The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

6-10

Authors: R.Ya. Abdullajev, O.V. Grishenko, V.V. Bobrytska

With the applicationof Colour and Impuls Doppler regimens the main features of utero-placental and fetal-placenta blood circulation of 68 pregnant women with placental insufficienty were examined. The main quaialitive characteristics of the critical disturbance of blood circulation were the appearance of notch on the diastolic part of Doppler spertrum of uterine artery after 20 weeks gestation and reverse blood flow in the spectrum of mid-cerebral artery and umbilical artery.

14-17

Authors: I.V. Afanasiev, Yu.S. Paraschuk

30 pregnant women research with normal function of thyroid gland and 30 pregnant women with thyrotoxicosis.Morphological research of placenta with using histochemical and stereometrical methods.It was revealed features of chronicle placental insufficiency on the background of chorion vascularisation disturbances, reinforcement of involutive and sclerotic processes in pregnant women with thyrotoxicosis. Thyrotoxicosis in pregnancy caused disturbances maturation of villous chorion, which leads chronicle placental insufficiency. Thus, thyrotoxicosis complicates current of pregnancy and requires prescription of adequate therapy.

20-23

Authors: O.V. Belkina

In the article information of radiological researches of changes of adaptations of organism of pregnant is resulted with preeclampsia and stress dysbiosi at cellular level. The conducted researches showed the decline of level of cyclic a. monophosphate (cАМP) at pregnant with preeclampsia by comparison to healthy, that testifies to exhaustion of possibilities of adaptations of organism of pregnant and can be the early signal of these violations at cellular level. A correlation analysis testifies pathogenetic connection between the stage of preeclampsia, dysbiosis and system of urgent adaptation at preeclampsia.

26-30

Authors: V.V. Bobritskaya, O.V. Grischenko, P.Ya. Abdullaev, S.O. Pozdnyakov

The article presents ultrasonographic results of transvaginal colors and impulse dopplerography in 49 women with infertility. It were studied ultrasonographic criteria of polycystic ovarian desease, unovulation and lutheal phase insufficiency. The basic parameters of diagnostics were index of resistance and degree of vascularization in the growing follicle and corpus luteum.

35-37

Authors: M.O. Bortnyi, I.O. Kramnoi, I.A. Voronzhev, R.Yu. Churilin

Analysis of x-ray postmortem pathomorphological comparison of 10 premature neonates allowed to identify hyaline membrane syndrome. Six of them developed neonatal pneumopathies (hyaline membrane diseases), 4 - hyaline membranes at pneumony. It has been confirmed the certain value of excessive ventilation respiratory volume in the pulmonary affection development mechanism.

40-44

Authors: I.A. Voronjev

The purpose of work was to study radiological displays change of lung at children of early age with patrimonial damages of CNS. Roentgenograms of chest organs of 63 children till 1 year were investigated (36 boys and 27 girls). They were treated with the diagnosis: hypoxic-ischemic defeat of the CNS, the acute period, serious current, skull cerebral trauma. For verification of the diagnosis ultrasound examination of heart and a brain, roentgenorgaphy of skull and cervical department of a backbone, and also complete clinical-laboratory examination were carried out. MRT of brain (14,3%). Dynamic observation is carried out above 24 children (38,1 %). 25,4 % of patients diagnosis confirm on post-mortem examination. Most often and early radiological attributes of shock lung (SL) were changes of pulmonary drawing (42,9 %) due to the development of the interstitial edema and infringement of a hemodynamics – 1 stage of SL. At progress of the desease small focuses (0,2-0,4 mm) were determined, somewhere merging among themselves (20,6 % – 2 stage of SL). Development of 3 stage of SL was marked in 25,4 % of patients and at X-ray it was shown by decreasing of a transparence of a pulmonary tissue, occurrence of larger focal shadows (0,6-0,8 mm) with the indistinct contours, merging among themselves, pulmonary drawing was badly differentiated. In 11,1% of cases diffuse decreasing of a lung transparence was determined, pulmonary drawing and roots were not differentiated, free strips of bronchuses on a background of blackout of pulmo-nary fields are marked also, that is characteristic for hyaline membranes – 4 stage of SL. Bronchopulmonary dysplasia, as a manifestation of 5 stage of SL was revealed in 6,3 % of patients. Associated pneumonia was determined in 30,1 % of cases. Segmentary and subsegmentary atelectases are marked in 46 % of patients. The radiological method is conducting examination in an establishment of the diagnosis of shock lung in children of early age with perinatal CNS lesions. For the given group of patients absence of precise staging and often complications such as pneumonias and atelectases is habitual.

47-50

Authors: V.V. Grabar, E.A. Yacovenko, L.G. Nazarenko, E.N. Babadganyan

The traditional antenatal preparation with estrogens is frequently not effective. In this study we applied desaminooxytocin or Pg Е1 (misoprostol) for induction of labour in patients of hight-risk pregnancy. Revealed that desaminooxytocin or prostaglandin E1 (intravaginal, intracervical or intrabuccal using) is more effective for decrease of frequency of delivery complications that estrogens. Prostaglandin E1 application is move pref-erable in case of hypertensive maternal disorders.

54-57

Authors: I.A. Guz, Y.S. Parashuk

The research was carried out to evaluate the condition of lipid metabolism in women with a fibro-myoma of the uterus and obesity. The obtained data made it possible to us ”Duphaston” drug in order to normalize the genital condition of women at the preoperative period.

61-66

Authors: V.L. Dudko, I.V. Lakhno, G. V. Storchak, O.V. Grishchenko, L.V. Dudko, N.V. Lisitsina

For the recent years the increase of vaginal candidosis morbidity frequency on a background of change in the sorts of structure of mycotical agents accompanied with obvious increase of densities Candida nonalbicans and occurrence of drug resistance to the majority of antimycotical preparations has been marked. We have carried out investigation of efficiency of intravaginal ketoconazolum application compared with unitary fluconazolum reception in gynecological patients and intravaginal natamycinum usage in pregnant woman. On the basis of the received data is proved that ketoconazolum application is an optimal theraputical method at realization of monotherapy within 10 days at pregnancy and 5 days in nonpregnant women.

69-72

Authors: E.V. Zoloto, L.A. Matytsina

Investigation of the link between psychological stress and hormonal changes, participation of the endocrine system in pathogenesis of pubertal uterine bleedings put forward the study of neurohumoral mechanisms of not only active (stress-reactions) but also passive (anti-stress reactions) which represent a way of adaptation of the organism to the permanently changing surrounding conditions. According to the literature the main danger of our time is the lack of the ability to resist the stress of current life. Important aspect of this problem is the study of hormonal anti-stress mechanisms, which in contrast to stress reactions are investigated insufficiently.

76-79

Authors: V.P. Kvashenko

Prevention and treatment of infection of urinary tract have particular significance in pregnant women, because there is dangerous for mother and child health. Under our surveillance were 60 women with different symptoms of low urinary tract infections. Was used Monural. It show high effective ness without side effects. Was provided analysis of pregnancies and deliveries out cams and it showed absence of intrauterine infections in newborns, bourns from mothers, received Monural during pregnancy.

82-86

Authors: I.Yu. Kuzmina

The researches on revealing damaging of the perinatal factors on state by fetus were carried out. It was shown that perinatal outcomes at symptoms of growth retardation fetus (SGRF) were largely determined by fetal hypoxia, expressiveness of a growth retardation of fetus and method of delivery.

89-93

Authors: I.V. Latisheva, N.Е. Heintz

Retrospective clinic and statistic analysis of 1813 history cases was made. There are 14,9% cardiovascu-lar pathology was founded. 4% parturient women had this kind of pathology. The pregnancies at this group complicated by obesity, IUGR and preeclampsia. Hysteromyoma had place at pregnant with associated cardiovascular pathology. Treatened preterm labor and pyelonephritis complicated pregnancy of patients wit vascular pathology offenly. Pregnant women with cardiovascular pathology had pathologic labor (especially cesarean section), potential perineal rupture, anomalies of uterine activity frequently than preterm membrene rupture. It was founded that pregnancy complications are not specific ant not depended on character of cardiovascular pathology. This circumstance cause nessessity furthes differential study of their pathogenesis.

99-102

Authors: S.A.Levenets, T.A.Nachotova, T.S.Vvedenskaya, A.V.Goloborodko, S.H.Cherevatova

In simultaneous investigation of hormonal status of the organism and dopplerometry of the vessels of small pelvis organs in adolescent girls, aged 15 to 17, with menstrual function disorders in the form of oligomenorrhea and secondary amenorrhea there has been established the dependence of uterus and ovaries blood supply on the levels of serum lutropin, sex hormones and cortisol. A decrease in estradol and testosterone concentrations brings to slowing down systolic blood flow in uterine and ovarian arteries, and hypercortisolemia is accompanied by blood flow acceleration only in uterine artery.

106-109

Authors: A.S. Likhachova, S.M. Korovaj, I.V. Poltoratskaya, O.V. Kogut

It was assessed with immuno-assay analysis Ig, G, M, A level in 5658 pregnant and 499 newborn infants blood serum level. It was determined high score of TORCH and STD's agents in Kharkov pregnant patients and newborn infants. We had performed a conclusion about insufficient obstetricians and gynecologists knowledge in the field of gained tests evaluation. Delayed treatment of newborn infants was associated with such incompetence. The result was high neonatal mortality rate due to infections reasons.

112-114

Authors: L.G. Nasarenko, E.A. Yakovenko, A.V. Hristich, I.A. Gadan, V.V. Grabar, O.V. Romadina, E.N. Babadganyan

The advantages of the prenatal diagnosis of fetal pathologies due to combined using of the modern methods has been shown.

118-120

Authors: Yu.S. Paraschuk, Nader Kh. N. Daoud

The condition of uterine-placental and fetal circulation was investigated in pregnant with varicose veins of the lower extremities. It was established that the parameters of uterine-placental and fetus circulation are reduced in this pathology. Complex Dollper study of uterine-placental and fetus circulation can be used in early diagnosis of pregnancy complications in women with varicose veins of the lower extremities.

123-127

Authors: S.A. Pozdnjakov, R.Ya. Abdullajev, O.V. Grischenko, V.V. Bobrytskaya

The results of transvaginal ultrasound investigation in the mode of colour and impuls Doppler from the 68 women with the adenomiosis and endometriosis are represented, the features of different degrees of the adenomiosis were found. The main criterions of endometriosis were the endometrioid getherotopies like anechogenic structures with hyperechogenic circle, grind-disperse suspension registered in cervix. The main line characteristics are frontodorsal uterine measuring, asymmetry of their size, cervical thikness. The impo-rtance of colour and impuls Doppler is in the exception of the cancerogeneous processes

130-134

Authors: V.V. Simrock, V.S. Cherkasova

A clinical inspection is conducted 53 pregnant with placental insufficiency. As a result Doppler ultra-sonography researches of fetus and placenta complex are exposed multiplying a sistolo-diastolic index in uterine arteries, arteries of umbilical cord and middle cerebral artery of fetus. Plugging of tiocetam in therapy of placental insufficiency for pregnant is instrumental in normalization of indexes of Doppler ultrasonography that in a clinical plan combines the improved fetal condition and benefitial perinatal out-come.

136-143

Authors: O.I. Shevchenko, A.V. Storchak

It was performed an assessment of possible teratogenic and embryotoxic effects on female rats. It was calculated the quantity of luteal glands in rats ovaries, quantity of alive and newborn rats, also was evaluated the lethal effects before and after implantation, macroscopic assessment to determine visible malformation, investigation of internal organs and bony skeleton. The obtained data demonstrates the absence of embryolethal effect of D-glucosamine dose 90mg/kg. We had proved the absence of visible malformations in 20 days fetuses included skeleton malformations. So it was concluded that D-glucosamine had no teratogenic effects. These results was the only first step to D-glucosamine application in perinatology.

145-152

Authors: V.I. Medved, Т.V. Avramenko, О.Е. Danylkiv, V.Е. Islamova

All measures of preventive maintenance of extragenital pathology assotiated complications in pregnant women are offered for dividing on specific and not specific. The specific preventive maintenance is directed on prevention of complications of the basic disease which character is determined by the diagnosis. Not spe-cific preventive maintenance - complex of measures allowing to prevent a numberf subclinical conditions of pregnancy which are capable to aggravate current of extragenital pathology. The measures of not specific preventive maintenance are shown to all pregnant women and their character does not depend on the diagnosis. The basic ways of prevention of deficiencies, inherent in pregnancy, venous and infectious complications are described.

156-161

Authors: I.I. Stupak, I.V. Lakhno

The main processes of synthesis and secretion of prolactin as a basic lactation hormone are considered. The assumption about perspectives of bioelement exchange investigation for the optimization of preventive maintenance methods and treatment of hypohalactia is performed.