Recent Advances in Colon/Colorectal Cancer Biomarker Developments
Authors: Sanjay Kumar Pandey, Sweta Pandey, Sudhakar Dwivedi, Naresh Bajaj
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Cancers of the colon and rectum known as colorectal cancer. Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Colorectal cancer usually begins as a slow-growing, non-cancerous polyp, which can progress over time to aggressive cancer. If a cancerous polyp is not removed, it can enter the lining of the large intestine, causing the cancer to spread to other organs through the blood or lymphatic vessels. With screening, it is possible to detect and remove polyps before they become cancerous. The increase in colorectal cancer awareness and screening has contributed to an overall decrease in the incidence of colorectal cancer over the past 30 years. Scientist have learned a lot about colorectal cancer, but it needs more research to find ways to prevent and detect the disease earlier. It is difficult to detect in the early stages. However, secretory proteins have been used as an ideal biomarker to detect the progression of colon cancer in cancer patients. Colorectal cancer detection techniques at the molecular level have facilitated the development of new signature drugs designed to inhibit unique pathways of colorectal cancer development and immunity.Serum/tissue protein expression may help general practitioners to identify colon cancer in earlier stages. Recently, the discovery of biomarkers is important in cancer biology and disease management. DNA, RNA, metabolites, enzymes, mRNAs, aptamers, and proteins biomolecules may help an early prediction of disease. This review explains recent advances on new developments in molecular markers associated with colorectal cancer.