The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

9-13

Authors: D.Е. Petrenko

Using finite element method comparative analyzes of the stress-strain distribution of the single-rod and double-rod instrumentation for anterior «bone on bone» spinal fusion was done. It was revealed that the most loaded zones of the «thoracic spine-implant system» are rods and anterior parts of the vertebral bodies at the apex of the kyphosis. Close contact of the vertebral bodies in instrumented spine spares physiologic loading of the spine.

20-25

Authors: A.L. Kulik, A.K. Zaderihin, V.I. Shulgin, М.I. Iabluchanskyi

At the 4 healthy volunteers aged 22 to 29 years (2 men and 2 women) with a body mass index from 21 to 23 individual characteristics and general regularities of heart rate variability (HRV) frequency dependence were examined. It is shown that the frequency of paced breathing significantly affects the power and structure of the HRV spectrum and regulation in general. Increasing of LF domain of the HRV occurs on breathing frequencies 5-8 per minute. Increasing of HF domain of HRV occurs on breathing frequencies 9-13 per minute. Changes in TP of HRV are more related to the LF and less to HF domain. Biofeedback with different programs of changing in the paced breath frequency can be a powerful tool of intervention in the regulation and quality of life.

31-39

Authors: М.S. Maltseva, L.O. Martymianova, О.O. Vlasenko, V.M. Savchenko

The clinical pharmacology of inhibitors of angiotensin converting enzyme (IACE) in the classification system of ATS is described. Clinical classification, pharmacokinetics and peculiarities of drugs of this group are submitted. Indications for use and features of use of ACE inhibitors in a therapeutic clinic are considered. The emphases of this group of drugs are placed for hypertension, heart failure and ischemic heart disease. The primary contraindications, emphases of interaction with other drugs, side effects and symptoms of over-dose are given.

49-58

Authors: K.V. Vovk , O.V. Sokruto, J.Ya. Nikolenko, V.N. Savchenko

During more than one hundred years of researching pathogenesis of chronic pancreatitis (CP) many of the hypothesis have been created. Some of them through time were denied, some were partly confirmed by results of clinical and experimental researchings and became hypothesis. However, not all the elements of pathogenesis of CP are clear till now. Probably, it is caused by large number of etiologic factors in development of CP, part of which have differences in pathogenesis. The hypothesis of 60s-70s of the last century were propounded and refuted exactly without taking into account these differences. The discoveries of the last 15 years, specifically determination of hereditary and autoimmune genesis of CP, have widened a notion of it’s pathogenesis. The majority of scientists consider a pathogenetic significance of the intraductal hypertension and intraductal protein and calcium precipitation. However, in opinion of some researchers, the mechanisms of its’ development are different. The fundamental pathophysiologic hypotheses of CP’s development, many of which are topical today, are considered in this article.

64-73

Authors: N.P. Kopytsa, N.V. Tytarenko, N.V. Belaya

The article summarizes the available data of clinical trials, registries and current guidelines about reperfusion therapy in patients with acute coronary syndromes with ST-segment elevation on electrocardio-gram. There were considered the role and place percutaneous coronary procedures and pre-hospital thrombolysis in medical care system in such patients. Pre-hospital thrombolysis can considered as method of choice in our country and it must be supplemented with system or rescue percutaneous coronary intervention.

97-101

Authors: V.A. Savchenko

Responsibility of medical workers has set of nuances. In the legislation of Ukraine many questions connected with the given theme are not opened. In the certain measure, the given problematics is studied by criminal law, but administrative and especially civil sphere of law contains set of legal blanks. Feature of regulation of a question of responsibility of medical workers consists that they are special subjects правоот-ношений so possess the special rights and duties, their status is separately considered by the legislator. In a context of understanding of medical workers as special subjects law it is necessary to consider questions on their legal responsibility.