The Pharmaceutical and Chemical Journal

9-16

Authors: Devesh Kapoor, Ruchi B Vyas, Chaitali Lad, Manish Patel, Basant Lal, Ruchi Parmar

The objective of the current research work was to explore the potential of emulgel in enhancing the topical delivery of piroxicam. Emulgel formulations of piroxicam were prepared using three types of gelling agents: Carbopol 934, Xanthan gum and HPMCK15M. Based on solubility studies Tween-80 and Span-80 as emulsifiers and propylene glycol as co-surfactant were selected for preparation of emulgel. The persuade of the type of the gelling agent on the drug release from the prepared emulgel was investigated. The mentha oil is used as permeation enhancer. The formulated emulgel were characterized for their physical appearance, pH determination, viscosity, spreadability, in vitro drug release, ex vivo drug release, skin irritation test, anti inflammatory activity, analgesic activity and stability studies. All the prepared formulations showed acceptable physical properties, homogeneity, consistency, spreadability, viscosity and pH value. In-vitro release study demonstrated diffusion controlled release of piroxicam from formulation up to 8 h. The drug release profile exhibited zero order kinetics.

25-27

Authors: Puneet Sudan, Tapan Behl, Shaveta Sharma, Swati Sabharwal

The efficacy and potency of Hibiscus sabdariffa (HS) in the treatment of risk factors associated with various cardiac and hypertensive disease is presented in this paper. Anthocyanins found in abundance in Hibiscus sabdariffa sepals are generally considered the phytochemicals responsible for the antihypertensive and hypocholesterolemic effects. Decoctions and infusions of sepals and tender leaves are used in whole world in the treatment of hypertension, hyperlipidemia and various cardiovascular ailments with no reported adverse events or side effects, except for possible adverse hepatic and renal effects at increased doses ie more than 5000mg/kg/day. The daily consumption of extract produced from Hibiscus sepals significantly decreases systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults with pre to moderate essential hypertension and type 2 diabetes. The studies revealed that effectiveness of extract is equivalent to Captropril, but less effective than Lisinopril. This comprehensive body of evidence suggests that extracts of Hibiscus sabdariffa sepals are promising in the treatment of hypertension and hyperlipidemia in diabetes -II patients. For the study, 60 volunteers suffering from diabetes with mild hypertension were recruited. But volunteers were devoid of any kind of medication for hypertension, hyperlipidemia or high cholesterol levels. The patients were randomly grouped into two groups HT and BT and asked to drink infusions of Black tea (BT) and HT (Hibiscus tea) twice a day for a month. Their BP was measured uniformly at regular intervals. The mean of Systolic BP decreased from 134.4±11.8 mmHg to 112.7±5.7mm Hg with HT after one month; whereas in case of BT group measure changed from 118.6±14.9 to 127.3±8.7 mm Hg.