The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

5-9

Authors: S.V. Kalinichenko, Yu.L. Voljanski, E.M. Babich, O.B. Kolokolova, S.L. Krestezkay

The influence of the millimeter waves on the enzymatic activity of neiraminidase of different Coryne-bacteria was studied. It is established, that the effects of different diapasons of millimeter waves on the activity of this enzyme differs. The reliable stimulation of enzyme was remarked under influence of 61,0 HHz. The influence of 42.2 HHz diapasone, in contrast, inhibited the neiraminidase activity. The obtained data can be used in the extra high frequency therapy of bacteriocarriers of the toxigenic strains of Coryne-bacteria.

18-24

Authors: O.O. Olefirenko, I.V. Sleta, S.E. Galchenko

Processes of regeneration of the cirrhotic liver after cryodestruction and intraperitoneal injection of the extracts of liver and spleen from new-born piglets to rats have been studied. It has been shown that either applied methods acts on the reparation process in liver tissue. The studied methods can stop and reverse the cirrhotic process.

31-34

Authors: I.V. Sorokina, E.S. Protsenko

Morphological particularities of hepatocytes apoptosis in fetuses from mothers with diabetes type I were investigated on the basis of data of Kharkiv perinatal center and Sumy children pathologoanatomic depart-ment. As a result of performed study it was discovered that grade of fetal liver apoptosis depends on severity of mother’s diabetes I. Apoptosis index is reliably higher in liver of fetuses from mothers with I type diabetes comparing to fetuses from healthy mothers. Strong negative correlation has been established between grade of apoptosis and glycogen loss in hepatocytes’ cytoplasm. Therefore main task for endocrinologists and obstetricians must be the supply of stable compensation of carbohydrates exchange on all fetal development stages – from conception to birth.

42-47

Authors: Т.P. Yakimova, A.I. Tsivenco, E.S. Prosenco, M.S. Tomin

In the article authors presents the exspirience of making 24 hemorrhoidectomy with ultrasonic scalpel Ultraсision (Ethicon). Findings show reduction postoperative pain syndrom and minimal tissue damage in the patients that has hemorrhoidectomy with ultrasonic scalpel.

53-58

Authors: S.Yu. Bilyaevskaya, V.I. Cherniavsky, M.V. Smelianskaya, A.V. Martynov, S.D. Peremot, S.N. Davydova

The condition of immune system at patients with a stomach cancer (SC) was studied. System immu-nological infringements caused by bacterial-virus associations are revealed. In the greater measure it concerns group of patients with SC and presence НР and HHV in a tumour and in leukocytes. Such infringements are inherent in this group: considerably increased immune-rehulation index, a level of the circulation immune complex, authentic decrease of CD16, index of reaction of a blasttransformation of leucocytes.

63-66

Authors: G.N. Gerasimov

The analysis of autodermoplasty efficiency in treatment of prolonged not healing ulcers and wounds of the lower extremities at 52 patients with diabeteses mellitus using miscellaneous local treatment facilities and preparing to operations are presented in the article. On example of three groups of patients is proved higher efficiency of autodermoplasty (98.4±1.2%) when use Prostaglandin E1, a 5% -aminocapronic acid solution and gel of Solcoseril before the operation at this category of patients.

71-75

Authors: A.L. Kulik, O.I. Serikova

The study of anxiety and depression levels changes in comparison to QoLI and clinical indexes in patients with the pain form of chronic IHD with a presence or absence of depression on the stages of therapy is conducted. In all 103 patients were looked after in age 48,6±7,5. Patients, depending on the presence of depression, were parted on 2 groups. Initially in the group of patients with depression were marked increased level of anxiety, the QoLI decline, increase of mean values of stenocardia and heart failure FC, frequencies and the AH burden, on comparison with a group without depression. The standard IHD therapy improves the clinical being of patients in both groups, promoting QoLI, bringing the stenocardia and heart failure FC and diminishing the level of depression and anxiety. Thus at the patients IHD with concomitant depression as standard therapy results the change of depression, anxiety, QoLI levels and clinical status are expressed in less degree, not achieving the indexes got in the group of patients without depression. Persistent distinctions between groups testifies to the necessity of antidepressants addition to standard therapy.

77-83

Authors: Е.N. Pasko

Aim of the study of long-term inhalation glucocorticosteroids and bronchial spasmolytics therapy influence on the RF and HRV indexes in patients with bronchial asthma (BA) with an initially different forced expiratory volumes for 1 second for development of proposals on the improvement of therapy and BA control. 140 patients (58 men and 82 women) with I-IV degreeof BA were examined in ambulatory terms. Mean age – 48±2,5 years. Duration of disease – 9,3±8,1 years. RF was estimated by computer spirograph «SpiroSom» XAI, were taken into account: respiration rate frequency (RRF), forced expiratory volume for 1st, 2nd and 3rd seconds (FEV1,2,3), momentary volume speeds of the forced exhalation in the moment of 25, 50, 75% MEFL (MVS25,50,75). For the heart rate variability (HRV) analysis computer electrocardiograph «Cardiolab+» XAI was used; heart rate in 1 minute (HR); total power of spectrum (TP); spectrum power in area of high and low-frequencies (LF, HF) and relation of low and high frequencies spectrum regions powers (LF/HF) were estimated. Results showed that long-term BA therapy has positive influence on the RF indexes (FEV1,2,3, MVS25,50,75) and HRV(ТР, LF,HF, LF\HF) in all patients groups. The increase of the RF indexes depends on the initial FEV1 value and is most marked in the group of patients with FEV 1 values 80-60%. Interrelation between the FEV1 and HRV TP value in patients with BA confirms meaningfulness of regulatory mechanisms in breathing for state of health of patients and results of medical treatment.

88-92

Authors: E.A. Romanova, T.A. Sidorenko, N.I. Igumnova, L.G. Gogadze

Morphologic and cytogenetic variations of hemopoesis of rats by influence antenatal radiation was studied. Cellular composition of bone marrow of antenataly irradiated animals testify about expressed disbalance of the production, maturation and differentiation of hemopoietic cells in the all hemopoetic sprouts. It was found the increase of cells with chromosomal aberrations among the irradiated posteritys myelocariocytes.

96-100

Authors: E.D. Khvorostov, Yu.B. Zakharchenko, A.S, Shapovalov

The analysis of 4 patients with chronic calculous cholecystitis in combination with gallstone-intestinal bile fistula treatment was carried out. 3 patients had gallstone-duodenal bile fistula, 1 patient had gallstone-transverse-colon bile fistula. The diagnostics of gallstone-intestinal bile fistula in patients with chronic calculous cholecystitis is difficult and required wide investigation using expensive invasive methods. Fistula was diagnostic in the time laparoscopic cholecystectomy. The current of operative intervention was changed. Technical methods were used for the fistula removal. Gallstone-intestinal bile fistula may be removed in the time laparoscopic cholecystectomy using minilaparotomy in right subcostal area for extraction of gallbladder and suture intestinal wall without considerable trauma increase due to operation.

105-117

Authors: V.I. Padalko, T.V. Sevastyanova

In the present review modern representations about cytochrome P-450 system and roles of its major multiple forms in an organism are generalized. Drugs induction or inhibition of this system are discussed. Important for clinic interactions of drugs with P-450 enzymes are given and practical ways of prevention or minimization of negative consequences of interactions of medical products are discussed.