International Invention Journal of Medicine and Medical Sciences

Number Vol. 3(3), 2016

44-49
Comparison between Corneal Collagen Cross-Linking with Epithelial Removal and Transepithelial for Management of Progressive Keratoconus

Authors: Mohamed El moddather MD

Abstract

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Number of views: 362

This study aim to compare the efficacy and safety of corneal cross linking (CXL) with and without removal of epithelium for treatment of progressive keratoconus. One eye of 16 patients with bilateral progressive keratoconus was randomly treated by corneal cross linking (CXL) with epithelium removal (group I) while the fellow eye underwent corneal cross linking (CXL) without epithelium removal (Transepithelial CXL group II). Visual acuity, refraction, corneal topography was evaluated at after 3, 6, and 12 months. In both groups uncorrected and corrected distance visual acuity improved significantly after treatment. There was a significant improvement in topographic outcomes, spherical equivalent and astigmatism in both groups at one year postoperatively. Postoperative pain was significantly less and shorter in duration in group II. The most significant difference between epithelium removal CXL and intact epithelium CXL (Transepithelial CXL) was short recovery as regard pain and epithelium healing. Both techniques were equally safe and effective in stabilization of keratoconus.

50-57
Presence of Thyroid Disorders in Patients with Autoimmune and Autoinflammatory Rheumatic Diseases

Authors: Sibel Atalay1*, İbrahim Tekeoğlu2, Halil Harman2,3, M. Şevki Uyanık4

Abstract

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Number of views: 354

Association between rheumatological and thyroid disorders has been demonstrated by many studies. Our aim was to evaluate the prevalence of thyroid disorders in patients with autoimmune (ARD) and also autoinflammatory rheumatic disease (AIRD). We evaluated serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4), and titers of antithyroglobulin (TG-Ab) and antithyroid peroxidase (TPO-Ab) antibodies in 298 patients with ARD and 363 patients with AIRD. We also recruited 137 age-matched controls. Ultrasonography (US) of the thyroid gland was performed in all subjects. Comparisons were done only among participants of the same gender. Hashimoto’s thyroiditis (HT) frequency was significantly more frequent in patients with ARD or AIRD in female population and also it was more frequent in patients with ARD in male population than in controls. In both female and male patients with ARD, mean TPO-Ab levels was lower than those receiving biologics than those receiving disease-modifying antirheumatic drugs (DMARDs), but difference was not significant. Receiving nonsteroidal anti-inflammatory drug (NSAID) was more frequent in female patients with ARD and AIRD and also in controls than those not having HT. Our study shows a significantly higher prevalence of thyroid autoimmunity in patients with ARD and AIRD as compared to controls. Female gender has an important role for HT diagnosis. We suggest that thyroid function tests should be a part of the clinical evaluation particularly in female patients and also male patients with ARD and AIRD.