Anti-Malarial Activity of the Ethanolic Extract of Vernonia Amygdalina (Bitter Leave) on PCV and Parasiteamia of Experimental Mice
Authors: Yohanna Longdet Ishaya, Matawal Mary Mankilik, Obed Faven Rimzhi, Edward David Idoko
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Malaria is one of the most important infectious diseases in the tropics and sub-tropics. The search for antimalarial compounds has been necessitated by P. falciparum resistance to almost all antimalarial drugs. In this study, the in vivo antimalarial activities of ethanolic extracts of Vernonia amygdalina, a plant used by traditional healers to treat malaria and other diseases was carried out. Twenty-one (21) Albino mice were randomly divided into seven groups of three mice each (n = 3). Group 1, 2, and 3 were the experimental group, while group 4, 5, 6, and 7 were treated/untreated, normal, uninfected/treated and standard respectively. Groups 1, 2, and 3 were treated with dose of 200 mg/kg. bwt, 300 mg/kg. bwt and 400 mg/kg. bwt respectively. The average daily parasitaemia level of the Plasmodium berghei infected mice treated with 300 mg/kg. bwt of the ethanolic leaf extract of Vernonia amgdalinaextract and 25 mg/kg. bwt of chloroquine significantly (P < 0.05) reduce when compared with negative control group. However, there is no significant (P > 0.05) different in the level of parasitaemia in 200 mg/kg. bwt and 400 mg/kg. bwt at the varying concentractions of the ethanolic extract’s dosage, Therefore, this shows that Vernonia amygdalinahas both curative and suppressive activities since at lower concentrations, the parasite was seen to reduce from the initial load before administration and at higher concentrations, the parasite was seen to reduce to the lowest level indicating that if treatment period is extended concentration is administered, the parasite will be cleared completely, thus, the curative activities of the Vernonia amygdalinaleaf extract.