International Journal of Integrative Medical Sciences

Number 2, 2015

61-69
Role of Oxidative Stress on Age and Gender

Authors: Sailaja M.V, Sharan B. Singh M, Ch. Rajendhra, N. Mallikarjuna Reddy

Abstract

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Background: Old age is an incurable disease which is more affected by the oxidative stress by damaging the DNA and disruptions in normal mechanisms of cellular signaling. There are dates which show possible role of oxidative stress and disturbance in antioxidant mechanisms in various disorders. Materials and Methods: A cross-sectional study was undertaken for a period of 12 months with clinically normal 109 subjects at the Narayana General Hospital, Nellore. Were divided into 6 groups (decade a group) and target for the level of Malondialdehyde (MDA) a lipid peroxidation product and marker of oxidative stress and protein carbonyls (PCO) levels reflects the protein oxidation process. Reduced Glutathione (GSH) is a representative of antioxidant potency of glutathione system in erythrocytes, and Uric acid (UC) for the antioxidative capacity. Result: Increased MDA, PCO, and uric acid levels. Decreased GSH levels were found. MDA and PCO significantly positively correlated. GSH significantly negatively correlated. UC was not associated with age. MDA, PCO, and GSH levels are independents of age. UC have significant gender difference. MDA and PCO were having strong negative correlation with GSH. MDA, PCO, and UC levels are significantly high in above 50 years compared to blow 50 years. GSH levels are significantly low in above 50 years compared to blow 50 years. Conclusion: Oxidative stress (MDA & PCO) increases with age and antioxidant activity (GSH) decreases with age. Uric acid (antioxidant) increases with age but gender difference is seen. Oxidative damage in the cell is accumulating with age and there is simultaneous decrease in the antioxidant capacity. Thus, Oxidative stress is considered as one of the causes for Aging and Age related diseases.

70-77
Effect of Construction and Flour Mill Air Pollution in Rural Area

Authors: G. Madhavi Latha, K.Sarala, Shivakrishna Gouroju.

Abstract

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BACKGROUND: chronic obstructive pulmonary disease (COPD) is a seventh leading cause of death and disability in the worldwide. For better living we need civilization, under these unignorable inherent maladies particles affecting the people. India like traditional and developing countries is requiring two of the major works flourmill and constructions. Now we are searching how much this work affecting the works. MATERIALS AND METHODS: A cross-sectional study was undertaken for a period of 12 months with 15 clinically normal and 80 COPD subjects at the Govt.General Hospital, Kurnool and from small villages in and around of Kurnool, various flourmills and labourers for construction work, were divided into 6 groups based on the work and experience and target on the respiratory parameters. RESULT: Flourmill and construction works respiratory parameters are compared with the normal subjects. The levels FVC (0.01, 0.00, 0.00, 0.00, 0.00) and FEV1 (0.22, 0.02, 0.00, 0.14, 0.06) which are more dependent on the volumes and capacities are reduced. The values of PEF (0.00, 0.00, 0.00, 0.00, 0.00) and PIF (0.51, 0.14, 0.09, 0.00, 0.00), which are more dependent upon the airways are very much reduced, because the effects of the pollutants are more on bronchial tree. Conclusion: pulmonary function tests like FVC, FEV1, PEF, and PIF have been conducted on flourmill workers and construction workers for the levels are vary period of exposure. The results suggest that COPD is common in these workers and the changes are more related to the period of exposure. These respiratory disorders are preventable if proper precautions are taken either by decreasing the concentration of pollutants or by rehabilitation of patients since the disorders are more related to the period of exposure.