International Journal of Ayurveda and Pharmaceutical Chemistry

5

Authors: Manisha R. Dehankar and Sunil G.Topre

Ayurveda is the most ancient medical science of the world. The main purpose of ayurved is to maintain the health of healthy individual and cure the disease of diseased one. Rasayana Tantra is one among the eight major division of Astang ayurved. Rasayan chikitsa helps in maintaining the healthy life style. Ayuved has describe various types of Rasayana which can provide protection against diseases,promotes physical health,improve the status of dhatus, can confer immunity & rejuvenate the system.The purpose of the rasayana is to obtain strength,immunity,oja,vitality,will power & determination and it also strengthen the senses. According to ayurveda oja is an essence present in every dhatu & considered as sara of all saptadhatus and responsible for strength of the body. Many herbs & dietery materials can act as rasayan & work as immune stimulant,anti-stress agent etc.one of the result of rasayana is it promotes oja in the body which is the factor responsible for vyadhikshamatva (immunity) so that person will not suffered from any diseases. Purpose of this paper is to discuss about the role of rasayana in enhancement of qualities of oja.

6

Authors: Mahreen Fatema Ayaz Ahmed and Sunil.G.Topre.

Today’s lifestyle pattern will leads to several metabolic disorders. Sidhant of ‘Hetu’ and ‘Nidan’ mentioned in our Samhitas exactly matches with whatever is going on in ‘Modern Lifestyle’ pattern. As mentioned by Vagbhata, Nidan of all diseases is imbalanced Doshas, and the reason behind this imbalance in Doshas is ahitkaraahar-vihar. Aacharya Charaka has mentioned that GramyaAahara as a mula of Sharirik Rogas. In modern science, diabetes occours due to faulty insulin production and uptake. If we go through Ayurvedic texts Prameh Roga is very similar to Diabetes. Prameha Roga comes under Ashtomahagada. Unique feature of Prameha is the involvement of tridoshas and multiple dhatus, ojas etc. While reading to Ayurvedic literature of hetus of Prameh Roga we comes to know that, these hetus can be further divided into Aahariyahetu, Vihariyahetu and Manasikhetu and where these hetus come in day to day life. This paper is designed to show the hetus mentioned in Ayurvedictext and where it comes under today’s lifestyle. By avoiding these hetus one can prevent Diabetes.

6

Authors: SandeepGorakhMane and Bhavana S.Mane

Man has eventually forgotten the absolute enjoyment and solitary affection for nature, and as a result he is facing many health problems. The prime factors that are responsible for the decline of health are irregular food habits, stress, suppression of natural urges, lack of proper sleep and relaxation. Sciatica pain is often caused by pressure on the sciatic nerve from a herniated disc, bone spurs or muscle spasm. Sciatica being considered as a chronic disease needs a long lasting treatment with non-steroidal anti-inflammatory drugs, muscle relaxant and analgesics. The symptoms similarity and radiation of pain from back to the foot describe the correlation of sciatica with Gridrasi. Here a case study was done on a patient with right leg acute sciatica symptoms from 3 months treated successfully with ayurvedic intervention for 2 months.

6

Authors: Ramesh Madhavrao Bansode and Archana U Kalyankar

Ayurveda is essentially the science of life. Ayurveda has scientific background and will provide stimulus to new and original renovation from the remodelling of theories and concept. One of the basic fundamental concept or view of Ayurveda is Ojas.Oja is the essence of dhatus, which gives strength to the body, improves immunity power and takes care of well being of the body.Ojas means “vigorand in ayurvedic literature, Bala, Prakriti and Kapha these types of words are used as synonym of Ojas. It is present throughout the body like, ghee exists in the milk or honey exists in the flower.Ojas is responsible for consciousness, purity in thoughts, health, and positivity in feelings in every situation, better immunity, longevity, intelligence and memory. So according to ayurveda oja is one of the most important elements for maintains and sustenance of life. All human beings are well nourished by Ojas and its decrease leads to the cessations of life. It controls and regulates the whole working system of the body, so it has more clinical importance. It provides strength in the form of physical, mental, immunological and resistance to the body. Due to stress, depression and other etiological factors, ojas gets affected. And it leads to the condition of ojakshaya , It is difficult to define Ojas as per modern methodology.This review article attempts to create certainty of Ojas understandable in scientific way and itsover all effects on human body which will be helpful for scholars in treatment of diseases and advising precautions.

7

Authors: Sagar Bhut and Sunil Changle

Kashyap Samhita is one of the most ancient compilation of Acharya Kashyapa related to care of the children. Phakka roga is a special contribution of Kashyapa Samhita. The development has been mentioned in this context. The prenatal, natal, postnatal, socioeconomic and environmental factors affecting growth and development of child.Etiology of the disease, itself is selfexplanatory and describing its type i.e., ksheeraja, garbhaja and vyadhija phakka. Qualitative and quantitative deficiency of required micro and macro nutrients affects the overall growth and development. Not even in neonatal period but also in-utero embryonic environment and fetal nourishment status determines the outcome after birth. The milk fed by mother is primary source of nourishment. Mother's milk if deficient in quantity and quality is responsible for impaired and delayed growth of child's physical and mental faculties. Neonatal insult exposure like chronic diseases i.e., recurrent gastrointestinal and respiratory infection, worm infestation, bleeding disorder, endocrine and metabolic disease decelerates the process of growth and overall wellbeing of a child. Socioeconomic and environmental factors contribute and play a vital role. Socially and economically sound family can bring up a child in a proper way whereas stressful social environment and poverty negatively affects the growth and developmental processes

7

Authors: Vikrant Thakur and Kunj Biharee Saini

Srotas are the channels of circulation or dynamic inner transport system of the body which provide platform for activities of other important bio-factors like three Dosh, Dhatu, Oja, Agni etc. The word Srotas is originated from the main Sanskrit root “Sru Srawane’’ meaning the structure to flow, to exudates, to filter, to ooze and permeate. Each Srotas is attached to a specific anatomical structure called Moola. The normal functioning of Srotas depends on Moolstana. Rakta is considered as Jeevan in Ayurveda texts. Raktavaha Srotas are channels of circulation concerned with the blood formation, storage and circulation of blood and lymph in body. Yakrita, Pliha and Raktavahi dhamnis are considered as moolsthana of Raktavaha srotas by Acharyas. Yakrita can be correlated with Liver. Most of the blood related concepts like haemopoesis, storage and decomposition of red blood cells are rooted in liver. Microscopically, liver is made up of minute channels of circulation or vessels which help in normal functioning of Liver.

7

Authors: Payal P. Suryawanshi and G. H. Kodwani

Nerve and muscle problems cause muscles to react in abnormal ways. During leg pain or numbness tests are carried out to know how much nerves are affected, how well nerves in arms and legs are working. Nerve conduction (NC) study is done to find the above damage to peripheral nervous system. An electromyogram measures electrical activity of muscle at rest and during contraction Impulses make the muscles react in specific ways. NC studies measure how well and how fast the nerves can send electrical signals. Nerves control muscles in the body with electrical signals called impulses. These tests are often used to find nerve problems such as Guillain-Barre Syndrome (GBS). GBS is a rare but serious autoimmune disorder in which the immune system attacks healthy nerve cells in peripheral nervous system. In Ayurved Lakshanas of Vata vyadhi – Sarvangaghat such as weakness, numbness, tingling sensation can be correlate with GBS.

7

Authors: Roshni Dhurve

Disk-related complaints, particularly Low back pain are very common. Once in a life time all of us suffer from symptoms related to degenerative changes of the intervertebral disc disease. Back pain is second only to the common cold as the most frequent reason for visiting a physician and is the most common chronic pain syndrome in industrialized countries. It is mostly a self limited illness. As per the report of WHO, Low back pain (LBP) constituted 37% of all occupational risk factors which occupies first rank among the disease complications caused by work. The lifetime prevalence of non-specific (common) low back pain is estimated at 60% to 70% in industrialized countries (one-year prevalence 15% to 45% , adult incidence 5% per year). Prevalence increases and peaks between the ages of 35 and 55 years. The present article deals with a case diagnosed as Lumbar Disk Disease with Spondylolisthesis of L5 over S1 and was advised for surgery. The Ayurvedic diagnosis was made Kati graha on the basis of their symptoms harmonizing with the disease. Oswestry disability index (ODI) score and Verbal rating scale (VRS) was adopted for pain before and after the treatment. Before treatment, Patient was wheel chair dependent and not able to walk even 4-5 steps due to severe pain. After treatment, patient showed improvement of 37.77 % on Oswestry disabilitly index and 40% on Verbal rating scale. Acharya Sushruta stated that Siravedha is accepted as half of the therapeutic measures in Shalya tantra like Basti in Kayachikitsa and a superior therapeutic procedure among others as it gives instant relief.

7

Authors: Gunjan Sharma, VandanaSrivastava, P.K Singh, Parinita Fulera and Lotika Bharti

Ayurveda is a treasure of herbs that are being used in both preventive and curative aspect of life. Ayurveda is rich in various already prepared formulations mentioned by our Acharyas that need to be explored. There is need of making these formulation patent and standardization. All these formulations demand scientific study and standardization. One of such formulation is Darvyadi Raskriya mentioned in our classics in context of Sharangdhar Samhita (Netraroganashak Upchaar). Materials and method: To standardize the sample on physiochemical parameter, it was tested in analytical laboratory and results were documented. Result: The result shows the organoleptic character, sterility and clarity. Conclusion: Darvyadi Raskriya was prepared by following the method prescribed in Sharangdhar Samhita. Pharmaceutical and analytical profile of Darvyadi Raskriya was established on the basis of microscopic features, TLC fingerprint profiles and the physiochemical parameters.

8

Authors: Nitin Chandurkar and Shweta Mali

The experience of motherhood is most unique as well as challenging phase in life of every woman. For a woman, the birth of baby can boost a jumble of powerful emotions from happiness, excitement and exhilarating to sadness, fear and exhausting. During this phase of her journey, she is in need of proper care, support and guidance in order to cope-up with her new identity of motherhood. But due to fast changing life style of modern era and increase in isolated families, she is deprived of this necessary attention during her crucial postpartum time. So, in the absence of adequate rest, balanced nutrition and moral support sometimes, a mother can be harsh in a way that she has never dreamed off by developing signs and symptoms of postpartum depression. It can shatter her body, mind and spirit. In today’s date, one out of every eight woman is prone to postpartum depression. The Ayurvedic science is holistic approach to physical and mental health care of mother and baby. The principles stated in the classics not only manage postpartum depression but also it does not allow a woman to land-up in this phase.

8

Authors: Nandesh Mohan P., Shashirekha K.S. and Maithri H.D.

Plectranthus amboinicus has been reported to be traditionally used for medicine to cure common illnesses such as cough, stomachache, headache and skin infection. The present study is focused mainly on the ability of aqueous and ethanol extracts of the leaves of a traditional Indian medicinal plant against the pathogenic bacteria showing resistance against Ampicillin and Fluoroquinolones, isolated from respiratory infections. Different concentrations (20, 10, 5, 2.5, 1.25 μg/ml) of aqueous and alcoholic extracts were tested by agar well diffusion method. It was observed that the both extract were significantly inhibited respiratory resistant pathogenic bacteria against Ampicillin (10µg). The present study is therefore successful in indicating that Plectranthus amboinicus is useful in treatment of respiratory disorders associated with bacteria.

8

Authors: Gunjan Keshri and Anil Chaudhary

Wound is a break in the integrity of the skin or tissues due to external violence or some mechanical agency. Wound healing occurs with the help of granulation tissue and epithelization. Hypergranulation tissue is excessive granulation tissue that hinders the normal healing process by preventing re-epithilization and wound contraction Acharya Sushruta mentioned Avasadna dravya for such conditions of vrana, which include both herbal and mineral drugs. These are Kasish, Hartala, Manhshila, Manikya, Chameli pushpa, Shirish and Karanj fruit, Saindhav, Kinva, Kukkutanda kapala. Kasishadi churna is a combination of herbo-mineral drugs which are having properties of Lekhan, Shodhana, and Ropana properties. It is a procedure of debridement of wound.

8

Authors: Kothainayagi and Premraj Chaudhary

Ayurvedic medicine is a medical specialty that focuses primarily on preventive and curative medicine. It is a system of healing that is based on being in accordance with the laws of nature and has its origins in India around 5000 years earlier. Ayurveda offers guidelines to be followed daily right from the time of waking up in the morning till going to bed at night in terms of brushing, bathing, sleeping habits, exercise, massage and so on. Though we are following a routine daily regimen and seasonal regimen, we unknowingly do some mistakes. And this is where Ayurveda helps us and brings us back to track. As there is increase of oral disease even at an early age and becoming a greater concern, here in this article the maintenance of oral health is dealt with. Simple modifications in our habits can help us enjoy our lives much better.

9

Authors: Sarita Gaikwad

Snakebite is very common problem encountered in India. Apart from mortality, the morbidity is also high. Treatment of complicated wounds resulting from cytotoxic snake poison poses multiple challenges. Snake bite wounds are complicated, that take longer time to heal, leaving some disability to the subjects. Here is the case study of snakebite infected wound that was failed to heal by modern therapy. There was one stage when amputation of the limb was seemed very eminent, when Surgery department referred the case to Ayurved department for further management. Ayurved department successfully managed the case in spite of developing complication of Osteomyelitis with sinus formation. This case study highlights the strength of Ayurvedic principles that could be applied for treating such type of wounds. Therefore a multidisciplinary approach is required to treat snakebite cases, the modern therapy is definitely superior in treating the emergency, but Ayurved is better alternative for treating complications of snakebite like extensive infected wound.

9

Authors: Ramesh M. Bansode1 , S. S. Sant2 , J.J. Pawar3 and Vinaya Potdar

Ayurveda has described fundamental concept of Tridosha, Dhatu and Mala. Knowledge of these fundamental concepts have much more significance in understanding the etiopathogenesis, sign and symptoms, prognosis and management of Prameha. It is characterised by excess, frequent sweet micturation, burning sensation of palm of hand and leg, Sheeta priyata (desire to cold), sweet taste in mouth, excessive sweating, body odour etc. Any diseases in the body do not exist without Tridosha. In Prameha all three Doshas and all Dhatus except Asthi Dhatu get involved. Mala like Sweda and Mutra get vitiated. Tridosha get vitiated in Prameha especially Kapha have major part. It affects other Dosha and Dhatu along with their Srotasa . Dosh-dushyaSammurchana results manifestation of Poorvaroopa (premonitory) & Roopa (symptoms). These are associated with the symptoms of vitiated Dosha and Dhatu in Prameha . Tridosha have Ashrayashrayi-Sambadha (mutual relationship) with Rasadi Sapta Dhatu in the body. So it manifests associated symptoms as per their involvement and predominance of Dosha Dhatu in Prameha. So it is important to study the play role of Dosha, Dhatu and Mala in Prameha to understand etiopathogenesis , signs and symptoms.

10

Authors: Ranjitha B.M.

Background: Shweta pradara is a common gynaecological complaint faced by the women of all ages, because of moist and sweaty genitals. Shweta pradara is one of the most common of all where women approach to hospital. A woman reaches various stages in her life which includes puberty, reproductivity, pregnancy, labour, puerperium, menopause etc. During all these stages, there will be many physiological changes one of which is secretion in vagina termed as leucorrhoea or shwetha pradara. Objectives: 1. To evaluate the effect of Lodhra and Vata twak kwatha in Shweta Pradara Method: Married females between the age group of 20-40 years with complaints of excessive discharge per vagina and vaginal smear negative for organisms were taken for the study. Lodhra kalka with vata twak kwatha was given for 45 days and assessment was done on every 15th day of the study. Result: Most of the parameters showed significant results at p value <0.001. Overall effect of therapy showed that 50% had complete remission, 23% had moderate improvement, 7% had mild improvement, 3% had no change, 16% got marked relief. Interpretation & Conclusion: Shweta pradara develops due to vitiation of kapha and vata. Based on the result, it was found that Lodhra due to its sangrahi and kandughna property and Vata due to its shoshana property combated shweta pradara.

10

Authors: Adiga Shripathi H, Malagi KJ, Adiga Ramya S, Hebbar Krishna Raghava and Nayak V Anupama

Ayurveda, appropriately addressed as the ‘science of life’ accurately answers many arduous health issues and aids human beings to lead a healthy and a happy life. Complete rectal prolapse, apprehended and acknowledged as ‘Guda bhramsha’ in the classics of Ayurveda is an exemplification of the same. This noteworthy case study of complete rectal prolapse in an elderly patient, treated in accordance with the classical line of management with Snehana, Swedana, Anuvasana with the incorporation of Mushika taila, a special oil prepared with Anthravarjitha Mushika mamsa emerges as an example of the authenticity of this great science. Complete reversal of the symptoms, even though for a brief period of time, establishes the realisms of classics and demands further apprehension and analysis.

10

Authors: Ashish Mishra, Amit Mukherjee, and Mukund Supekar

Nasya (Nasya Karma) is a term to be applied generally for medicines administered through the nasal route. The formulations used for the purpose of Nasya Karma are called Nasika Kalpana. Since nose is the gateway of the head, the therapy is highly effective in curing a number of diseases pertaining to the head, if it is performed systematically. The therapy cleanses and opens the channels of the head, thereby improving the process of oxygenation (prana), which has a direct influence on the functioning of brain. The therapy is beneficial if done on a regular basis, because it keeps the eyes, nose and ear healthy. It also prevents the early graying of hair. Nasya karma is mainly indicated in the diseases of head and it can be done in many other conditions which effects the head as head is the important part of the central nervous system that regulates functions throughout the body.

11

Authors: Ajantha, Anoma Geethani Samarawickrama, Chethana Kumari DS and Anjana

Grahaniroga is a disease caused due to faulty life style which includes faulty dietary habits, regimen and psychological factors. Aharaja nidana include Pramitasana (intake of food in less quantity or eka rasa sathmya), Vishamasana (irregular food habits), Adhyashana (intake of food before pervious meals get digested), Samashana (intake of compatible and incompatible food together), Viruddhashana (incompatible food) and not following aharavidhi. Viharaja nidana(faulty regimen) are Diva Svapana (Day sleep), RatriJagarana (remaining awake at night) and Vega Vidharana (Suppression of natural urges).Manasika nidana are Chinta (worries), Shoka (grief), Bhaya (fear) etc. These factors affect agni and later grahani vyapara leading grahaniroga. A better and complete understanding of the disease is possible by analyzing nidanapanchaka which aids in diagnosis, prognosis and management. In this article, an attempt is made to compile, review and discuss nidanapanchaka of grahaniroga in a systematic way.

12

Authors: BhatambreYogesh and Bhange Pallavi

Standardization of Ayurvedic drugs is an important and essential measurement for the quality control of drugs. It is necessary to provide drugs having good quality. While preparation of drug, standardization of raw material, standardization of the process i.e., in-process standardization and that of the final drug is necessary. Among these, in-process standardization carries more importance. It includes selection of the reference of the formulation, selection of the instrument to be used, development of Standard Operating Procedure (SOP) of the manufacturing of the drug, various tests to be carried out during the procedure, etc. A critical review has been done in present study regarding the needs and challenges in the in-process standardization.

12

Authors: Mayur Temburne and Mrunal Tiwari

Ekkushta is a type of Kshudrakushtha described in Ayurveda . It is a Vata-kaphaj disorder. The clinical symptoms of Ekkushta described in Ayurveda resembles with the clinical symptoms of Psoriasis. The clinical features of Ekkushta described by Charak and Kashyap represent remission, relapse and seasonal variation which are present in Psoriasis. It is one of the common dermatological problems in the world.Aragwadha is basically kushthaghna and vishaghna. This agad was administered orally to treat Ekkushtha. This study was an attempt to assist the medical fraternity in tackling the situation by the optimum utilization of kushthghna and vishaghna karma of AmaltasKwatha.

13

Authors: Vrinda, Shobha G Hiremath and Surekha S Medikeri

Bhasmeekarana of metals and minerals is a unique technique in Rasashastra. In order to obtain a safe and effective Bhasma, a good quality raw material and specific preparation procedure plays a vital role. Standard operative procedure with respect to procedure of Bhasmeekarana of Lauha is already set, but a standard to select raw material (Iron) is not yet established. Discarded Iron is usually selected to prepare Lauha bhasma but its details like chemical composition; percentage of other impurities etc is unknown. Hence a study was taken up to clear this obscurity and ensure a desired quality of Lauha bhasma by selecting two types of Iron with definite composition viz., Cast iron identical to Munda lauha and Wrought iron identical to Teekshna lauha. They were subjected to Bhasmeekaranaas per the reference of Rasendra saara sangraha and physico-chemical analysis and instrumental validations like XRD, FTIR, SEMEDAX were then carried out. Both the Bhasmas obtained were appraised based on pharmaceutical and analytical grounds. Munda lauha attained Bhasma siddhi lakshanas faster than Teekshna lauha but the latter was found to be of superior quality by inferring the results of analytical study.

14

Authors: Shikha, Renu Rao, Gunjan Sharma, Priyanka Rani and Mohan Kumar

Seka Karma is a Kriya Kalpa procedure, in which instillation of medicated Kwatha is done on closed and relaxed eyes for a fixed time period. It is done in inflammatory (Amavastha) conditions of Vartma (eye lids). Acharya Sushruta has described Praklinna Vartma under 21 Vartmagata Rogas. It is a disease of Vartma caused by Kapha Dosha. On reviewing the clinical presentation it can be correlated with blepharitis. Itching, accumulation of white dandruff like scales on lid margin, persistent soreness of the eyelids or eyes, greasy appearance of the lid margins, falling of eye lashes etc. are the main clinical features of blepharitis. Modern science treatments of blepharitis mainly aim at topical antibiotic ointment like Sodium fuscidic acid, Bacitracin, Chloramphenicol, Kenalog etc. along with topical weak steroid ointment like Flurometholone which usually provides symptomatic relief. Hence this study was designed to collect, evaluate and discuss about the mode of action of Seka Karma in the disease Praklinna Vartma (Blepharitis). The desired effect of Seka Karma was achieved by using Seka Yoga having Haritaki, Vibhitaki and Amlaki means Triphala having Tridosha Shamaka qualities. Aims & Objectives1. To evaluate the efficacy of ‘Seka Yoga’ in the management Praklinna Vartma (Blepharitis). 2. To assess the efficacy of ‘Seka Karma’ in the management of Praklinna Vartma (Blepharitis). Materials & Methods -Fifteen clinically diagnosed patients of Praklinna Vartma (Blepharitis) were randomly selected from OPD/IPD of Rishikul Campus, Haridwar. Seka Karm was performed for fifteen days continuously. Results- 46.7% patients showed marked improvement, 46.7% patients showed moderate improvement and 6.7% patients showed mild improvement

15

Authors: Sarita Gaikwad

Anemia remains a major challenge in treating cases of Chronic Kidney Disease (CKD), as the pathology is still not fully understood. Anemia in CKD is associated with reduced quality of life, increased risk of cardiovascular disease leading to poor outcomes. An open non- randomized clinical trial was conducted on 50 diagnosed Chronic Renal Failure patients. On the basis of CKD-EPI equation,39/50 (78%) study subjects having CKD stage 5, 9 (18%) study subjects having CKD stage 4 & 2 (4%) study subjects with CKD stage 3B. There were 47 study subjects (94%) having anemia, out of which 41were having moderate to severe anemia before start of treatment. At the end of study period, there was significant improvement in their status as only 15 remained with moderate anemia& none with severe anemia.Hb % was estimated at 0,28,84,140 & 180 days. The mean Hb% was 8.39 g ±2.10 g on zero day. On 180thday, mean Hb was 11.07g ±1.67.This31.94% rise in Hb % was found to be statistically highly significant(t= 19.50 with p <0.001).Pallor, Oedema, Fatigue, Weakness, Dyspnoeawere the signs and symptoms considered to be associated with anemia and improvement was assessed in reduction of severity. There was statistically significant clinical improvement in respect of signs & symptoms of anemia. This study proved that the Ayurvedic treatment is a suitable alternative treatment of anemia in CKD to modern controversial treatment of parenteral iron therapy &Erythropoietin supplementation.

29

Authors: Pandey Krishna Kant, Tripathi Arun Kumar and Srivastava Alok Kumar

Mukhadūṣikā, having a symptomatic correlation with Acne vulgaris, is one of the most challenging and stubborn skin disorder prevailing since Vaidika era. It affects approximately 80% of the adolescents around the world. Acne Vulgaris is a polymorphic chronic inflammatory disease of pilo-sebaceous units characterized by comedones, papules, pustules, nodules, cysts, abscesses, and even widespread scarring sometimes. Ayurvedic texts have mentioned vitiation of Kapha, Vāta and Rakta responsible for disease. As the disease is having a chronic nature, modern medicines only subsides the disease for short time period along with various side-effects and relapse also occur on withdrawing the medicines. Therefore, to identify an alternative, safer and permanent cure, Jalaukāvacārana and Siddārthakādi Lepa were selected for the present study to see their effect on Mukhadūṣikā. 30 patients selected from the Panchkarma and KayaChikitsa O.P.D. of the Rishikul Campus, UAU, Dehradun were randomly assigned to 2 treatments groups (15 patients in each). Group A patients were treated with Jalaukāvacārana (4 sittings on a 7-day interval) while in Group B patients, Siddārthakādi Lepa was also applied daily along with 4 sittings of Jalaukāvacārana. Total duration of treatment in both groups was of 28 days along with a follow-up period of 30 days. Assessment was done on the basis of subjective parameters i.e. Piḍikā (Acne lesions) grading and associated complaint grading, as well as objective parameters i.e. count of lesions. Both interventions were found to be significantly effective (p<0.05) in reducing Piḍikā grading as well as associated symptoms i.e. Vedanā (Pain), Dāha (Burning), Pāka (Inflammation), Kandū (Itching), Vaivarnyatā (Discolouration) and Snigdhatā (Oiliness). However, additional benefit of lepa was found only Snigdhatā (p<0.05) and Vaivarnyatā (p>0.05). Both the interventions also showed significant result in reducing count of lesions too. Lepa application was additionally beneficial in reducing the number of all types of lesions but the results were statistically significant on comedones and pustules (p<0.05). None of the intervention was able to reduce the no. of scar/Grading of scars significantly. On follow-up after 30 days, 20% in Jalaukāvacārana group while 13.33% in Jalaukāvacārana along with Lepa application group showed relapse in grading of acne.