The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

5-9

Authors: V.P. Tretyak, P.P. Ryzhko

The necessity of improving the Law of Ukraine regarding HealthCare, in correspondence with the modern socio-economic circumstances Ukrainian population vital functions for providing effective and high-quality medicare, principal reorganization and modernization of medical network, staff, new schemes of financing, economic management, technological communications and methods of the Health Care system.

14-18

Authors: E.S. Protsenko, N.A. Remnyova, A.O Ponomaryov

For the first time, the structure of thymus disease incidence in Kharkiv region within the period of 1990-2005 was investigated and analyzed. Two hundred and forty four cases of thymus diseases (173 women and 71 men) were registered during this period. The most frequent disease of the thymus in women is hyperplasia, in men – lymphoepithelial thymoma.

23-29

Authors: I.V. Griga, V.I. Griga

The removing of the kidneys under the skin of white rats results in the development of hypertension and the increase of oxygen absorption by the tissues of the body. These processes are stimulated in case of additional physical exertion by swimming in the water-pool. Giving the extracts of Astragalus glycyphyllus, Astragalus cicer, Veronica officinalis, and as well as Melittis melissophylum and Eleagnus angustifolia to the experimental animals with kidney hypertension and physical exertion contributes to the decrease of arterial pressure, cholesterine and beta-lipoproteids, to the normalization of tissue breathing and peroxidation of lipids.

35-40

Authors: E.M. Krivonosova

It was performed the investigation of gastric and duodenal mucous layer functional condition in patients with insulindependent diabetes mellitus. It was characterized pH-metric, endoscopic and pathomorphologic percularities of gastroduodenal system on a background of diabetic gastropathy, chronic gastritis and duodenal ulcer. The conclusion about expediency of H. pylori eradication therapy, metabolic, prokinetic and immunotrophic medications assignment for the treatment of diabetic patients with gastrodudenal disorders.

43-46

Authors: G.A. Oleinik

There were detected a lot of morphological changes of internal organs in patients after the general and local cold injuries.

49-52

Authors: E.A. Romanova, A.V. Martyno, N.I. Igumnova, T.A. Sidorenko, V.I. Chernyavsky, M.V. Smelyanskaya, S.D. Peremot

In the article were presented results about studied of immunopotential activity of new IL-2 – acylated derivatives. It was show, that preparation much increased spontaneous blasttransformation of lymphocytes in mice as in vitro and in vivo. Added of acIL-2 to lymphhocete’s cells culture resulted to more increasing of mitotic activity of lymphocytes than in control with native Roncoleukin.

55-60

Authors: V.O. Fedoryshcheva, М.І. Yabluchansky, W. Arnold, E.O. Naumova

It was the aim of this study to compare two different methods of linear and angular craniometric measurements of the neuro - and viscerocranium. Of 38 normal skulls of adult individuals from Verhnij Saltovskij moglinik lateral x-rays were taken with a PYM-20 x-ray machine at 40-45 kV electron beam and an exposure time between 0.1 to0.2 sec. As base points for the measurements served either the center of the sella turcica (point S), or the back edge of the tuberculum sellae (point S’). Linear and angular marks were measured between the following points: Ba, B, L, N, O, Or, Pr, S, S', Fca. The mean value (M, cm), standard quadratic deviation (sd) were determined. Statistical analysis between groups was carried out using the Mann-Whitney test. The results showed distinct differences between linear and angular measurements using the different base points. It is concluded that in anthropological research for craniometric measurements the internationally recommended S point as standard base point should be used.

67-71

Authors: А.I. Thsivenko

The results of the intraoperative diathermy knife and ultrasonic scalpel use are presented in the paper. The indices of lipid peroxidation and chemiluminiscentia are explored in the experiment on Shinshilla rabbits and one hour later after the surgical procedure and on the third, seventh, fourteenth, thirtieth day of postoperative period. The gastrotomy performed with the help of a diathermy knife and ultrasonic scalpel leads to consider-able activation of lipid peroxidation in tissues by means of free radical lipid oxidation and to reduction of garter tissues resistance for lipid peroxidation that becomes apparent in increase of tiobarbituric acid of active products concentration and chemiluminescence’s intensity evoked by Fe2+, and Н2О2. The ultrasonic scalpel application results in less apparent patologicprocess in the zone of action than the ultrasonic scalpel application that, doubtlessly, leads to more favorable postoperative period and reduces the risk of complications development.

76-80

Authors: P.A. Garkaviy, А.Yu. Saraeva, N.I. Yabluchansky

A dependence of diastolic arterial blood pressure (DABP) changes during the clinostasis – orthostasis transition in patients with essential arterial hypertension (AH) is studied. 154 patients with AH were surveyed (58 males and 96 females) in the age of 63±7 years. Average duration of disease was 10,4±7,8 years. 48 patients diagnosed soft AH, 55 – diagnosed mild AH, 51 – diagnosed severe AH. Depending on DABP reaction in the orthostatic test patients were divided into groups: increase of DABP – group 1 (hypertonic type), unchanged DABP – group 2 (isotonic type), decrease of DABP – group 3 (hypotonic type). Criterion of DABP increase and decrease were its corresponding changes in the magnitude not less than 5 mm.hg. During the transition from clinostasis to orthostasis DABP increased in 56,5% of patients (in 62% of males and in 53,1% of females), DABP did not change in 19,5% of patients (in 13,9% of males and in 22,9% of females), DANP decreased in 24% of patients (in 24,1% of males and in 24% of females). High frequency of hypertension and hypotension types of orthostatic reactions in patients with АH indicates on the meaningfulness of aimed analysis of these types of autonomic regulation disorders during transition processes.

83-88

Authors: O.О. Gunaeva-Kruchina

During the investigation 40 out – patients with chronic ischemic heart disease (CIHD) 18 – without 22 – after aortic–coronary bypass (acb) were observed. The average period of time after operation before initial investigation comprised (13, 5) years. Patients were divided into 2 groups according to the types of dislipoproteidemia. 10 patients without асb has 2a type of dislipoproteidemia, 8 – 2b type, 15 patients after aortic–coronary bypass – 2a type, 7 – 2b type. Аll patients received atorvastatin 10 mg. Dynamics of clinical state evaluates by patient complaints of dispnea, angina pectoralis and stability of physical loards. Total cholesterol, LDL, VLDL, HDL, triglycerides, index of atherogenity were evaluated ones at 3 months. During the therapy the optimization index of lipid spectrum and clinical state indices was noted in all patients, without regarding aortic coronary bypass and grade of dislipoproteidemia. Durig the investigation after 3 months it came the decrease of lipid level and angina pectoralis attack, increase stability of physical loards.

93-96

Authors: N.V. Kalinkina

The anthracycline antibiotics cause infringement of a heart rate variability (HRV). The purpose: to study influences of nebivolol on HRV at the patients receiving anthracycline antibiotics. 73 patients (in the age of 24,5±5,1 years) receiving anthracycline antibiotics which are taking place in a remission on oncohaematological disease and not having pathologies of cardiovascular system were randomized on 2 groups: in 1-st - 37 patients receiving nebivolol in a doze 5 mg 1 times per day, in 2-nd - 36 patients without therapy by β-adrenoblocker. Control group is 30 practically healthy persons. Prior to the beginning therapy by nebivolol and after 6 months the daily monitoring of ECG with an estimation of time and spectral parameters of HRV was carried out. At initial investigation of the patients receiving anthracyclines the decrease of HRV, activation of sympathetic and deppression of parasympathic vegetative nervous system in comparison with the control was observed. At the patients accepting nebivolol through 6 months the increase of HRV, decrease of sympathetic and increase of a parasympathic tone by comparison to the 2-nd group was observed.

100-104

Authors: N.A. Kravchun

The maintenance of plasminogen activator inhibitor-1 (PAI-1) in blood serum in patients with type 2 diabetes mellitus of the senior age group with long term of disease and the role of this index in the development of cardiovascular complications were studied. The statistically significant dependence of PAI-1 on arterial hypertension, fibrinogen, triglycerides, very low density lipoproteides, body weight index and insulin resistance was determined. It was shown, that PAI-1 was a significant additional risk factor in the development of cardiovascular diseases in patients with type 2 diabetes mellitus.

109-112

Authors: V.О. Sirik

104 patients with arterial hypertension were inspected. Estimation of patients well-being, clinical criteria of arterial hypertension, interleukin-8, , E-selectin, veloergometry, EKG was conducted. The obtained results were estimated by statistical methods. It is determine, that strengthening of endothelial dysfunction in reply to veloergometry is related to development of pathological changes in endothelium which come at pro-gression of of arterial hypertension. As a criterion of prognostication of further development of arterial hyper-tension comparison of types of reaction of hemodynamics on the exercise stress with estimation of endothe-lium activity can be chosen.

117-119

Authors: Yu.K.Vasylyev

The role of the Society of the Odessa physicians, its full members in formation and its becoming of the phagocitic theory of I.I. Mechnikov is shown.