International Journal of Ayurveda and Pharmaceutical Chemistry

5

Authors: Megha G, Divyasri R A

Skin is the largest organ in a human body. Dermatological problems are diagnosed by Paediatricians on a daily basis. Psoriasis is one of the most common dermatologic diseases, affecting about 1 to 2% of the world’s population. Most of the skin diseases in Ayurveda have been mentioned under the title of Kushta which have Saptakodravya sangraha. Kitibha Kushta is one of the chronic conditions, which requires repeated shodhana and shamana chikitsa. Newer approaches are to be sought to have a quicker and better healing of lesions and also to prevent its recurrence. This paper highlights the effect of Ikshu rasa basti in a case of Kitibha kushta (Psoriasis).

5

Authors: Chaya H, Manjula K, Mahamad Yunus S Nabooji and Prakash B Shivapur

Thyroid problems are among the most common endocrine disorders presently seen worldwide.Thyroid hormone regulates the metabolic action of the body. Improper secretion of thyroid hormones by thyroid gland leads to thyroid disorders. Gandamala being one such disease having an eagle sight, one can conclude out that how modern era is influencing both body & mind status of the individual. Based on clinical features of Gandamala can be considered as thyroid disorder and is one among the mamsapradoshaja vikara. Hence in this study an attempt is made the observation of thyroid hormone changes in Gandamala. After the study it was observed that, T3 and FT3 were found raised in the clinically diagnosed cases of Gandamala. Thyroid function test with raised T3, FT3 and normal T4, TSH, FT4 can be considered as supportive diagnostic tool for Gandamala.

6

Authors: Atal Singh Kushwaha, Rajeev Shrivastav and Nitin Ujjaliya

This article reviews the approaches for bridging classical Ayurveda facts with clinical diagnosis. In doing so author extracted some useful concepts from the classics and tried to corelate them and apply them in clinical practice. Now a days new young graduates seems under confident and does not showing much interest in practicing Ayurveda for the society. This concept of tri sutra and its clinical relevance can play an important role in enhancing their faith and interest in practice, for that tri sutra concept i.e the unite of hetu linga and aushadha with knowledge of sroto-vigyan can be made clear and understood with their clinical applicability. Ayurveda science operates through tri skandh for both diseased and healthy persons. Unlike western medicines Ayurveda doesn’t deals in a standardized way or on a common note rather its person centered medicine science (purusham purusham bheekshy). Hence a soul ayurvedic understanding of a disease needs to be understood with its clinical correlation.

7

Authors: Anil Tomar, M B Gaur

According to Ayurveda human body is structured with different types of srotas. The term Srotas means channels or networks which are basic and essential parts of body. All srotas are closely connected with their particular origin (mulasthan). Mulasthan of srotas are the sites of utpati (formation), vahan (transportation) and sangrah (storage) of a particular constituent to which the srotas belongs. Rakta (blood) is one of the important functional connective tissue of body of which formation, transformation and transportation is carried out by raktvaha srotas and the mula of the raktvaha srotas are Yakrut and Pleeha. For blood circulation modern science especially mentioned the cardiovascular system, liver as a most important metabolic gland and spleen as lymphoid organ and part of reticuloendothelial system. Blood related concepts like – formation of RBCs (hemopoiesis), destruction of RBCs and reservoir of RBCs is rooted in liver and spleen (pleeha). In this article, the relationship between Pleeha (Spleen) and Rakta (Blood) is studied. Also, an effort has been made to discover the reasons for mentioning the Pleeha (Spleen) as mulasthana of raktvaha srotas.

8

Authors: Chaitra L V, Krishnamurthy M S and Jayalaxmi

Rasashastra a branch of Ayurveda that deals with Metals,Minerals,visha dravyas,animal origin drugs, Herbomineral/Herometallic preparation and it is emphasizing on various pharmaceutical process such as Sodhana, Jarana, Marana, etc samskaras for the better pharmacodynamics action. In Ayurveda, treatment is of three types that are Daiwa (therapeutics), Manushi (medicinal therapy), Asuri (therapy involving various hymens and rituals). Rasa oushadis (Herbomineral, Herbometallic) which comes under Daiwa chikitsa. Rasa oushadis are more effective with low dose, having palatable, quick action and it can be used to treat asadhya vyadhis. Atisara is a condition where watery stool (drava mala) are passed in excess several times a day through anus. In Rasashastra classics, a handful of Herbomineral formulations are indicated in Atisara. Almost 10 rasa yogas have been mentioned in Atisarahara adhikara of Bhaishajya rathnavalli, 18 rasa yogas in Abhinava Chintamani, 10 rasa yogas in Vaidyachintamani, 4 rasa yogas in Yoga Rathnakara and in Rasendra Sambhava, 6 rasa yogas in Rasa rathna sammuchaya are indicated in Atisara. Here an attempt made to compel the Rasa oushadis indicated in Atisara from few Rasa classical texts. The review indicates that the Rasa oushadis can be administred in different condition of Atisara with different anupanas and which are therapeutically effective.

8

Authors: Nirmala R Sonawane, Sima A Kurule, Lata A Rathod and Sandip LAute

Panchkarma being Ayurvedic treatment modalities gaining top rank in the treatment priority list of the patients now a day. As a result, almost every Ayurvedic physician desires to attract patients by providing various Panchakarma therapies. A Panchakarma treatment requires concise precision but is being modified to suit a contemporary lifestyle. Basti chikitsa is the most widely among Panchakarma and the most common degenerative disease-Janusandhigata vata in which basti is the most promising treatment was selected for the study. A randomized open single blind controlled prospective clinical trial was undertaken on 60 patients suffering from Janusandhigat vata to compare the traditional and recent methods of basti daan vidhi (drug delivery) and also to treat Sandhigat vata, Erandamool niruha and Tila taila anuvasan was used in yog basti manual. The patients were divided into 2 groups of 30 each. To group A (study group) basti was given by the traditional method and group B (control group) basti given by recent method. Clinical facts obtained from the study were analyzed with appropriate statistical methods. The present study provides strong pieces of evidence that prove the effectiveness of the traditional method of basti daan over the recent methods in several aspects.

9

Authors: Lekhan K G, Mohammed Faisal2 and Niveditha Shetty

Aushadhavacharana refers to application of different Dravya in various vikara. Vikara is of two types Samanyaja and Nanatmaja vikaras. Kaphaja rogas have been given prime importance in classical literatures of Ayurveda. While treating any disease, selection of right, potent and useful drug is very important, here role of Pancha padarthas of Dravya plays an important role. The drugs having Katu, Tikta, Kashaya Rasa pradana, having Gunas like Laghu, Ushna, Ruksha, Tikshna, Vishada, Sukshma, Khara, ushna Veerya, Katu Vipaka can be selected for treating Kaphaja rogas effectively. The action of the Dravya is either by any one of the above Pancha padarthas or in combination, hence before selecting the Dravya to treat the disease proper, examination of Roga and Rogi is must. An effort is made to compel the knowledge about different avacharanas based on various concepts of Dravyaguna which can be selected by vaidya in treating Kaphaja rogas to get the fruitful results.

9

Authors: Hemlata Dixit, Anita Sharma, Mukesh Shrimal and Amol Kadu

Dadru is one of the common skin disease mentioned in ayurveda. In modern science the clinical manifestation of dadru is closely similar to local fungal infection/tinea infection which is affecting upto 15% of population. Excessive severe itching and red patches are the common clinical manifestation which can be diagnosed by darshana and prashanapariksha. Potassium hydroxide microscopy and fungal culture are the specific tools for diagnosis of fungal infection. Lepanaand Shamanachikitsa will help to cure Dadru.

10

Authors: Pallavi V Kashyap, Shrikanth P, Niveditha Shetty and Suchitra N Prabhu

Objective: To determine the Pharmacognostic and Phytochemical analysis of the whole plant of Matsyakshi(Alternanathera sessilis (L.)R.Br.ex.DC) and to analyze its results. Materials and Methods: Whole plant of Matsyakshi was examined for its macro-microscopic features and pharmacognostic standardization parameters were determined according to WHO guidelines. Parameters such as loss on drying, total ash, acid insoluble ash and extractive values were determined. The preliminary phytochemical tests and HPTLC were performed for the identification and standardization of Alternanthera sessilis. Conclusion: The odor, color, surface texture of the plant was noted. Microscopic characteristics revealed the presence of starch grains in T.S of leaf, trichomes and rosette crystals in T.S of Stem,Preliminary phytochemical tests revealed the presence of steroids, tannins and coumarins. HPTLC analysis revealed that there are 11bands in long UV range, 5bands in short UV range and 5band after derivatization. In densitometry scan 10peaks at 254nm, 13peaks at 366nm and 8peaks at 620nm. The long UV range had more number of bands and fewer bands in short UV range.

12

Authors: Vidyarathna K H P M, Kulatunga R D H and Madhumalika L P C

Lekhaneya Dashakaya is mentioned in Charaka Samhita and it has Lekhana (scraping /corrosive action) potentials are practiced for reduction of body weight. It consists of ten ingredients as, Musthaka, Kushtha, Haridra, Daruharidra, Vachaa, Athivisha, Katurohini, Chitraka, Chirabilwa. and Haimawathi. The present study has been focused to find out Pharmacodynamics and pharmacokinetics potentials of ingredients of Lekhaneya Dhashakaya and develop the hypothetical samprapthi of Athisthaulya. The secondary data was collected by authentic texts of Charaka Samhita, Ayurveda Aushadha Samgrahaya book series, Ayurveda Pharmacopeia of India book series, related web sites and scientific journals. Results revealed that Tikta (90%), Katu (80%) in Rasa, Laghu (100%), Ruksha (90%) in Guna, Ushna Veery (90%), Katu Vipaka (100%) and Kaphavatahara (50%) in Dosha karma were prominent pharmacodynamics potentials in Lekhaneya Dashakaya. Lekhana(100%), Deepana,(80%), Kaphaghna(70%), Pachana(60%), Krimighna(60%), Twak doshahara(50%), Shotahara(50%), Vedanasthapana(50%) and Jwaraghna(50%) were major pharmacokinetic potentials and hypolipidemic action (100%), anti-inflammatory action(90%), anti-diarrheal action(80%), hepatoprotective action(80%), anti – microbial action(80%) , hypoglycemic action (80%), anticancer (70%), anti-oxidant activity(70%), immunomodulatory action (70%) and anti -ulcer (50%) were the prominent pharmacological actions. While, Ruksha, Teekshna qualities cause to penetrate deeply in tissue level and scrap vitiated excessive accumulated medas due to Lekhana action, Kaphaghna action helps to expel excessive kapha and Amapachana and Agnideepana restore Jataraghni and Dathvagni. In addition, pharmacodynamic potentials and pharmacological properties of Lekhaneya Dashakaya have exhibited characteristic similarities. Thus, it can be concluded that Lekhaneya Dashakaya could be used in treating the Athisthaulya and it show multidimensional approach.

13

Authors: R. Padmavathi, Nousheen Fathima2 and Mohammed Abdul Samad

The goal of the current research was to explore the beneficial effect of integrating allopathic, ayurvedic, and probiotic treatment in acetic acid-induced ulcerative colitis in rats. Wistar rats of either sex were divided into six groups. Group I received a single dose of vehicle rectally, group II received 2 ml of 3% v/v of acetic acid in 0.9% saline rectally, group III received mesalazine (100 mg/kg/p.o), group IV received Grahi (10 mg/kg/p.o), group V received mesalazine and Grahi and group VI received mesalazine, Grahi and sprolac (100 mg/kg/p.o). The Disease Activity Index (DAI) was measured during the treatment period. Blood was withdrawn white blood cell and differential leucocyte count at the conclusion of the research. The animals were sacrificed at the end of study period for the evaluation of intestinal inflammation, colonic microbial count, myeloperoxidase concentrations and histopathology under ether anesthesia. Combination treatment displayed a major beneficial impact relative to monotherapy in relieving colitis. Especially in comparison to monotherapy, total improvements in DAI, inflammatory ratings, white blood cells count, colonic microbial count and myeloperoxidase indicated a substantial improvement, reflecting the preference for combined therapy. Although monotherapy has also been successful in improving colitis, combined therapy has been even better. In colitis, the application of mesalazine and Grahi may be more helpful than monotherapy. In order to produce the most effective result in the treatment of colitis and other inflammatory intestinal disorders, probiotics may be prescribed as an adjuvant to the mixture of mesalazine and Grahi.

15

Authors: Khandate B. Maheshchandra, Amolshah M. Madavi2 and Patil Shilpa S

The present study was conducted to compare the efficacy of gomutra yukta vaitarana vasti with dhanyamla yukta vaitarana vasti in the management of katishoola in 40 patients (20 in each group) from Govt. Ayurveda College Hospital, Tripunithura. Vaitarana vasti is one of such treatment modalities of Panchakarma which is directly indicated for vatavyadhis. It is mentioned in Chakradutta- Niruha-adhikara (73/32) and Vangasena - Vashtikarmadhikara (83/186-190) for the treatment of Katishoola. The selected patient will be subjected to deepana and pachana as purvakarma followed by Vaitarana vasti continuously for 5 days in both group of patients. After giving vasti, paschat karma and pathya-apathya will be followed accordingly. Base line data collection was done before and after treatment and during follow up in both the groups. As per the assessment criteria –Pain, Swelling, Stiffness, Tenderness, Range of movement and X-ray findings, Vaitarana vasti with Gomutra or Dhanyamla both were found to be effective in all the parameters taken for assessment statistically and clinically. According to observations and results obtained it was concluded that the Vaitarana vasti with Gomutra or Dhanyamla both were found to be highly effective in all the parameters taken for assessment of Katishoola.