Pharmacovigilance is awareness towards adverse drug reactions. As per the guidelines of WHO to AYUSH department of Ministry of Health and Family Welfare; Government of India,implemented a pharmacovigilence program for Ayurveda, as a means to ensure the safety and efficacy of Ayurvedic medicines in year 2008. Continuing Medical Education and public meetings are being conducted to raise health professional's awareness of Ayurveda, Siddha and Unani drug. Main focus of pharmacovigilance is on adverse drug reactions (ADRs) and other medication errors to minimize the risk of harm associated with pharmaceutical products. Instead it was not familiar in ayurvedic texts, but the commercialization has brought with it many challenges about safe use of ayurvedic medicines, bringing into focus the need for formal pharmacovigilance programs in the field. Pharmacovigilance system depends entirely on the alertness of physicians towards ADRs. Several challenges that preclude identification and reporting of adverse reactions to ayurvedic drugs can be identified related to detection, assessment and prevention of adverse drug reactions. Awareness should increase about the science of pharmacovigilance among ayurvedic physicians, patients and paramedical staff. Attempt should be pointed towards collecting safety data during marketing of formulation. Safety monitoring of medicines in common use should be an integral part of clinical practice. With the help of modern informatics we can make an effective attempt in this area.