diabetes, allergic disorders and thyroid disorders and many more. Lack of exercise, use of preserved and junk food, smoking habits, and alcohol intake also increase risk of developing these types of diseases esp. later in life. The pragyapradha which has been mentioned as one important causative factor for the production of diseases is mainly responsible for lifestyle disorders. Ayurveda being science of life describes the basic things like dinacharya, ritucharya, aahara and vihara for the maintenance of health and prevention of diseases. Recently discovered SARC-COV-2 virus is a reason for a contagious disease called Covid-19, which is started from Wuhan, China on December 19, which is spreading to the entire world. World health organization declared it as a Pandemic disease. Not only its high rated of disease person but also spreads fast, its treatment is based on symptoms the important part is the vaccine is not developed yet. So, the whole world is looking towards Ayurveda for its preventive as well as a curative aspect. Ayurveda has mentioned Pandemic disease under the heading of Janapadodhwansa and Infectious disease under Jwar (all typesof fever), Kustha (skin disease), Agantuj (Disease due to external factor), Bhoot graham pida (Disease due to external factor). Ayurveda is the mother branch of medical science; it gives brief treatment not only on physical levels but also at psychic and spiritual levels. Now time shows Ayurveda principles in front of the world.

10

Authors: Ekta Sharma, Nitika Sharma2 and Vinod Kumar Gautam

Oral cavity is considered to be the mirror of body’s internal mechanism. Hence a lot of efforts must be made to keep it healthy from chronic conditions which may lead to not so pleasant results. One of such chronic debilitating condition of oral cavity involves the formation of constricting bands of collagen fibre, build in a progressive manner in the oral mucosa resulting in restricted movement of mouth and tongue ultimately leading to hindered or problematic speech and difficulty in swallowing food termed as Oral Submucous Fibrosis (OSMF). In modern parlance, many medicinal and surgical modalities have been put forth in use but the results yielded are not much satisfactory and on the other hand owe to recurrence and adverse effects. On analysing the symptomatology of OSMF with Ayurvedic classics, it can be considered as Vata Pitta Pradhana Sarvasara Mukharoga. Here, an effort was made to treat a 65 years old female, well diagnosed case of OSMF through Ayurvedic modalities. In this case study, patient was treated at both local and systemic level. Local modalities like Vrana Shodhaka and Vrana Ropaka Pratisarana (Rubbing) & Kavala (Gargling) stop the progression of the disease and these local therapies prevent and reverse the fibrosis and improve the muscular movements of mouth. Systemic therapy brings homeostasis and enhance the vitality of the oral mucosa. This case report showed that Ayurvedic treatment modalities are promising in the management of OSMF and capable of increasing the quality of life of the patient.

11

Authors: Aniket Anil Shilwant, Purva Sushilkumar Bharde

Charak Samhita is one of the ancient and globally accepted treatise on medicine from the school of Ayurveda. The arrangement of the contents of this treatise is worth to be appreciable. In Sutra Sthan, Roga Chatushka is the tetrad of chapters from Charak Samhita explaining diseases, where Maharogaadhyaya is one of them. It is noteworthy that, the ancient scholar Acharya Charak had a keen knowledge of numerology and systematic presentation of contents too. The validity and authenticity of the contents is proven from time to time till date. Tridosha is the cornerstone of the Ayurveda which are seen as group of properties coming together due to sharing of similar elementary origin. Dosha have certain group of properties which are not separable from the preformed cluster, this is Atma Guna. So, Dosha by the virtue of this Atma Guna are having typical tendency to create a typical set of symptoms. This is seen in any diseases when looked into subtypes formed due to Dosha. This article highlights the contents mentioned in Maharoga Adhyaya of Charak Samhita in terms of extensive ability of Dosha to create numerous diseases.

17

Authors: Rekha Phull, Gaurav Phull2 and Dimple Agarwal

At present, the whole world is struggling in dealing with the sudden outbreak of pandemic of COVID-19. The healthcare system across the globe is found wanting and inadequate. Ayurveda has been the benchmark of healthcare system of India for ages. The rich heritage of our ancient science was certainly overlooked and ignored to some extent in last century, due to emergence of Allopathic system of medicine. The literature of Ayurveda has ample references of epidemics/ pandemics, different pathogens and anti-viral remedies, which clearly indicate towards the potential of Indian system of medicines to deal with viral infections in an efficient way and this is now being explored in form of various clinical trials. The herbal remedies are a boon for improving immunity. In present scenario, China has dealt with this viral outbreak using its traditional medical system along with western science quite efficiently. In India however, the Indian system was majorly kept aside initially, but gradually its importance was appreciated by the government and at present utility of AYUSH is being explored by encouraging the trials. This is a welcome step as the modern science is also not very sure about the definitive treatment and they also are trying to manage with different combinations. Therefore, in this paper we will try to highlight the importance of our ancient medical system in dealing with this menace. Material and Methods: The required data was collected from library of our institutes, online publications, Web-portals like Medscape, current news updates, AYUSH website and ancient texts of Ayurveda. Conclusion: There are still some unexplored areas in potential of Ayurveda to manage this pandemic more effectively. Vast potential of Indian system of medicine is a definite advantage in strengthening the available workforce of health system in our country to boost our fight against the present outbreak.