International Journal of Ayurveda and Pharmaceutical Chemistry

4

Authors: Santosh Bashakar Somatkar and Kalpana S. Wakode

Ayurvedic approach for management of vartmasharkara and to treat symptoms and to prevent recurrence of disease. Vartmasharkara is one of the vartmagat netraroga which is characterized by irritation, Foreign body sensation, discomfort, occasional corneal abrasion. This condition can be correlated to concretions which are degenerative product of leucocytes to produce an epithelial inclusion cyst filled with epithelial cells and keratin debris. This is most common in old age group. Generally does not cause any permanent damage to eye sight. In Ayurveda treatment comprises of Lekhan and then saindhar shalkshna churna pratisaran. In present study Lekhannottar saindhav pratisaran is selected in the form of local therapy saindhav has property of chakshusha and help to avoid recurrence of disease. Hence selected for present study.

5

Authors: Neelam Choudhary

Masi Kalpana is a dosage form in Ayurveda Pharmaceutics where the drug is brought to a carbonized form by the process of employing heat to the dry ingredients of drug. The drugs selected for Masi preparation can be of plant or animal origin. It is used for both internal and external use. Acharya Sushruta described Masi Kalpana with respect to Vrana Chikitsa. In this article, we have prepared the Triphala Masi by using the closed method.

6

Authors: Neelam Choudhary

Rasa Shastra is a special branch in Ayurveda under which the pharmaceutics of metals/minerals is studied. The preparations which are prepared in the form of thin flakes are termed as Parpati and the entire process is termed Parpati Kalpana. The Rasa Parpati is a special and commonly prepared preparation of mercury, unique in the field of RasaShastra. Rasa Parpati preparation is first mentioned in Nagarjuna for Kushta Rogas in 8th century and then Chakradutta described Rasa Parpati for Grahani Roga. It is prepared using different ratios of Parada and Gandhak using mild heat with the necessary precautions. Parpati Kalpa is one of the Rasa Bandha (process of binding mercury) which helps to remove the Chanchalatvam (unable to be stable) and Durgrahatvam (difficult to bind) of Parada (mercury). Parpati Rasayanas are cost effective medicines that have high therapeutic value and less toxicity. In this article, we have prepared the 3 samples of Rasa Parpati with different ratios of Gandhak and study of its organoleptic properties is done.

7

Authors: Sarika Yadav and Om Prakash Dadhich

Ayurveda is the life science with prime goal of promotion of health and prevention of disease in healthy individuals and alleviation of disease in unhealthy. For promotion of health in healthy individuals, Aacharya Charaka has described a quad of chapters which emphasizes on following specific dietary and day regimen to remain healthy and for prevention of diseases. The dietary and day regimen which is healthy for Srotas (channels) and pleasant to mind is called as Pathya or wholesome. Further Aacharya have described Pathya or wholesome for Swastha (healthy) according to Desha (habitat), Ritu (season) and Ok (habit). These days due to rapid modernization and altered lifestyle in the form of dietary habits and day regimen prevalence of diseases with metabolic and functional impairment like Madhumeha, Stholya (obesity), joint disorders is greatly increased. Among joint disorders Vatarakta (gout) is the disease which involves both metabolic and functional impairment.Vatarakta is characterized by pain, stiffness, itching, burning sensation, altered coloration over joint space and especially involves small joints of hands and feet. It is mainly caused by Mithya Ahara Vihar that is irregular or unwholesome diet and regimen in prone individuals. In Ayurveda the first line of treatment for disease is prevention of causative factors. These causative factors are unwholesome for the disease and can aggravate the condition. Hence, it is necessary to understand and avoidance of causative factors or Apathya. The treatment of disease is mainly of three types’ Yuktivyapashrya, Devavyapashraya and Sattvavjaya. Yuktivyapashra Chikitsa mainly depends on medicine and prescribed diet and day regimen. Hence for diseased conditions Aacharya have described Rog Satmya or wholesome diet and day regimen. Here an effort is made to understand Pathya – Apathya in maintenance of health and specific Pathya -Apathya for management of Vatarakta.

7

Authors: Pradip R. Itnar and Preetam P. Itnar

Sound knowledge of Marma sthana (vulnerable points) behind structural component is essential. According to Parinam (Prognosis) and Rachana (Anatomical predominance), Koorpara Marma (vulnerable point at elbow region) is Vaikalyakar (injury to this type of vulnerable point causes disability) and Sandhi Marma (vulnerable point at bony joints), respectively. No injury to Marma is free from adverse effects. It may cause disability or even death. If we desire to apply concept of Marma in Shalya tantra, it is essential to confirm the exact form of structure and importance of Marma Sharir with help of Ayurvedic fundamentals and with its comparison to modern science on the basis of clinical study. Nowadays, road traffic accidents are more common . Traumatic deformities commonly occur at Elbow region which is exposed easily to trauma, causing restricted movements of forearm along with, hematoma, ligament tear and bony deformity. Hence, a conceptual and subclinical study was carried out to evaluate Koorpara Marma Viddhata in relation to accidental trauma from structural aspect with help of case record form and radiological investigations in 30 diagnosed patients of Koorpara Sandhi Marma Vikalata. Results were tabulated in form of structural deformities seen.

7

Authors: Priti Garg

Spontaneous pregnancy loss is a surprisingly common occurrence with approximately15% of all clinically recognized pregnancies resulting in pregnancy failure. Recurrent pregnancy loss (RPL) is defined as three or more consecutive spontaneous losses of pregnancy. Recurrent miscarriage is thought to have multiple etiologies, including parental chromosomal anomalies, maternal thrombophilic disorders, immune dysfunction and endocrine disturbances. This review highlights the current understanding of the various etiologies implicated in RPL, including role of Yastimadhu to prevent RPL.

8

Authors: Kamble Amar Chandurkar Nitin and Rupali Bawa

This study endeavors primarily about amashay sharir & Urdhvaga Amlapitta described in ancient texts & according to modern science and then to correlate the Urdhvaga amlapitta with likewise diseases described in modern science. The strotas is unique concept of Ayurveda2 . In Ayurveda, Vyadhis are described according to strotas. According to Sushrut, moolsthan of annavaha strotas are amashay and annanalika4 . Amashay is placed in between Nabhi & Stana according to Charak1 while it is above the Pittashay according to Sushrut3 . Amashay is the seat of one of the type of Pitta i.e. Ranjak Pitta7 and also the component of Pittadhara Kala6 .As described in Purushvichay, upper part of Mahastrotas contains Annanalika & Amashay which are nothing but Esophagus & Stomach described in modern science. The symptoms of Urdhvaga Amlapitta appearently look to share the symptoms found in some diseases of upeer GI tract like GERD, Gastritis, Peptic Ulcer Disease, Functional dyspepsia described in modern science. On the basis of the present study the maximum symptoms in patients who were diagnosed as GERD9,10had the close resemblance with the symptoms stated in Urdhvaga amlapitta vyadhi10 . Moreover, this work attempts to study the changes occurring in Amashay due to Urdhvaga Amlapitta with the help of esophago-gastroduodenoscopy 9 of the patients having the symptoms of Urdhvaga Amlapitta.

8

Authors: Parashuram Pawar, S.L. Dasari, Preeti S. Dasari and Sucheta P. Pawar

Narration of Deepan Pachan paribhasha is the unique identity of Sharangdhara Samhita and Pramathi is one of them. Pramathi means by virtue of specific cleansing properties/ potency some drugs expel out the accumulated doshas from the strotasa. It is the need of time to explore these paribhasha (pharmacological actions) theoretically as well as clinically. Pramathi drugs are having teja and vayu mahabhoota dominance in them so their action is carried out with the help of laghu, rooksha, sookshma, teekshna, vishada guna , katu rasa, katu vipaka and ushna veerya. In the treatment of pureeshavegadharan Charaka has mentioned pramathi annapana also, in kshayaja kasa chikitsa, soup of meat of jangala animals which is having pramathi properties is indicated. The references of indications of maricha and vacha as in mookhdooshikahara lepa and pradhaman nasya can be interpreted and correlated with the concept of pramathi. Clinically in such conditions where doshas or aama have created the obstruction in strotasa the pramathi drugs are the choice of drug for the treatment.

8

Authors: Kiran R. Pabitwar

Ayurveda deals with cure and preventive aspect of the disease. Prevention means having concern with different factors that leads to prevention of disease as well as certain principles and rules to be followed at the time of treatment. The main motto of every physician is to achieve Samayak yoga of different Panchakarmas. There are several factors mentioned in texts which are responsible for Samyak yoga e.g. Praktuti, Dosha Desha, Matravichar Kosthavichar, inclusion and exclusion criteria for administration of any Shuddhikriya; all should be taken in to consideration. Besides all of above Kala that is the time factor which should be followed and managed meticulously. Administration of Shodhanasneha will be done at early in morning 15 to 30 minutes just after Sunrise for proper result. For Vamana ingestion of Vamanyavaagu or Vamana yoga must be taken at early in morning at beginning of Kaphakala so as to achieve Samyakyoga. In case of Virechana it is advocated that Physician should wait for cessation of early Kapha hours. After 8 am it will be administrated. Regarding Vasti vidhi it is recommended that it can be performed at evening .It is seen that occurance of Kaphaj, Pittaj and Vaataja vikaras at different age levels of human life like childhood, adulthood and old age respectively and they can be treated by Doshapratyanik Shodhana. Considering above facts one can say that there is association between Biological rhythm of Doshas and indication of Panchakarmas. A Physician who is aware of basics of Kriya Sharir can successfully handle all type of Panchakarma procedures. As he is aware of Doshaudirana and Pradhan kala (dominance time), different Awastha related to Doshas, he can administrate different indicated procedure and have a good result. This article intended to explore the importance of timely induced Panchakarma with evidential approach for better results.

10

Authors: Archana Negi, Shweta Shukla, Deshraj Singh and Bhupinder Singh

Ulcerative colitis is one of the common Gastrointestinal (GIT) disorders encountered by clinicians in day-to-day life. It is a type of Inflammatory Bowel Disease (IBD) that usually involves the mucosa of rectum and extends proximally to involve all or part of the colon. A westernized environment and lifestyle is linked to the appearance of ulcerative colitis which is associated with smoking, unhealthy diet, medication use, stress etc. In Allopathic system of medicine drugs like 5 –Aminosalicylates, Glucocorticoids, anti-TNF therapy etc. are used for its treatment but they have many side effects like headache , nausea, vomiting ,hypersensitivity reactions due to Sulfasalazine ,osteoporosis due to use of Glucocorticoids etc. On the other hand Ayurveda is the Science of life in which Humoral balance is emphasized. Use of Deepana, Pachana drugs and Pichha Vasti is quite effective in this. Role of Pichha Vasti in Ulcerative colitis is discussed in detailed in the article.

11

Authors: S. N. V. Neeraja D and Paramkusha Rao M

Ayurveda is the oldest system of medicine. It gives importance to the women health care particularly when it comes to the Prenatal and Postnatal care. After delivery women have to follow certain dietetic rules and lifestyle modification changes, mentioned in the Sutika Paricharya which helps her to restore to the Pre-pregnant status. Postpartum weight retention in the retention of women after 6 weeks of delivery is influenced by many factors that include the Gestational weight gain, stress and postpartum depression, sleep intervals, hormonal changes, and adiposity changes. This condition may lead to obesity and other metabolic disorders in future with the changes in the lifestyle.

12

Authors: Dhiman Sonia, Kumar Ajay, Dhiman Monika, Chawla Kumar Satbir and Priyanka

Kumari (Aloe barbadensis Miller) is non controversial plant, but three types of (Musabbar) aloe are sold in market i.e. Barbados aloe, Socotrine aloe and Cape aloe which are prepared from Aloe barbadensis Miller, Aloe perryi Baker and Aloe ferox Miller respectively and other inferior aloe are also sold like Natal aloes by the name of Musabbar. These species of aloe are difficult to identify hence pharmacignostical study of Aloe barbadensis Miller was done. It is coarse looking, perennial succulent plant, grown close to the ground in a typical rosette shape, Strong, shallow and fibrous roots have arbuscular mycorrhiza. Leaves are crowded on the top of the stem with spiral orientation. Dark green leaves have glaucous spots, wider at the base tapering gradually to the pointed tip, concave above, convex beneath, serrated margins. Rind, sap, mucilage gel, inner gel is layers of leaves. Flowers are born in terminal racemes on the scape.Stalked, numerous having yellow tubular corolla with six stamens. Fruits are oblong, ovoid. The micrograph of the adaxial leaf epidermal layer exhibited the characteristic plasmolyzed cytoplasm, sunken stomata complex having two guard cells, tetracytic, hexagonal epidermal cells and some cells were small square shape. In contrast, the abaxial leaf epidermal layer was less plasmolyzed and cell walls were less thick. Epidermal tissue, chlorenchyma, aquiferous tissue, vascular bundle are four type of tissues present in leaves. The Tikta Rasa was observed as the predominant Rasa of Kumari Swarasa (70%). According to 50% volunteers both Katu and Tikta Rasa were present.

13

Authors: Pallavi Singh, Premraj Chaudhary and Rohit Ranjan

Cow is equated to mother in the Indian tradition and her urine is panacea of all diseases. Cow urine is the treasure of medicines used to cure a no. of diseases since ancient times. Various researches have also proved the significance of cow urine. In Ayurveda, cow urine is used alone and also in the yogas to alleviate various health issues. In this article an attempt has been made to compile the use of cow urine in Brahattrayi to facilitate its literary research which will serve as a base for further scientific researches.

14

Authors: Shital Kolpekwar and Pradipkumar R Suryawanshi

Introduction: Grahani is very common disease in society. In present era factors like stressful life, faulty and irregular habit of food intake, lack of time for food intake and deification result in dysfunction of digestive system. It becomes weak causing Garahani roga; Pravahika, Visuchika, Aalsaka which are similar to Irritable bowel syndrome, inflammatory bowel syndrome, ulcerative colitis and chron‘z disease mentioned in modern medicine. Most of the symptoms of Irritable Bowel Syndrome are enumerated in the conditions of Vataj Grahani delineated in Ayurvedic Classics. Himashwadi Churna is mentioned in Bhaishajya Ratnawali for Grahani Chikitsa1 . Aim: To clinically evaluate the efficacy of Himanshwadi churna with or without Takradhara on Vataj Grahani(I.B.S.) Materials and Methods: In this present clinical study, total 60 patients of Grahani Roga were registered and randomly divided into two groups. In A group Himanshwasdi churna was given and Group B was given Himanshwadi churna with Takradhara therapy for 4 weeks. A clinical research performa was specially designed on the basis of the study drugs. Results: Excellent results in group A [70-80%] and in group B (70-95%) were found in symptoms like abdominal pain and abdominal discomfort. Both group showed good results [average 50-7o%] were found in symptoms like Adhmanam, Shwas, Aasyavairasya, Grudhi Sarva Rasanam, alteration of bowel habit, Shushka, Tanu, Apakvam, Fenvat Malpravrutti and average results (25- 50%) was found in Manasadanam, Karnaswana, Kruchapaka. Average percent relief in Group A and in Group B was found to be 61.47% and 74.13%, respectively. Therefore, it is more efficacious than group A as per average percent relief. Conclusion: Statistically significant improvement was observed in all the symptoms in both the groups. While in comparison Group A showed better effect than Group B. It is concluded that Himanshwadi churna with Takradhara can be used as rather than without Takradhara Vataj Grahani (I.B.S.)