The Pharmaceutical and Chemical Journal

10-28

Authors: PE Omale, SO Okeniyi, AO Aliyu, UV Agbogo

A healthy nation is a wealthy one. One can conclude that a nation full of drug abusers is a nation set for destruction and without labour force for the economic development. Since the youths are future leaders of any nation, problem of youths should become problem of all and the welfare of the youths should be the welfare of all as they constitute the labour strength for the nation that work hard for economic development. A drug free Society is the one with viable workforce. Working age of every country determines the extent of the economic development of the country; hence the Society, Family, School and Worship Centres are expected to mentor, monitor, train and develop the capacity of the youth by building a positive values system. This paper focuses on the concept of drug abuse, types, theories of causes, signs and symptoms, effects, and strategies for counselling.

31-36

Authors: Arash AlizadehYegani*, HalilMahir Kaplan, Ergin Şingirik

Studies have shown the antioxidant and anti-inflammatory activity of alpha-linolenic acid, one of the omega 3 fatty acids found abundantly in linseed oil. Cigarette smoke causes impotence as it contains many harmful components and increases oxidative stress. Therefore, we planned to investigate whether or not alpha-linolenic acid has protective effect against impotence due to cigarette smoke exposure. For this purpose mice were given cigarette smoke and 200 mg / kg alpha-linolenic acid gavage for 8 weeks And phospholipase A2, inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) enzymes in corpus cavernosum tissues were analyzed by ELISA. Application of cigarette smoke to the mice reduced the enzyme eNOS while boosting corpus cavernosum cyclooxygenase-2 (COX-2), phospholipase A2 and iNOS. Administration of alpha-linolenic acid to mice exposed to cigarette smoke refused the increase in COX-2, phospholipase A2 and iNOS enzymes and caused an increase in eNOS enzyme. In conclusion, our study has shown that smoking is the cause of impotence due to the increase of inflammatory mediators and the reduction of eNOS enzyme responsible for erection, and that the use of alpha-linolenic acid with smoking is beneficial against these effects.

43-45

Authors: Robson Fernandes de Farias

Combining quantum chemical thermochemistry and experimental data from literature, a series of thermochemical parameters (ΔsolvHθ; ΔcrgHθ; ΔcrlHθ; ΔlgHθ; ΔfgHθ; ΔflHθ; ΔfcrHθ; Cv and Cp) were obtained for 2,4-dimethylglycoluril (2,4-DMGU), 2-6-dimethylglycoluril (2,6-DMGU) and 2,8-dimethylglycoluril (2,8-DMGU).

55-74

Authors: Kalyan Hazra, Sreya Dutta, Achintya Kumar Mandal, Dhirendra Nath Mondal, Jayram Hazra

Aegle marmelos (L.) Corrêa is a medicinal and dietary plant species with traditional and folk uses since millennia. Numerous numbers of phytochemicals present in the plant are responsible for diversified pharmacological activities. Brief discussions on plant pharmacognosy, pharmacology are included in this article. The authors of this review put an immense emphasis on phytochemicals isolated from the plant. The article also summarizes the extensive study of spectral data on phytochemicals.