ANFIS controller for the active vibration control (AVC) of a flexible plate with single input and single output fashion is designed tuned with LQR controller. ANFIS controller is one of the best controllers to control a specific action. MATLAB simulation software is exercised to design it effectively and with highly accurate results. Finite element modeling of plate is done to perform all tests. The LQR controller is utilized to make ANFIS controller for active vibration control by changing parameters like length, breadth, thickness of plate, sensor location and initial displacement to the smart structure. The accuracy of the ANFIS controller results are demonstrated by applying various random inputs that shows the robustness of the proposed controller.