International Journal of Ayurveda and Pharmaceutical Chemistry

5

Authors: Nashir N Parmar

A 30 year old female patient came to Ayurveda chikitsalay and Panchkarm Centre, Upleta with compliant of bloody diarrhoea, sticky fecal with foul smell, abdominal pain , nausea and burning in chest since 2 years. She was treated with ayurvedic treatments as an outdoor patient for six month period. Āyurvedic preparations like grahankapatras, mustadiyog, and Tablet: Ayopan were given. After 6 months of treatment patient was improving through Āyurvedic management without need of hospitalization and immunosuppressive medicine like Mesalamine1.2gm. All of her complaints like bleeding per ano, sticky fecal with foul smell, abdominal pain, nausea and burning in chest were cured. After six month of ayurvedic treatment Colonoileoscopy report was totally normal.

5

Authors: Devan Reghunathan

Arshasis worldwide public health crisis. Ayurveda offers various measures for the management of arshas. Of these measures bheshaja chikitsa is having more importance. Guda Varti is considered as foremost chikitsa. In this paper its thorough description of properties, preparation and procedure is studied. As varti proyoga are found effective against arshas, their usuage should be fostered in current ayurvedic practise.

6

Authors: Priyanka Rani1 *, Gunjan Sharma2 , Renu Rao3 and Ekta Ramola

Eyeshold special status among all the sense organs because good vision is crucial for social and intellectual development of human beings. Hence authentic classics prescribed several preventive and curative measures for the management of ophthalmic disorders. Among them, topical treatments are very unique, effective in the management of eye diseases and are called Netra Kriyakalpa. Netra Kriyakalpa has very fast action on the target tissues of eye. Anjana is a medicinal preparation which is applied on the lower palpebral conjunctiva. Its active principles may be transferred to the interior of the eye according to their hydrophilic and lipophilic qualities mainly through the conjunctiva and cornea by paracellular and transcellular pathways. Haridradi Anjana is Ayurvedic topical formulation mentioned in Yog Ratnakar1 . The formulation is helpful in curing redness, burning sensation, watering, itching, photophobia, ropy discharge2 in the eye. Keeping all these points in view the present study has been planned with an aim to analyses the physicochemical profile of Haridradi Anjana in ointment form

6

Authors: Aktthu Suresh1 *,Vidya Ballal2 and Anusha

Objective: To study the effect of vishnu taila on endometrium of wistar albino rats Method: In this study,24 healthy wistar albino rats weighing 200-250gms were selected .They were then grouped into four with 6 rats in each group.Group 1 was the normal control group which was given with normal food pellets.Group 2 was the test group which was given with vishnu taila .Group 3 was given with Ovral L. Group 4 was given with Ovral L followed by Vishnu taila after half an hour. The drug was administered orally for 21 days. Animals were sacrificed and histology of uterus was studied. Result: The histopathologic study revealed proliferative phase of the endometrium. Conclusion: From the above study it can be concluded that the drug Vishnu taila can be administered to improve the proliferative phase and thereby facilitating endometrial receptivity for fertilized egg.

7

Authors: Veena Kumari1 *and Niranjan Rao

Kamala is Raktapradoshaja vikara in which there is excessive aggravation of Pitta dosha that burns Rakta and Mamsa dhatu which in turn leads to the manifestation of disease Kamala. It has great resemblance with Jaundice. Liver disease produces a wide range of clinical manifestations. Jaundice is the main manifestation of acute liver disease, usually in association with systemic features of acute illness. Jaundice refers to the yellow appearance of the skin, sclerae and mucous membranes resulting from an increased bilirubin concentration in the body fluids. In our classics we get detailed treatment modalities for the disease Kamala through Shodhana, Shamana and Nidana parivarjana. Here a case of Kamala has been discussed along with its effective management.

8

Authors: Mukesh Kumar Tiwary1 *, Gitanjali Sasmal2 and Vinay Bhardwaj3

Ayurveda is the science of life. Ayurveda has great contribution in treatment of diseases as well as prevention of diseases. If we follow the rules of Dincharya we will be healthy without any medicine. The first step in Dincharya is Brahma Muhurta. Brahma muhurta is a period of two muhurtas, or about one and half hour before dawn. In the Ayurvedic literature, this period is considered as ideal time for Adhyayana, Vyayama, Dhyana, Worship or any other religious practices. Nowadays, we all are suffering from diseases due to change in our lifestyle. At the time of Brahma muhurta the environment is clean & pollution free. Along with the clean air, the pleasant atmosphere, absence of noise, rays of the rising sun are very beneficial to the health. The cheerful atmosphere has a considerable effect on the body and mind. The person who wakes up in Brahma muhurta (early morning), his ageing process is delayed as it decreases oxidative stress in body. Awakening in Brahma-muhurta destroys the harmful effects at primary level as well as increases the health and life span. It is important to understand about the relation of Doshas with the time of the day. After review of this article, aim of this study to know about the physiological benefits of waking up in Brahma Muhurta.

8

Authors: Renu Bharat Rathi and Bharat Jagdish Rathi

Corona virus is initiating cluster of severe acute respiratory syndrome all over the globe, leads to pandemic. The major preventive mode is being self-isolated if symptoms present and remain in quarantine if asymptomatic but exists history of contact or travel. According to Ayurveda, no disease can occur if Doshas are in balance and Agni is in good state, in turn immunity also persists optimum to defy any disease. Therefore, for prevention of any Nija-AgantujSansargaj/Upasargaj Vyadhi /communicable disease, one should follow daily-diet-seasonal regimen-cleansing by Panchkarma, Sadvritta (Code of conduct), Acharrasayan-AR(ethical principles), Satvavajay (mind control therapy) and Rasayanadi few Ayurveda interventions which may prove helpful in prevention and management of new viral infections prevalent now a day.

8

Authors: Preeti1 *, Sanjay Kumar Singh2 and Seema Joshi

Nadi Pariksha is one of the important parameter mentioned under Ashtvidha Rog Pariksha by Yogratnakar. He has given so much importance to this Pariksha that he placed Nadi at the topmost position under Ashtvidha Pariksha. One can determine the healthy and diseased state of the individuals as well as normalcy or disequilibrium of Dosha, Dhatu,, Mala and Agni is assessed through the behaviour of different types of Pulses. The Concept of Nadi Pariksha found in various ancient Ayurvedic Samhitas like Sharangdhar, Bhavprakash, Yogratnakar Ravansamhita, Kanad etc. Acharya Sharangdhara flourished it in his work as a means of diagnosis and prognosis. The aim of this work is better understanding of the different characters of Pulse mentioned in Ayurvedic literatures in modern perspective.

9

Authors: Santra Ramen1 *, NR NavodayRaju2 , PR Rajalekshmy3 and Panchaxarimath Archana

Tea and coffee are the popular beverages consumed worldwide. Yearly an average of billion kilograms of tea and coffee are produced and consumed. Caffeine-containing beverage is most common drink next to water. Although caffeine may improves airway function modestly up to four hours in people with asthma. But more consumption of tea and coffee has some ill effects on different system of the body. Other than consumption of tea or coffee, the adulteration which are admixtures causing severe health hazards. To maintain a healthy lifestyle one should follow the health beverages mentioned in Ayurveda according to season. Traditional health drinks are to be promoted and bring in to practice instead of tea and coffee, which is beneficial for health.

9

Authors: Sapna Kumari Vishwas1 *, Anil Kumar2 , K K Sharma3 , SanjayGupta4 and Parul Sharma

Nasya Karma is one among five procedures of Panchakarma, in which processed medicines is delivered through nasal route, either in the form of Ghee, oil, powder, liquid or smoke. It is particularly indicated in the treatment of Urdhavajatrugata Rogas(diseases occurring in the organs situated in Shira Pradesha/above the clavicle) but it works on the diseases of whole body by improving the activity of the different glands and nervous system. According to Ayurvedic classics Nasa is the entrance (doorway) of Shira Pradesha which means that it might be connected pharmacodynamically through neurovascular system i.e.blood vessels &nervous system (olfactory nerves). The Nasya Dravya which is administered in nostrils reaches to the Shira and eliminates the vitiated Doshas, which are responsible for producing disorders. Pharmacodynamics of the Nasya Karma can be understood through various mechanisms related to anatomical and physiological studies i.e. absorption mechanism, vascular pathway, lymphatic pathway & neural pathway

10

Authors: Ruksar1 *, Anamika Soni2 and Suredra Soni

Aging itself is not a disease however, the risk factors of developing diseases increases with age. The population of the elderly in India was 57 million as compared with 20 million in 1951, as per the 1991 census. There has been a sudden and progressive increase in the number of elderly persons between 1991 and 2001 and it has been projected that, the number of elderly people would rise to about 324 million, by the year 2050. The diseases occurring due to aging in elderly are known as Geriatric disease. Risk factors for geriatric diseases are trauma/injury, development of non-communicable diseases, poverty and social isolation. Common geriatric diseases are Dementia, Mental disorders, Sleep disorders, Osteoporosis, Osteoarthritis, Heart disease, Alzheimer’s disease, cognitive impairment, impaired mobility, Chronic pain disorders etc. According to Ayurveda, ageing (Jara) is considered as Swabhavaj Roga. This principle of prevention involves following the Ayurvedic daily regimens (Dincharya) eg. Anjana, Abhyanga, Nasya etc., Seasonal regimens (Ritucharya) and proper dietary protocols which are main elements for prevention of Geriatric disorders. The role of Rasayan drugs in prevention and treating geriatric problems is also well proved in various clinical studies.

11

Authors: A Clinical Study on Assessment of Psychological Stress and Sleeping Quality in Patients of Pandu Roga Vis-A -Vis Iron Deficiency Anemia (IDA)

Introduction – Iron deficiency is very common cause of anemia in the world and is more dominant in women than men. Iron deficiency anemia (IDA) is considered as a nutritional deficiency disorder. Ayurveda has also given description about a similar disease Pandu Roga (a disease entity with clinical picture resembling anemia) in Charak Samhita, Pandu Roga Adhyaya wherein the disease has been described to be caused also due mental or psychological stress. Sleep is reported to be affected negatively by psychological stress. Further, a research paper on sleep quality in IDA patients, also reported for bad sleep quality in them as compared to controls. Based on the above concept of Ayurveda and contemporary medical science, the following paper aims to assess the psychological stress status and sleeping quality in the patients of IDA (comes under the umbrella of Pandu Roga) as compared to healthy controls. Material and Methods - 30 newly diagnosed cases of IDA (Pandu Roga) from the OPD and IPD of the institution were assessed for stress by Perceived stress scale (PSS) and sleeping quality by Pittsburg sleeping quality assessment index (PSQI) and compared to 30 healthy controls to observe for any relationship. The data was analysed statistically using IBM SPSS version 16.0 (Illnosis,USA.) and GraphPad Prism 5 (GraphPad Software Inc, CA, USA). Statistical significance was considered among the groups (p<0.05). Observation & Discussion - It was found that 56% of patients and 30.5% controls reported a bad sleep quality. The total Pittsburgh sleep quality index score was 6.56±0.32 in patients and 6.23±0.23 in controls as revealed by PSQI. Assessment of stress status by PSS revealed severe PSS with value 24-30 found in 6 cases as compared to 3 controls and moderate PSS of 14-23 was found in 20 cases as compared to 19 controls. The total Mean perceived stress score in cases was observed 20.10±0.60 and 19.20±0.94 in controls. No statistically significant correlation was observed between PSS and Hb values in controls and PSS and sleeping quality in both cases and controls. Conclusion – The study reveals some scientific evidence to the etiopathological part of psychological factors Chinta (stress), Shoka (grief), Krodha (anger or frustation) and Bhaya (fear) in the causation of Pandu Roga (IDA). There seems to be cause and effect relationship between stress and IDA. Sleeping quality was found deteriorated in the cases as compared to controls. However, the study revealed no association between stress and sleep quality

11

Authors: Nibedita Panda1 *, Tarun Kumar Dwibedi2 , Manjunath Akki3 and Suresh N Hakkandi

Ayurveda is the science of life. It heals by using the natural resources. Janu Sandhi is the largest joint and bears the weight of the body. Janusandhigatavata is one of the most painful conditions of human body. It worsens the daily life. Its prevalence rate is 5.78% in rural India, among them 25-30% are symptomatic and 80% patients are at the age of 65 years. The Pain and involvement Janu Sandhi indicates the vitiation of Vayu. Ushna, Snigdha, Vedana Sthapana are the characters that reduces Vata Dosha. Hence, it will also reduce the signs and symptoms of Janusandhigatavata. Bhaishajya Ratnavali advocated the use of Vishagarbha Taila in Vatavyadhi Rogadhikara. It has the same properties that are required to pacify Vata Dosha and its symptoms. The Vishagarbha Taila can be used in the form of Abhyanga and Dhara. However, we have modified Janubasti based on the concept of Shirodhara, ShiroBasti, which are explained in the context of Mrudhni Taila by Acharya Vagbhata and Netra Tarpana explained by all the Acharya of Brihatrayee and Laghutrayee. The luke warm oil is poured to the prepared Janupaali and this oil is kept for 30 minutes. The Swedana as Poorvakarma and warmth of the Taila causes vasodilatation and modulate the absorption of the active principles presents in the Vishagarbha Taila. This absorption is favored by the bilipid layer of cell membrane to enter the active principles of the Taila to the cell organelles and nourishes them. Thus restoring the normal function of the Janu Sandhi, i.e. movement and relives pain of the joint.

12

Authors: Deepak Verma1 * and Shivangi Kunwar

Arsha is one of the commonest disease which affect people now a days. It is correlated with the hemorrhoids due to similarities in the appearance of the masses. According to Acharaya Charaka the treatment of the Arsha is given after the assessment of the Dhoshika predominance. To evaluate the dominant Dosha Acharayas have describe clinical features of different Doshika Arsha. Formation of Mamsa Ankura is one classical feature of Arsha. Mamsa Ankuras are the masses occur in the Guda region and have different shape, colour or appearance. In present time these Mamsa Ankura are correlated with the Hemorrhoidal mass due to their resemblance, therefore it is diagnosed and treated as Hemorrhoidal mass by the medical practitioners. The aim of this research is to clarify the features of different Doshika Arsha Mamsa Ankura described in Sushruta Samhita and then evaluate that either these features are present in the Hemorrhoidal pile mass or not. Clarifying the features of Mamsa Ankura and also its relation with the hemorrhoid pile mass is the main purpose of this research.

13

Authors: Gopa Kumar1 *and Santhi Krishna A S2

BACKGROUND: In Ayurveda Classics, Sneha Kalpanas constitutes to be the most widely used and preferred formulations as it incorporates both water and lipid soluble active constituents of the medicine adding to its therapeutic efficacy. Vachalasunadi Taila (VT) is a potent poly herbal formulation explained in the context of Ear Diseases in Sahasrayogam. No research work has been carried out till date and hence an attempt is made to evaluate the Pharmaceutico -analytical standardization of VT with special reference to Murchita (MTT) and Amurchitha tila taila (ATT). METHODOLOGY: VT was prepared as per the reference of Sharangadhara Samhita. The sample was subjected to different phytochemical parameters like pharmacognostical, physicochemical, and instrumental method of analysis comparing Murchitha (MTT) and Amurchitha (ATT) Tila Taila. RESULT: Results for parameters includes specific gravity (0.89, 0.91 gm/ml), Refractive Index (1.486, 1.495), acid value (0.44, 0.45), iodine value (111.81, 113.67%), saponification value (187.09, 190.65), ester value (186.65, 190.2). Instrumental analysis with HPTLC and GC-MS for MTT and ATT also showed a slight difference. CONCLUSION The Pharmaceutico-Analytical standardization of samples reveals an improved stability data in terms of longer shelf life for VT prepared with MTT and VTA showed significant results in all other assessed organoleptic and physico chemical parameters.

13

Authors: Borkar Sneha P1 *, Dalvi Prachi D2 and Mahesh Deshpande

Physical and mental constitution plays a vital role to form a sportsperson. Sports and Exercise are essential part of human life. It helps in development of an individual at physical, mental, social, cultural and spiritual level. Neck and shoulder joints are primarily used in all activities. Along with the daily exercise, help of Ayurveda in training of sportsmen can give lucrative results. Nasya is one of the effective ways to improve the musculature of the neck, shoulder and chest. This study is randomized controlled clinical trial. The study was carried out in 2 groups, of only 100 male regular healthy athletes. Aim: To assess the effectiveness of Anutaila Nasya on muscular strength of shoulder and chest in Athletes. Methodology: Sample size: 100 Athletes were selected .GROUPING: 1. Experimental group: This Group received Anutaila Nasya along with their regular exercise for 3 months daily. 2. Control group: This Group was kept only on exercise without Nasya for 3 months. Agegroup: between 20– 30 year. Results Chest and shoulder muscular strength increases by doing nasya therapy along with exercise after 90 days.

14

Authors: Pawan Kumar Sagar1 *, R Murugeswaran2 , R.P. Meena3 , M.W.Ahmed4 , S.A.Ansari5 , S. Khair6 , and S A A Hashmi7

Standardization is used to describe all measures under taken during the manufacturing process and quality control as well as quality assurance of drug leading to its reproducible quality. Most of the traditional and classical preparation of compound medicine are effective but still they lack in its standardization. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Itrifal Haamaan is therapeutically used as Blood purifier, Anti-Vitiligo, Anti-Pityriasis, Prevents premature graying of hairs and Phlegmatic diseases. The drug Itrifal Haamaan was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-IV). Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprinting, quality control and assurance parameters using WHO guidelines to ascertain the quality of drug. The physico-chemical data showed that the drug contain LOD/ Moisture (9.51%), Total Ash (1.65%), Acid in-soluble Ash(0.60%), Alcohol and Water soluble extractive matters (51.07%) & (71.04%), pH(1% solution) (4.77), pH(10% solution) (4.26), Bulk Density (1.5415 gm/ml),Reducing Sugar and Non-Reducing Sugar (58.54%) & (7.79%) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent).The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, and can be considered safe for internal use and for curing for treated patients. The evaluated standards will be very useful for laying the phamacopoeial standards and as be supporting reference of Itrifal Haamaan and also in providing the quality medicine to needful human being.